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JoVE Journal Cancer Research
A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
 

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice

Article DOI: 10.3791/59358-v • 08:55 min • April 17th, 2019
April 17th, 2019 •
1, 1, 1, 1, 1
1Department of Nuclear Medicine, Netherlands Cancer Institute

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Well-differentiated neuroendocrine tumors overexpress somatostatin receptors which can be utilized for diagnostic imaging with the radiolabeled somatostatin analog 68Ga-DOTATATE. This protocol details the radiolabeling of 68Ga-DOTATATE, quality control, patient preparation, and subsequent PET/CT imaging. Radiation safety and time constrictions due to the short half-life of 68Ga are taken into account.

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Production PET/CT Imaging 68Ga-DOTATATE Neuroendocrine Tumors Clinical Practice Synthesis Quality Control Gallium DOTATATE PET/CT Scan Technique Short Half-life Nuclear Medicine Technologists Patient Administration Labeling Kit Manufacturer's Specifications Materials Manifolds Sterile Vial Non-vented Filter Lead Shield 68-gallium Generator Peptide Analog HEPES Buffer Solution Reaction Vial Lead Shielding
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