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Minimally Invasive Transverse Aortic Constriction in Mice
 

Minimally Invasive Transverse Aortic Constriction in Mice

Article DOI: 10.3791/55293-v • 07:40 min • March 14th, 2017
March 14th, 2017 •
1, 2, 3, 1
1School of Biological Sciences, The University of Hong Kong, 2College of Arts and Science, New York University, 3Department of Health Technology and Informatics, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University

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Minimally invasive transverse aortic constriction (MTAC) conserves the essentials of regular transverse aortic constriction (TAC) while eliminating the use of a ventilator with tracheal intubation. It proves to be a highly desirable method for high-throughput studies on left ventricular overload, particularly in translational studies.

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Keywords: Minimally Invasive Transverse Aortic Constriction Mice Left Ventricular Hypertrophy Myocardial Remodeling Cardiac Hypertrophy Apoptosis Fibrosis Left Ventricular Pressure Overload Surgical Procedure Transverse Aortic Arch 30-gauge Needles 27-gauge Needle 0.4 Millimeter Spacer Sedation Heating Pad Midline Incision Blunt Dissection Thyroid Gland Sternum Thymus Lobes Transverse Aortic Arch Carotid Arteries 6-0 Monofilament Suture
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