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Immunology and Infection

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JoVE Journal Immunology and Infection
Use of the Invertebrate Galleria mellonella as an Infection Model to Study the Mycobacterium tuberculosis Complex
 

Use of the Invertebrate Galleria mellonella as an Infection Model to Study the Mycobacterium tuberculosis Complex

Article DOI: 10.3791/59703-v • 09:23 min • June 30th, 2019
June 30th, 2019 •
*1, *1, 1,2, 1, 3, *1, *1
1Section of Pediatric Infectious Diseases and Allergy, Department of Medicine, Imperial College London, 2Department of Pharmacy, National University of Singapore, 3MRC Centre for Molecular Bacteriology and Infection, Department of Medicine, Imperial College London
* These authors contributed equally

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Galleria mellonella was recently established as a reproducible, cheap, and ethically acceptable infection model for the Mycobacterium tuberculosis complex. Here we describe and demonstrate the steps taken to establish successful infection of G. mellonella with bioluminescent Mycobacterium bovis BCG lux.

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Keywords: Galleria Mellonella Tuberculosis Infection Model Mycobacterium Innate Immunity Alternative To Mammalian Models Bioluminescence BCG Cell Culture Sample Preparation
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