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Bioengineering

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JoVE Journal Bioengineering
Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
 

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Article DOI: 10.3791/50533-v • 12:19 min • July 1st, 2013
July 1st, 2013 •
1, 1,2, 1, 1,2, 1,2, 1,3, 1,3, 1,3
1Biomatériaux et Bioingénieriee, INSERM, 2Service Oto-Rhino-Laryngologie, Hôpitaux Universitaires de Strasbourg, 3Faculté de Chirurgie Dentaire, Université de Strasbourg

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In this video, we will demonstrate modification techniques for porous metallic implants to improve their functionality and to control cell migration. Techniques include development of pore gradients to control cell movement in 3D and production of basement membrane mimics to control cell movement in 2-D. Also, a HPLC-based method for monitoring implant integration in-vivo via analysis of blood proteins is described.

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Keywords: Metallic Implants Titanium Porous Structure Pore Gradients Polyelectrolytes Tissue Integration Hydrophobicity Hydrophilicity PLLA Collagen Alginate Cell Migration Trachea Regeneration CGA Blood Proteins In Vivo Monitoring Histology
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