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Rat Heterotopic Abdominal Heart/Single-lung Transplantation in a Volume-loaded Configuration
 

Rat Heterotopic Abdominal Heart/Single-lung Transplantation in a Volume-loaded Configuration

Article DOI: 10.3791/52418-v • 06:16 min • May 29th, 2015
May 29th, 2015 •
1, 3, 2
1Cardiovascular Surgery, UBC James Hogg Research Center, St. Paul's Hospital, 2Respiratory and Critical Care Medicine, UBC James Hogg Research Center, St. Paul's Hospital, 3UBC James Hogg Research Center, St. Paul's Hospital

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We describe a novel technique for heterotopic abdominal heart-lung transplantation (HAHLT) in rats. The transplant configuration results in a partially loaded graft circulation, allowing direct functional assessment. This model may be employed for acute or chronic studies of function and immunologic status of the transplanted graft.

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Rat Heterotopic Abdominal Heart-lung Transplantation HAHLT Transplant Graft Inferior Vena Cava Ascending Aorta Lung Lobes Volume-loading Configuration Cardiac Function Pressure-volume Conductance Catheters Surgical Techniques Myocardial Protection Strategy Graft Function Immunologic Status Ventricular Loading Conditions Conducting Airways
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