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JoVE Journal Medicine
DNBS/TNBS Colitis Models
 

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Article DOI: 10.3791/51297-v • 09:04 min • February 27th, 2014
February 27th, 2014 •
*1, *1, 1, 1, 1, 1, 1
1Division of Gastroenterology, BC Children's Hospital
* These authors contributed equally

Capitoli

Riepilogo
Automatic Translation

DNBS/TNBS induced colitis offers an alternative and inexpensive method to study the pathobiology of inflammatory bowel disease. The protocol discussed in this paper outlines the successful application of DNBS to induce colitis in mice and rats and allows one to thoroughly study host-mediated intestinal responses.

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Keywords: DNBS TNBS Colitis Inflammatory Bowel Disease Dietary Fat N-3 Fatty Acids N-6 Fatty Acids Safflower Oil Canola Oil Fish Oil Weight Loss Mucosal Inflammation Myeloperoxidase
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