Aurora Esquela-Kerscher Department of Microbiology and Molecular Cell Biology Eastern Virginia Medical School Biography Publications Institution JoVE Articles Aurora Esquela-Kerscher Aurora Esquela Kerscher’s laboratory aims to understand how noncoding RNA networks influence cancer progression and metastasis in human cells. Dr. Kerscher received her B.A. in Biology from Washington University in St Louis, Missouri in 1992 and completed a M.S. in Biotechnology in 1996 at the Johns Hopkins University in Baltimore, Maryland. In 2003, she earned a Ph.D. in Biochemistry, Cellular, and Molecular Biology at the Johns Hopkins School of Medicine. Her Ph.D. thesis work in Dr. Se-Jin Lee’s laboratory provided her with a firm foundation in mammalian development utilizing mouse models to elucidate the function of novel members of the TGF-Beta Family in liver and kidney organogenesis. Dr. Kerscher’s interest in microRNAs and their role in development and disease began during her postdoctoral fellowship in Dr. Frank Slack’s laboratory at Yale University in New Haven, Connecticut. In 2007, Dr. Kerscher joined the faculty at Eastern Virginia Medical School in Norfolk, Virginia and continued her research studying microRNAs and cancer. Dr. Kerscher is currently an Associate Professor in the Department of Microbiology and Molecular Cell Biology at EVMS and a member of the Leroy T. Canoles Jr. Cancer Research Center. EVMS houses one of the largest clinically defined urological biorepositories in the nation. Her lab has taken advantage of this unique resource and identified a subset of microRNAs that are closely associated with advanced forms of human prostate cancer. Her group aims to translate their work into effective clinical tools for aggressive and drug resistant from of prostate cancer. Publications Plasmonic-Based Biosensor for the Early Diagnosis of Prostate Cancer ACS Omega. Jan, 2022 | Pubmed ID: 35071928 Detection of Rapidly Accumulating Stress-induced SUMO in Prostate Cancer Cells by a Fluorescent SUMO Biosensor Molecular Carcinogenesis. 12, 2021 | Pubmed ID: 34559929 GDF11 Induces Kidney Fibrosis, Renal Cell Epithelial-to-mesenchymal Transition, and Kidney Dysfunction and Failure Surgery. 08, 2018 | Pubmed ID: 29731246 Characterization and Evidence of the MiR-888 Cluster As a Novel Cancer Network in Prostate Molecular Cancer Research : MCR. 04, 2018 | Pubmed ID: 29330297 The Lin-4 MicroRNA: The Ultimate Micromanager Cell Cycle (Georgetown, Tex.). Month, 2014 | Pubmed ID: 24584060 MiR-888 is an Expressed Prostatic Secretions-derived MicroRNA That Promotes Prostate Cell Growth and Migration Cell Cycle (Georgetown, Tex.). Month, 2014 | Pubmed ID: 24200968 Gongylonema Pulchrum Infection in a Resident of Williamsburg, Virginia, Verified by Genetic Analysis The American Journal of Tropical Medicine and Hygiene. Oct, 2013 | Pubmed ID: 23958907 A Growing Molecular Toolbox for the Functional Analysis of MicroRNAs in Caenorhabditis Elegans Briefings in Functional Genomics. Jul, 2011 | Pubmed ID: 21624898 The Complexities of MicroRNA Regulation: Mirandering Around the Rules The International Journal of Biochemistry & Cell Biology. Aug, 2010 | Pubmed ID: 19800023 CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis Charlotte Chambers1, Linh Quan1, Grace Yi1, Aurora Esquela-Kerscher1 1Department of Microbiology & Molecular Cell Biology, Leroy T. Canoles Jr. Cancer Research Center, Eastern Virginia Medical School JoVE 63704 생물학
CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis Charlotte Chambers1, Linh Quan1, Grace Yi1, Aurora Esquela-Kerscher1 1Department of Microbiology & Molecular Cell Biology, Leroy T. Canoles Jr. Cancer Research Center, Eastern Virginia Medical School JoVE 63704 생물학