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Immunohistochemical Staining of B7-H1 (PD-L1) on Paraffin-embedded Slides of Pancreatic Adenocarcinoma Tissue
 

Immunohistochemical Staining of B7-H1 (PD-L1) on Paraffin-embedded Slides of Pancreatic Adenocarcinoma Tissue

Article DOI: 10.3791/4059-v • 10:11 min • January 3rd, 2013
January 3rd, 2013 •
1,2, 1,2, 1,2,3, 1, 1,2,4, 3,5, 6, 1,2,5,7,8, 1,2,5,8, 1,2,4,5,7
1The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 2Department of Oncology, The Johns Hopkins University School of Medicine, 3Department of Dermatology, The Johns Hopkins University School of Medicine, 4Department of Surgery, Johns Hopkins University School of Medicine, 5The Sol Goldman Pancreatic Cancer Center, The Johns Hopkins University School of Medicine, 6Yale Cancer Center, Yale School of Medicine, 7The Skip Viragh Center for Pancreatic Cancer, The Johns Hopkins University School of Medicine, 8Department of Pathology, The Johns Hopkins University School of Medicine

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B7-H1 (PD-L1) and its binding to PD-1 provide a major tumor-induced immunosuppressive signal in the tumor’s microenvironment. An immunohistochemical staining technique to characterize the expression and localization of B7-H1 in pancreatic adenocarcinoma is described here.

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Immunohistochemical Staining B7-H1 PD-L1 Paraffin-embedded Slides Pancreatic Adenocarcinoma Tissue Immune-regulatory Cell-surface Proteins Negative Regulation Cell-mediated Immune Responses Receptor Programmed Death-1 Overexpression Tumor Cells Human Cancers Prognostic Marker Anti-tumor T-cell Immunity Therapeutic Target Blockade Antibodies Clinical Trials Solid Tumors Expression And Localization Patient Response Treatment
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