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Cancer Research

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JoVE Journal Cancer Research
Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors
 

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Article DOI: 10.3791/64606-v • 15:24 min • December 16th, 2022
December 16th, 2022 •
*1, *1, 1, 1, 2, 2, 3, 1, 2, 1
1Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver Anschutz Medical Campus, 2Division of Oncology, School of Medicine, University of Colorado Denver Anschutz Medical Campus, 3Department of Medical Oncology, Catalan Institute of Oncology (ICO-L'Hospitalet)
* These authors contributed equally

Capitoli

Riepilogo
Automatic Translation

This protocol outlines the generation of human immune system (HIS) mice for immuno-oncology studies. Instructions and considerations in the use of this model for testing human immunotherapeutics on human tumors implanted in this model are presented with an emphasis on characterizing the response of the human immune system to the tumor.

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Keywords: Humanized Mouse Model Human Tumor Immunotherapy CD34-positive Cells Cord Blood Cell Expansion Cell Separation Flow Cytometry Preclinical Model Immuno-oncology
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