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Immunology and Infection

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JoVE Journal Immunology and Infection
Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
 

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Article DOI: 10.3791/51174-v • 11:32 min • February 23rd, 2014
February 23rd, 2014 •
1, 1, 1, 1, 1, 1, 1
1Department Genetics of Microorganisms, Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald

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Streptococcus pneumoniae is the leading pathogen causing severe community-acquired pneumonia and responsible for over 2 million deaths worldwide. The impact of bacterial factors implicated in fitness or virulence can be monitored in real-time in an acute mouse pneumonia or bacteremia model using bioluminescent bacteria.

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Keywords: Pneumonia Pneumococcus Streptococcus Pneumoniae Virulence Factors Bioluminescence Mouse Model Acute Infection Real-time Monitoring Dissemination Bacteremia
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