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Immunology and Infection

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JoVE Journal Immunology and Infection
New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals
 

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals

Article DOI: 10.3791/50244-v • 09:27 min • May 30th, 2013
May 30th, 2013 •
1, 1, 1,2
1Ragon Institute of MGH, MIT, and Harvard, 2Division of Infectious Diseases, Massachusetts General Hospital

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CD4+ Regulatory T cells are potent immune-modulators and serve important functions in immune homeostasis. The paucity of these cells in peripheral blood makes functional studies challenging, specifically in the context of HIV-1-infection. We here describe a method to isolate and expand functional CD4+ Tregs from peripheral blood from HIV-1-infected individuals.

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Keywords: HIV-1 Regulatory T Cells Tregs CD4+ T Cells Immune Modulation Immunopathogenesis Expansion In Vitro Flow Cytometry FOXP3 CTLA4 HELIOS Suppression
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