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Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
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JoVE Journal Medicina
Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

DOI:
10.3791/61644-v

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09:36 min

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September 24, 2020

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, , , , , , , , , , , , ,
1Department of Perioperative Medicine,CHU Clermont-Ferrand, 2GReD, CNRS, INSERM,Université Clermont Auvergne, 3GRC 29, AP-HP, DMU DREAM, Department of Anesthesiology and Critical Care, Pitié-Salpêtrière Hospital,Sorbonne University, 4Department of Biochemistry and Molecular Genetics,CHU Clermont-Ferrand, 5Division of Allergy, Pulmonary, and Critical Care Medicine,Vanderbilt University Medical Center

Capitoli

  • 00:04Introduciton
  • 00:58Animal Preparation
  • 02:27Acid-Induced Acute Lung Injury
  • 03:04Mechanical Ventilation and Halogenated Anesthetics
  • 05:16Monitoring
  • 07:08Results: Representative Porcine Acute Respiratory Distress Syndrome (ARDS) Evaluation
  • 08:59Conclusion

Summary

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Traduzione automatica

We describe a model of hydrochloric acid-induced acute respiratory distress syndrome (ARDS) in piglets receiving sedation with halogenated agents, isoflurane and sevoflurane, through a device used for inhaled intensive care sedation. This model can be used to investigate the biological mechanisms of halogenated agents on lung injury and repair.

Tags

Porcine ModelAcute Respiratory Distress SyndromeHalogenated AgentICU DeviceCentral Venous AccessFemoral ArteryAcid-induced Lung InjuryMechanical Ventilation

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