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Bioengineering

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JoVE Journal Bioengineering
Isogenic Kidney Glomerulus Chip Engineered from Human Induced Pluripotent Stem Cells
 

Isogenic Kidney Glomerulus Chip Engineered from Human Induced Pluripotent Stem Cells

Article DOI: 10.3791/63821-v • 10:23 min • November 4th, 2022
November 4th, 2022 •
1, 1,2,3,4
1Department of Biomedical Engineering, Pratt School of Engineering, Duke University, 2Department of Medicine, Division of Nephrology, Duke University School of Medicine, 3Department of Cell Biology, Duke University, 4Center for Biomolecular and Tissue Engineering, Duke University

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Presented here is a protocol to engineer a personalized organ-on-a-chip system that recapitulates the structure and function of the kidney glomerular filtration barrier by integrating genetically matched epithelial and vascular endothelial cells differentiated from human induced pluripotent stem cells. This bioengineered system can advance kidney precision medicine and related applications.

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Keywords: Isogenic Glomerulus Chip Human Induced Pluripotent Stem Cells IPSC Glomerular Epithelium Glomerular Endothelium Patient-specific Disease Modeling Nephrotoxicity Testing Precision Medicine Drug Screening Mechanistic Studies Body-on-a-chip Patient-specific Responses Basement Membrane Matrix Vascular Endothelial Cells Microfluidic Chip PDMS Membrane
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