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Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
 

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Article DOI: 10.3791/60102-v • 11:04 min • September 7th, 2019
September 7th, 2019 •
1, 1, 1, 1, 1
1Department of Chemistry, Texas A&M University-Commerce

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Ion mobility-mass spectrometry and molecular modeling techniques can characterize the selective metal chelating performance of designed metal-binding peptides and the copper-binding peptide methanobactin. Developing new classes of metal chelating peptides will help lead to therapeutics for diseases associated with metal ion misbalance.

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Keywords: Ion Mobility-mass Spectrometry IM-MS Metal Ion Recognition Redox Activity Metal Binding Oligopeptides Molecular Modeling Tertiary Structure Metal Correlation ESI-IM-MS Poly-DL-alanine Alternative Methanobactin PH-dependent Redox Methyl Binding Reaction Product Ions Stoichiometry Protonation State Conformational Structure Metal Chelating Peptides Therapeutics Menkes Disease Wilson's Disease Cancer Alzheimer's Disease Native ESI-IM-MS Negative Ion Positive Ion Acetic Acid Ammonium Hydroxide Mass-to-charge Isotope Pattern
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