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A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
 

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Article DOI: 10.3791/54136-v • 09:37 min • July 14th, 2016
July 14th, 2016 •
*1, *1, *1, 2, 2, 1,2
1Department of Environmental Health Sciences, Yale University School of Medicine, 2Department of Ophthalmology, Yale University School of Medicine
* These authors contributed equally

Capitoli

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A reverse-genetics approach to understanding gene families associated with human disease is presented, using mouse as a model system, and the subsequent mouse phenotyping schedule is described. Because mice defective in a gene of interest, HtrA2, manifested Parkinsonian symptoms, the phenotyping regimen is focused on identifying neurological defects.

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Phenotyping Regimen Genetically Modified Mice Human Diseases Of Aging Behavioral Phenotypes Tissue Structure And Function Hind Limb Test Muscle Strength Weakness Fatigue Acclimation Cotton Balls Vertical Position Weight Measurement Pull Attempts Latency To Fall
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