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A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases
 

A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases

Article DOI: 10.3791/52495-v • 09:31 min • February 21st, 2015
February 21st, 2015 •
1, 1, 1,2
1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, 2Department of Neuroscience, Icahn School of Medicine at Mount Sinai

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This protocol describes how neural progenitor cells can be differentiated from human induced pluripotent stem cells, in order to yield a robust and replicative neural cell population, which may be used to identify the developmental pathways contributing to disease pathogenesis in many neurological disorders.

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Keywords: HiPSC Neural Progenitor Cells Neurological Diseases Post-mortem Studies Disease Initiation Patient-derived Differentiation Neurospheres Genetic Screening Cellular Phenotypes
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