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Avancerad hjärtrytmhantering genom att tillämpa optogenetisk fotostimulering på flera platser i murina hjärtan
 
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Avancerad hjärtrytmhantering genom att tillämpa optogenetisk fotostimulering på flera platser i murina hjärtan

Article DOI: 10.3791/62335-v • 08:43 min • August 26th, 2021
August 26th, 2021 •
*1,2, *1, 8,9, 1,3,4,6, 8,9, 1,5,6,7
1Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, 2Research Electronics Department, Max Planck Institute for Dynamics and Self-Organization, 3Department of Pharmacology and Toxicology, University Medical Center Goettingen, 4Institute for Nonlinear Dynamics, Georg-August-University Goettingen, 5Department of Cardiology and Pneumology, University Medical Center Goettingen, 6German Center for Cardiovascular Research, DZHK e.V., partner site Goettingen, 7Laboratory Animal Science Unit, German Primate Center Leibniz Institute for Primate Research, 8Department of Microsystems Engineering (IMTEK), University of Freiburg, 9Cluster of Excellence BrainLinks-BrainTools, University of Freiburg
* These authors contributed equally

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Detta arbete rapporterar en metod för att kontrollera hjärtrytmen hos intakta murina hjärtan hos transgena channelrhodopsin-2 (ChR2) möss med hjälp av lokal fotostimulering med en mikro-LED-array och samtidig optisk kartläggning av epikardiell membranpotential.

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Medicin Utgåva 174 hjärtoptogenetik optisk kartläggning LED DI-4-ANBDQPQ Blebbistatin channelrhodopsin-2 ChR2
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