Vitali Sintchenko Centre for Infectious Diseases and Microbiology-Public Health Westmead Hospital Biography Publications Institution JoVE Articles Vitali Sintchenko has not added a biography. If you are Vitali Sintchenko and would like to personalize this page please email our Author Liaison for assistance. Publications Genome Sequencing Links Persistent Outbreak of Legionellosis in Sydney to an Emerging Clone of Legionella Pneumophila ST211 Applied and Environmental Microbiology. Dec, 2017 | Pubmed ID: 29247056 Comparative Genomics of Australian and International Isolates of Salmonella Typhimurium: Correlation of Core Genome Evolution with CRISPR and Prophage Profiles Scientific Reports. Aug, 2017 | Pubmed ID: 28851865 Drug Resistance and Mycobacterium Tuberculosis Strain Diversity in TB/HIV Co-infected Patients in Ho Chi Minh City, Vietnam Journal of Global Antimicrobial Resistance. Sep, 2017 | Pubmed ID: 28743648 Francisella Tularensis Ssp. Holarctica in Ringtail Possums, Australia Emerging Infectious Diseases. 07, 2017 | Pubmed ID: 28628459 Genomic Heterogeneity of Salmonella Enterica Serovar Typhimurium Bacteriuria from Chronic Infection Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. Jul, 2017 | Pubmed ID: 28279807 Characterisation of the Bordetella Pertussis Secretome Under Different Media Journal of Proteomics. Mar, 2017 | Pubmed ID: 28242451 Evolution of Variable Number Tandem Repeats and Its Relationship with Genomic Diversity in Salmonella Typhimurium Frontiers in Microbiology. 2016 | Pubmed ID: 28082952 Transmission of Multi-drug Resistant Tuberculosis in Mongolia is Driven by Beijing Strains of Mycobacterium Tuberculosis Resistant to All First-line Drugs Tuberculosis (Edinburgh, Scotland). Dec, 2016 | Pubmed ID: 27865397 16S-23S Internal Transcribed Spacer Region PCR and Sequencer-Based Capillary Gel Electrophoresis Has Potential As an Alternative to High Performance Liquid Chromatography for Identification of Slowly Growing Nontuberculous Mycobacteria PloS One. 2016 | Pubmed ID: 27749897 Whole Genome Sequencing Demonstrates Limited Transmission Within Identified Mycobacterium Tuberculosis Clusters in New South Wales, Australia PloS One. 2016 | Pubmed ID: 27737005 SnpFilt: A Pipeline for Reference-free Assembly-based Identification of SNPs in Bacterial Genomes Computational Biology and Chemistry. 12, 2016 | Pubmed ID: 27647159 Whole Genome Sequencing of Salmonella Typhimurium Illuminates Distinct Outbreaks Caused by an Endemic Multi-locus Variable Number Tandem Repeat Analysis Type in Australia, 2014 BMC Microbiology. Sep, 2016 | Pubmed ID: 27629541 Better Colonisation of Newly Emerged Bordetella Pertussis in the Co-infection Mouse Model Study Vaccine. 07, 2016 | Pubmed ID: 27346304 Nontoxic Metal-Cyclam Complexes, a New Class of Compounds with Potency Against Drug-Resistant Mycobacterium Tuberculosis Journal of Medicinal Chemistry. Jun, 2016 | Pubmed ID: 27214150 DfrA ThyA Double Deletion in Para-Aminosalicylic Acid-Resistant Mycobacterium Tuberculosis Beijing Strains Antimicrobial Agents and Chemotherapy. Jun, 2016 | Pubmed ID: 27021327 Concordance of Four Commercial Enzyme Immunoassay and Three Immunoblot Formats for the Detection of Lyme Borreliosis Antibodies in Human Serum: the Two-tier Approach Remains Pathology. Apr, 2016 | Pubmed ID: 27020501 Identifying Likely Transmission Pathways Within a 10-Year Community Outbreak of Tuberculosis by High-Depth Whole Genome Sequencing PloS One. 2016 | Pubmed ID: 26938641 Genomic Dissection of Australian Bordetella Pertussis Isolates from the 2008-2012 Epidemic The Journal of Infection. Apr, 2016 | Pubmed ID: 26826518 Genotype Heterogeneity of Mycobacterium Tuberculosis Within Geospatial Hotspots Suggests Foci of Imported Infection in Sydney, Australia Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. 06, 2016 | Pubmed ID: 26187743 Antibiotic Susceptibility of Diverse Mycobacterium Abscessus Complex Strains in New South Wales, Australia Pathology. Dec, 2015 | Pubmed ID: 26517625 Pertactin Negative Bordetella Pertussis Demonstrates Higher Fitness Under Vaccine Selection Pressure in a Mixed Infection Model Vaccine. Nov, 2015 | Pubmed ID: 26432908 It Is Not All About Single Nucleotide Polymorphisms: Comparison of Mobile Genetic Elements and Deletions in Listeria Monocytogenes Genomes Links Cases of Hospital-Acquired Listeriosis to the Environmental Source Journal of Clinical Microbiology. Nov, 2015 | Pubmed ID: 26311854 Genomic Variability of Serial Human Isolates of Salmonella Enterica Serovar Typhimurium Associated with Prolonged Carriage Journal of Clinical Microbiology. Nov, 2015 | Pubmed ID: 26311853 Epidemiology of Peripheral Lymph Node Tuberculosis and Genotyping of M. Tuberculosis Strains: A Case-Control Study PloS One. 2015 | Pubmed ID: 26177546 Editorial: Laboratory Preparedness for Ebolavirus Disease Pathology. Aug, 2015 | Pubmed ID: 26126052 Genomic Epidemiology of Clostridium Botulinum Isolates from Temporally Related Cases of Infant Botulism in New South Wales, Australia Journal of Clinical Microbiology. Sep, 2015 | Pubmed ID: 26109442 Defining the Core Genome of Salmonella Enterica Serovar Typhimurium for Genomic Surveillance and Epidemiological Typing Journal of Clinical Microbiology. Aug, 2015 | Pubmed ID: 26019201 Genome Sequencing Reveals Novel Deletions Associated with Secondary Resistance to Pyrazinamide in MDR Mycobacterium Tuberculosis The Journal of Antimicrobial Chemotherapy. Sep, 2015 | Pubmed ID: 25977398 The Role of Pathogen Genomics in Assessing Disease Transmission BMJ (Clinical Research Ed.). May, 2015 | Pubmed ID: 25964672 Intercontinental Dissemination of Azithromycin-resistant Shigellosis Through Sexual Transmission: a Cross-sectional Study The Lancet. Infectious Diseases. Aug, 2015 | Pubmed ID: 25936611 Proficiency Testing for Bacterial Whole Genome Sequencing: an End-user Survey of Current Capabilities, Requirements and Priorities BMC Infectious Diseases. Apr, 2015 | Pubmed ID: 25887164 Delineating Community Outbreaks of Salmonella Enterica Serovar Typhimurium by Use of Whole-genome Sequencing: Insights into Genomic Variability Within an Outbreak Journal of Clinical Microbiology. Apr, 2015 | Pubmed ID: 25609719 Added Value of Whole-genome Sequencing for Management of Highly Drug-resistant TB The Journal of Antimicrobial Chemotherapy. Apr, 2015 | Pubmed ID: 25492392 Investigating Genome Reduction of Bordetella Pertussis Using a Multiplex PCR-based Reverse Line Blot Assay (mPCR/RLB) BMC Research Notes. Oct, 2014 | Pubmed ID: 25319278 Clinical Microbiology Informatics Clinical Microbiology Reviews. Oct, 2014 | Pubmed ID: 25278581 Temporal Dynamics of Mycobacterium Tuberculosis Genotypes in New South Wales, Australia BMC Infectious Diseases. Aug, 2014 | Pubmed ID: 25149181 Fluoroquinolone Resistance in Non-multidrug-resistant Tuberculosis-a Surveillance Study in New South Wales, Australia, and a Review of Global Resistance Rates International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases. Sep, 2014 | Pubmed ID: 25086437 Use of the 5' Untranslated Region and VP1 Region to Examine the Molecular Diversity in Enterovirus B Species Journal of Medical Microbiology. Oct, 2014 | Pubmed ID: 25038138 Improved Identification of Rapidly Growing Mycobacteria by a 16S-23S Internal Transcribed Spacer Region PCR and Capillary Gel Electrophoresis PloS One. 2014 | Pubmed ID: 25013955 Pathogen Genome Bioinformatics Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 24870136 Rapid Increase in Pertactin-deficient Bordetella Pertussis Isolates, Australia Emerging Infectious Diseases. Apr, 2014 | Pubmed ID: 24655754 Potent Antimycobacterial Activity of the Pyridoxal Isonicotinoyl Hydrazone Analog 2-pyridylcarboxaldehyde Isonicotinoyl Hydrazone: a Lipophilic Transport Vehicle for Isonicotinic Acid Hydrazide Molecular Pharmacology. Feb, 2014 | Pubmed ID: 24243647 Effectiveness of Hospital-wide Methicillin-resistant Staphylococcus Aureus (MRSA) Infection Control Policies Differs by Ward Specialty PloS One. 2013 | Pubmed ID: 24340085 The Use of Mycobacterial Interspersed Repetitive Unit Typing and Whole Genome Sequencing to Inform Tuberculosis Prevention and Control Activities New South Wales Public Health Bulletin. Jul, 2013 | Pubmed ID: 23849021 Software for Selecting the Most Informative Sets of Genomic Loci for Multi-target Microbial Typing BMC Bioinformatics. May, 2013 | Pubmed ID: 23635100 Quantitative Estimation of the Stability of Methicillin-resistant Staphylococcus Aureus Strain-typing Systems by Use of Kaplan-Meier Survival Analysis Journal of Clinical Microbiology. Jan, 2013 | Pubmed ID: 23100339 Assignment of RecA Reference Sequence Types for Enhanced Identification of the Burkholderia Cepacia Complex Pathology. Jun, 2012 | Pubmed ID: 28193343 Francisella Tularensis Subspecies Holarctica, Tasmania, Australia, 2011 Emerging Infectious Diseases. Sep, 2012 | Pubmed ID: 22931809 Prospective Genotyping of Hospital-acquired Methicillin-resistant Staphylococcus Aureus Isolates by Use of a Novel, Highly Discriminatory Binary Typing System Journal of Clinical Microbiology. Nov, 2012 | Pubmed ID: 22895043 Linear Normalised Hash Function for Clustering Gene Sequences and Identifying Reference Sequences from Multiple Sequence Alignments Microbial Informatics and Experimentation. Jan, 2012 | Pubmed ID: 22587938 Impact of a Web-based Personally Controlled Health Management System on Influenza Vaccination and Health Services Utilization Rates: a Randomized Controlled Trial Journal of the American Medical Informatics Association : JAMIA. Sep-Oct, 2012 | Pubmed ID: 22582203 Protocol for a Randomised Controlled Trial Examining the Impact of a Web-based Personally Controlled Health Management System on the Uptake of Influenza Vaccination Rates BMC Health Services Research. Apr, 2012 | Pubmed ID: 22462549 Improving Resolution of Public Health Surveillance for Human Salmonella Enterica Serovar Typhimurium Infection: 3 Years of Prospective Multiple-locus Variable-number Tandem-repeat Analysis (MLVA) BMC Infectious Diseases. Mar, 2012 | Pubmed ID: 22462487 Selection and Emergence of Pertussis Toxin Promoter PtxP3 Allele in the Evolution of Bordetella Pertussis Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. Jan, 2012 | Pubmed ID: 22293463 Genetic Relationships of Phage Types and Single Nucleotide Polymorphism Typing of Salmonella Enterica Serovar Typhimurium Journal of Clinical Microbiology. Jan, 2012 | Pubmed ID: 22205813 Translational Web Robots for Pathogen Genome Analysis Microbial Informatics and Experimentation. Oct, 2011 | Pubmed ID: 22587672 Defining Reference Sequences for Nocardia Species by Similarity and Clustering Analyses of 16S RRNA Gene Sequence Data PloS One. 2011 | Pubmed ID: 21687706 Computational Bacterial Genome-wide Analysis of Phylogenetic Profiles Reveals Potential Virulence Genes of Streptococcus Agalactiae PloS One. 2011 | Pubmed ID: 21483735 Improved Identification of Gordonia, Rhodococcus and Tsukamurella Species by 5'-end 16S RRNA Gene Sequencing Pathology. Jan, 2011 | Pubmed ID: 21240067 Editor's Choice: Implications of Isoniazid Resistance in Mycobacterium Bovis Bacillus Calmette-Guérin Used for Immunotherapy in Bladder Cancer Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Jan, 2011 | Pubmed ID: 21148524 Insight into Evolution of Bordetella Pertussis from Comparative Genomic Analysis: Evidence of Vaccine-driven Selection Molecular Biology and Evolution. Jan, 2011 | Pubmed ID: 20833694 Bug Breakfast in the Bulletin: Biosecurity and Infectious Diseases New South Wales Public Health Bulletin. May-Jun, 2010 | Pubmed ID: 21604605 SecA1 Gene Sequence Polymorphisms for Species Identification of Nocardia Species and Recognition of Intraspecies Genetic Diversity Journal of Clinical Microbiology. Nov, 2010 | Pubmed ID: 20810768 Unexpected Diversity of Staphylococcal Cassette Chromosome Mec Type IV in Methicillin-resistant Staphylococcus Aureus Strains Journal of Clinical Microbiology. Oct, 2010 | Pubmed ID: 20686095 Rapid Identification of Methicillin-resistant Staphylococcus Aureus Transmission in Hospitals by Use of Phage-derived Open Reading Frame Typing Enhanced by Multiplex PCR and Reverse Line Blot Assay Journal of Clinical Microbiology. Aug, 2010 | Pubmed ID: 20519463 Three-year Longitudinal Study of Genotypes of Mycobacterium Tuberculosis in a Low Prevalence Population Pathology. Apr, 2010 | Pubmed ID: 20350221 A PubMed-wide Associational Study of Infectious Diseases PloS One. 2010 | Pubmed ID: 20224767 Bordetella Pertussis Clones Identified by Multilocus Variable-number Tandem-repeat Analysis Emerging Infectious Diseases. Feb, 2010 | Pubmed ID: 20113564 Reverse Line Blot Hybridization and DNA Sequencing Studies of the 16S-23S RRNA Gene Intergenic Spacer Regions of Five Emerging Pathogenic Nocardia Species Journal of Medical Microbiology. May, 2010 | Pubmed ID: 20110385 Identification of Pathogenic Nocardia Species by Reverse Line Blot Hybridization Targeting the 16S RRNA and 16S-23S RRNA Gene Spacer Regions Journal of Clinical Microbiology. Feb, 2010 | Pubmed ID: 19955277 Commonly Used Molecular Epidemiology Markers of Streptococcus Agalactiae Do Not Appear to Predict Virulence Pathology. 2009 | Pubmed ID: 19900108 Influenza Outbreak During Sydney World Youth Day 2008: the Utility of Laboratory Testing and Case Definitions on Mass Gathering Outbreak Containment PloS One. 2009 | Pubmed ID: 19727401 Assignment of Reference 5'-end 16S RDNA Sequences and Species-Specific Sequence Polymorphisms Improves Species Identification of Nocardia The Open Microbiology Journal. 2009 | Pubmed ID: 19639036 Rolling Circle Amplification and Multiplex Allele-specific PCR for Rapid Detection of KatG and InhA Gene Mutations in Mycobacterium Tuberculosis International Journal of Medical Microbiology : IJMM. Dec, 2009 | Pubmed ID: 19604720 A New Multiplex PCR-based Reverse Line-blot Hybridization (mPCR/RLB) Assay for Rapid Staphylococcal Cassette Chromosome Mec (SCCmec) Typing Journal of Medical Microbiology. Aug, 2009 | Pubmed ID: 19528184 Identification of Non-tuberculous Mycobacteria: Utility of the GenoType Mycobacterium CM/AS Assay Compared with HPLC and 16S RRNA Gene Sequencing Journal of Medical Microbiology. Jul, 2009 | Pubmed ID: 19502366 Laboratory-guided Detection of Disease Outbreaks: Three Generations of Surveillance Systems Archives of Pathology & Laboratory Medicine. Jun, 2009 | Pubmed ID: 19492884 Rapid and Accurate Typing of Bordetella Pertussis Targeting Genes Encoding Acellular Vaccine Antigens Using Real Time PCR and High Resolution Melt Analysis Journal of Microbiological Methods. Jun, 2009 | Pubmed ID: 19341769 In Silico Prioritisation of Candidate Genes for Prokaryotic Gene Function Discovery: an Application of Phylogenetic Profiles BMC Bioinformatics. 2009 | Pubmed ID: 19292914 Towards Bioinformatics Assisted Infectious Disease Control BMC Bioinformatics. 2009 | Pubmed ID: 19208185 Biosurveillance of Emerging Biothreats Using Scalable Genotype Clustering Journal of Biomedical Informatics. Feb, 2009 | Pubmed ID: 18723122 The Re-emergence of Pertussis: Implications for Diagnosis and Surveillance New South Wales Public Health Bulletin. Jul-Aug, 2008 | Pubmed ID: 19007547 Decision Support Systems for Antibiotic Prescribing Current Opinion in Infectious Diseases. Dec, 2008 | Pubmed ID: 18988320 Genome-wide Analysis of Single Nucleotide Polymorphisms in Bordetella Pertussis Using Comparative Genomic Sequencing Research in Microbiology. Nov-Dec, 2008 | Pubmed ID: 18790049 Developing Decision Support Systems in Clinical Bioinformatics Methods in Molecular Medicine. 2008 | Pubmed ID: 18453098 Are Clinicians' Information Needs and Decision Support Affected by Different Models of Care? Experimental Study Studies in Health Technology and Informatics. 2007 | Pubmed ID: 17911845 Is Bordetella Pertussis Susceptibility to Erythromycin Changing? MIC Trends Among Australian Isolates 1971-2006 The Journal of Antimicrobial Chemotherapy. Nov, 2007 | Pubmed ID: 17827145 Comparison of Single- and Multilocus Sequence Typing and Toxin Gene Profiling for Characterization of Methicillin-resistant Staphylococcus Aureus Journal of Clinical Microbiology. Oct, 2007 | Pubmed ID: 17715374 Are We Measuring the Right End-points? Variables That Affect the Impact of Computerised Decision Support on Patient Outcomes: a Systematic Review Medical Informatics and the Internet in Medicine. Sep, 2007 | Pubmed ID: 17701828 Point-of-care Testing for Community-acquired Pneumonia: Do We Have All the Answers? The Medical Journal of Australia. Jul, 2007 | Pubmed ID: 17605702 Pathogen Profiling for Disease Management and Surveillance Nature Reviews. Microbiology. Jun, 2007 | Pubmed ID: 17487146 An Outbreak of Pulmonary Tuberculosis in Young Australians The Medical Journal of Australia. Mar, 2007 | Pubmed ID: 17391086 Utility of Genotyping of Mycobacterium Tuberculosis in the Contact Investigation: a Decision Analysis Tuberculosis (Edinburgh, Scotland). May, 2007 | Pubmed ID: 17161653 Decision Complexity Affects the Extent and Type of Decision Support Use AMIA ... Annual Symposium Proceedings / AMIA Symposium. AMIA Symposium. 2006 | Pubmed ID: 17238436 Genotyping of Mycobacterium Tuberculosis in New South Wales: Results from 18 Months of a Statewide Trial New South Wales Public Health Bulletin. May-Jun, 2006 | Pubmed ID: 17036086 A Case of Urinary Tuberculosis Due to Mycobacterium Bovis Subspecies Caprae Pathology. Aug, 2006 | Pubmed ID: 16916737 Screening for Antibiotic Resistant Gram-negative Bacteria The Lancet Infectious Diseases. Jun, 2006 | Pubmed ID: 16728313 Handheld Computer-based Decision Support Reduces Patient Length of Stay and Antibiotic Prescribing in Critical Care Journal of the American Medical Informatics Association : JAMIA. Jul-Aug, 2005 | Pubmed ID: 15802478 Comparative Impact of Guidelines, Clinical Data, and Decision Support on Prescribing Decisions: an Interactive Web Experiment with Simulated Cases Journal of the American Medical Informatics Association : JAMIA. Jan-Feb, 2004 | Pubmed ID: 14527970 Which Clinical Decisions Benefit from Automation? A Task Complexity Approach International Journal of Medical Informatics. Jul, 2003 | Pubmed ID: 12909183 Which Clinical Decisions Benefit from Automation? A Task Complexity Approach Studies in Health Technology and Informatics. 2002 | Pubmed ID: 15460772 Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance Chayanika Biswas*1, Sharon C-A. Chen*1,2,3, Catriona Halliday1,2, Elena Martinez1, Rebecca J. Rockett1, Qinning Wang1, Verlaine J. Timms1, Rajat Dhakal1, Rosemarie Sadsad1, Karina J. Kennedy4, Geoffrey Playford4,5, Deborah J. Marriott6, Monica A. Slavin7, Tania C. Sorrell1,3, Vitali Sintchenko1,2,3 1Centre for Infectious Diseases and Microbiology-Public Health, Westmead Hospital, 2Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, 3Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, 4Department of Microbiology and Infectious Diseases, Canberra Hospital and Health Services, Australian National University Medical School, 5Infection Management Services, Australian National University Medical School, 6Department of Microbiology and Infectious Diseases, St. Vincent's Hospital, 7Department of Infectious Diseases, Peter MacCallum Cancer Centre JoVE 56714 Medicina Multiplex PCR and Reverse Line Blot Hybridization Assay (mPCR/RLB) Matthew V. N. O'Sullivan1, Fei Zhou1, Vitali Sintchenko1, Fanrong Kong1, Gwendolyn L. Gilbert1 1Centre for Infectious Diseases and Microbiology, University of Sydney JoVE 2781 Biologia
Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance Chayanika Biswas*1, Sharon C-A. Chen*1,2,3, Catriona Halliday1,2, Elena Martinez1, Rebecca J. Rockett1, Qinning Wang1, Verlaine J. Timms1, Rajat Dhakal1, Rosemarie Sadsad1, Karina J. Kennedy4, Geoffrey Playford4,5, Deborah J. Marriott6, Monica A. Slavin7, Tania C. Sorrell1,3, Vitali Sintchenko1,2,3 1Centre for Infectious Diseases and Microbiology-Public Health, Westmead Hospital, 2Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, 3Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, 4Department of Microbiology and Infectious Diseases, Canberra Hospital and Health Services, Australian National University Medical School, 5Infection Management Services, Australian National University Medical School, 6Department of Microbiology and Infectious Diseases, St. Vincent's Hospital, 7Department of Infectious Diseases, Peter MacCallum Cancer Centre JoVE 56714 Medicina
Multiplex PCR and Reverse Line Blot Hybridization Assay (mPCR/RLB) Matthew V. N. O'Sullivan1, Fei Zhou1, Vitali Sintchenko1, Fanrong Kong1, Gwendolyn L. Gilbert1 1Centre for Infectious Diseases and Microbiology, University of Sydney JoVE 2781 Biologia