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Journal / Immunology and Infection / Normal and Malignant Muscle Cell Transplantation…
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Immunology and Infection

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JoVE Journal Immunology and Infection
Normal and Malignant Muscle Cell Transplantation into Immune Compromised Adult Zebrafish
 

Normal and Malignant Muscle Cell Transplantation into Immune Compromised Adult Zebrafish

Article DOI: 10.3791/52597-v • 09:39 min • December 26th, 2014
December 26th, 2014 •
*1,2,3, *1,2, 1,2, 1,2
1Molecular Pathology, Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, 2Harvard Stem Cell Institute, 3GABBA - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto
* These authors contributed equally

Capitoli

Riepilogo
Automatic Translation

Here, we present a protocol for cell transplantation of zebrafish skeletal muscle and embryonal rhabdomyosarcoma (ERMS) into adult immune compromised rag2E450fs homozygous mutant zebrafish. This protocol allows for the efficient analysis of regeneration and malignant transformation of muscle cells.

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Keywords: Zebrafish Cell Transplantation Skeletal Muscle Rhabdomyosarcoma Rag2 Mutant Immune Compromised Engraftment Regeneration Cancer
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