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Journal / Medicine / Microarray-based Identification of Individual…
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Medicine

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JoVE Journal Medicine
Microarray-based Identification of Individual HERV Loci Expression
 

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Article DOI: 10.3791/50713-v • 13:19 min • November 2nd, 2013
November 2nd, 2013 •
1,2, 1,2, 1,3,4, 1,2, 5, 1,4,6, 1,4,7, 1,2
1Joint Unit Hospices de Lyon-bioMérieux, 2Medical Diagnostic Discovery Department, BioMérieux, 3Department of Pathology and Cytology, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 4Medical Faculty, Lyon 1 University, 5Data and Knowledge Laboratory, BioMérieux, 6Department of Biochemistry and Molecular Biology, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 7Department of Urology, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon

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Human endogenous retroviruses (HERV), which occupy 8% of the human genome, retain scarce coding capacities but a hundred thousand long terminal repeats (LTRs). A custom Affymetrix microarray was designed to identify individual HERV locus expression and was used on prostate cancer tissues as a proof of concept for future clinical studies.

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Keywords: Microarray HERV Prostate Cancer Biomarker PSA Noncoding RNA Transcriptional Regulation Genome
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