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Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
 

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Article DOI: 10.3791/61644-v • 09:36 min • September 24th, 2020
September 24th, 2020 •
1,2, 1,2, 1,2, 1,2, 1,2, 2, 2, 2, 1, 1,2, 1, 3, 2,4, 1,2,5
1Department of Perioperative Medicine, CHU Clermont-Ferrand, 2GReD, CNRS, INSERM, Université Clermont Auvergne, 3GRC 29, AP-HP, DMU DREAM, Department of Anesthesiology and Critical Care, Pitié-Salpêtrière Hospital, Sorbonne University, 4Department of Biochemistry and Molecular Genetics, CHU Clermont-Ferrand, 5Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center

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Summary
Automatic Translation

We describe a model of hydrochloric acid-induced acute respiratory distress syndrome (ARDS) in piglets receiving sedation with halogenated agents, isoflurane and sevoflurane, through a device used for inhaled intensive care sedation. This model can be used to investigate the biological mechanisms of halogenated agents on lung injury and repair.

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Keywords: Porcine Model Acute Respiratory Distress Syndrome Halogenated Agent ICU Device Central Venous Access Femoral Artery Acid-induced Lung Injury Mechanical Ventilation
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