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Immunology and Infection

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JoVE Journal Immunology and Infection
The Synergistic Effect of Visible Light and Gentamycin on Pseudomona aeruginosa Microorganisms
 

The Synergistic Effect of Visible Light and Gentamycin on Pseudomona aeruginosa Microorganisms

Article DOI: 10.3791/4370-v • 05:57 min • July 2nd, 2013
July 2nd, 2013 •
1, 2, 3, 3, 4, 4
1Department of Physics, Bar-Ilan University, 2The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, 3Department of Chemistry, Bar-Ilan University, 4Faculty of Engineering, Bar-Ilan University

Capitoli

Riepilogo
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We show that a developed biomedical device involving continuous or pulsed visible laser based treatment that is combined with antibiotic treatment (gentamycin), results in a statistically significant synergistic effect leading to a reduction in the viability of P. aeruginosa PAO1, by 8 log's compared to antibiotic treatment alone.

Tags

Synergistic Effect Visible Light Gentamycin Pseudomonas Aeruginosa Bactericidal Effect Blue Light Spectrum Phototoxic Effect Reactive Oxygen Species (ROS) Endogenous Bacterial Photosensitizers Biocidal Effect Red Light Near Infra Red Light Green Light High Power Green Light Continuous Wave (CW) Light Pulsed Q-switched (Q-S) Light Antibiotic Treatment Gentamycin Bacteria Viability Nosocomial Opportunistic Pathogen AcrB/Mex-type RND Multidrug Efflux Systems Gram-negative Bacteria
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