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Bioengineering

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JoVE Journal Bioengineering
Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons
 

Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons

Article DOI: 10.3791/62013-v • 09:54 min • July 14th, 2021
July 14th, 2021 •
1,4, 2,4, 2,4, 1,4, 2,4, 2,4, 3,4, 2,4, 1,4
1Department of Physics, Bar-Ilan University, 2Faculty of Engineering, Bar-Ilan University, 3Department of chemistry, Bar-Ilan University, 4The Institutes of Nanotechnology & Advanced Materials, Bar-Ilan University

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This work presents a bottom-up approach to the engineering of local magnetic forces for control of neuronal organization. Neuron-like cells loaded with magnetic nanoparticles (MNPs) are plated atop and controlled by a micro-patterned platform with perpendicular magnetization. Also described are magnetic characterization, MNP cellular uptake, cell viability, and statistical analysis.

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Keywords: Magnetic Platforms Micron-scale Organization Interconnected Neurons Neural Network Formation Magnetic Manipulations In Vitro Studies Biointerfacing Devices Magnetic Nanoparticles Photolithography Ferromagnetic Multilayers
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