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Genetics

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JoVE Journal Genetics
Mapping Mammalian 3D Genome Interactions with Micro-C-XL
 

Mapping Mammalian 3D Genome Interactions with Micro-C-XL

Article DOI: 10.3791/64579-v • 11:41 min • November 3rd, 2023
November 3rd, 2023 •
1, 1, 1
1Novo Nordisk Foundation Center for Protein Research, University of Copenhagen

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A protocol for mapping the three-dimensional genome organization with nucleosome resolution using the genome-wide chromosome conformation capture method Micro-C-XL is presented here.

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Keywords: 3D Genome Micro-C-XL MNase Titration Nucleosome Resolution Chromatin Digestion DNA Purification Agarose Gel Electrophoresis
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