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JoVE Journal Cancer Research
Celcyclus-specifieke meting van γH2AX en apoptosis na genotoxische stress door flow Cytometrie
 
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Celcyclus-specifieke meting van γH2AX en apoptosis na genotoxische stress door flow Cytometrie

Article DOI: 10.3791/59968-v • 08:21 min • September 1st, 2019
September 1st, 2019 •
1,2, 1,2, 1,2, 1,2, 1,2,3, 1,2
1CCU Molecular and Radiation Oncology, German Cancer Research Center, 2Department of Radiation Oncology, Heidelberg University Hospital, 3Department of Radiation Oncology, Freiburg University Medical Center

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De gepresenteerde methode combineert de kwantitatieve analyse van DNA Double-strand Breaks (DSBs), celcyclus verdeling en apoptosis om de celcycluspecifieke evaluatie van de inductie en reparatie van DSB mogelijk te maken, evenals de gevolgen van herstel fouten.

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Kankeronderzoek uitgave 151 DNA-dubbele strand breuken celcyclus verdeling apoptosis DNA-schade respons ioniserende straling koolstofionstraling genotoxische stress Flowcytometrie
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