Edgars Liepinsh Laboratory of Pharmaceutical Pharmacology Latvian Institute of Organic Synthesis Biography Publications Institution JoVE Articles Edgars Liepinsh has not added a biography. If you are Edgars Liepinsh and would like to personalize this page please email our Author Liaison for assistance. Publications Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19 International Journal of Molecular Sciences. Dec, 2021 | Pubmed ID: 35008470 Antibacterial Activity of Apramycin at Acidic PH Warrants Wide Therapeutic Window in the Treatment of Complicated Urinary Tract Infections and Acute Pyelonephritis EBioMedicine. Nov, 2021 | Pubmed ID: 34740109 Low Cardiac Content of Long-chain Acylcarnitines in TMLHE Knockout Mice Prevents Ischaemia-reperfusion-induced Mitochondrial and Cardiac Damage Free Radical Biology & Medicine. 12, 2021 | Pubmed ID: 34728372 Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects Against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats Oxidative Medicine and Cellular Longevity. 2021 | Pubmed ID: 34367467 Long-Chain Acylcarnitines Decrease the Phosphorylation of the Insulin Receptor at Tyr1151 Through a PTP1B-Dependent Mechanism International Journal of Molecular Sciences. Jun, 2021 | Pubmed ID: 34208786 Energy Substrate Metabolism and Mitochondrial Oxidative Stress in Cardiac Ischemia/reperfusion Injury Free Radical Biology & Medicine. 03, 2021 | Pubmed ID: 33484825 Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin Clinical Pharmacology and Therapeutics. 04, 2021 | Pubmed ID: 33150591 Rats with Congenital Hydronephrosis Show Increased Susceptibility to Renal Ischemia-reperfusion Injury Physiological Reports. 11, 2020 | Pubmed ID: 33207081 Inhibition of CPT2 Exacerbates Cardiac Dysfunction and Inflammation in Experimental Endotoxaemia Journal of Cellular and Molecular Medicine. 10, 2020 | Pubmed ID: 32896106 Metformin Decreases Bacterial Trimethylamine Production and Trimethylamine N-oxide Levels in Db/db Mice Scientific Reports. 09, 2020 | Pubmed ID: 32884086 Low-intensity Exercise Stimulates Bioenergetics and Increases Fat Oxidation in Mitochondria of Blood Mononuclear Cells from Sedentary Adults Physiological Reports. 06, 2020 | Pubmed ID: 32562386 Empagliflozin Protects Cardiac Mitochondrial Fatty Acid Metabolism in a Mouse Model of Diet-Induced Lipid Overload Cardiovascular Drugs and Therapy. 12, 2020 | Pubmed ID: 32424653 Cardiac Metabolism As a Driver and Therapeutic Target of Myocardial Infarction Journal of Cellular and Molecular Medicine. 06, 2020 | Pubmed ID: 32384583 Excretion of the Polymyxin Derivative NAB739 in Murine Urine Antibiotics (Basel, Switzerland). Mar, 2020 | Pubmed ID: 32230751 Altered Mitochondrial Metabolism in the Insulin-resistant Heart Acta Physiologica (Oxford, England). 03, 2020 | Pubmed ID: 31840389 Decreases in Circulating Concentrations of Long-Chain Acylcarnitines and Free Fatty Acids During the Glucose Tolerance Test Represent Tissue-Specific Insulin Sensitivity Frontiers in Endocrinology. 2019 | Pubmed ID: 31920980 Mitochondrial Function in the Kidney and Heart, but Not the Brain, is Mainly Altered in an Experimental Model of Endotoxaemia Shock (Augusta, Ga.). 12, 2019 | Pubmed ID: 30640252 Letter to the Editor: "Serum Carnitine Metabolites and Incident Type 2 Diabetes Mellitus in Patients With Suspected Stable Angina Pectoris" The Journal of Clinical Endocrinology and Metabolism. 11, 2018 | Pubmed ID: 30124877 Plasma Acylcarnitine Concentrations Reflect the Acylcarnitine Profile in Cardiac Tissues Scientific Reports. 12, 2017 | Pubmed ID: 29235526 Acute and Long-term Administration of Palmitoylcarnitine Induces Muscle-specific Insulin Resistance in Mice BioFactors (Oxford, England). Sep, 2017 | Pubmed ID: 28759135 S-phenylpiracetam, a Selective DAT Inhibitor, Reduces Body Weight Gain Without Influencing Locomotor Activity Pharmacology, Biochemistry, and Behavior. 09, 2017 | Pubmed ID: 28743458 Decrease in Long-Chain Acylcarnitine Tissue Content Determines the Duration of and Correlates with the Cardioprotective Effect of Methyl-GBB Basic & Clinical Pharmacology & Toxicology. Aug, 2017 | Pubmed ID: 28244203 Trimethylamine N-oxide Impairs Pyruvate and Fatty Acid Oxidation in Cardiac Mitochondria Toxicology Letters. Feb, 2017 | Pubmed ID: 28049038 Carnitine and γ-Butyrobetaine Stimulate Elimination of Meldonium Due to Competition for OCTN2-mediated Transport Basic & Clinical Pharmacology & Toxicology. May, 2017 | Pubmed ID: 27983775 Response to Comment by Sergei V. Jargin: "Meldonium (Mildronate): Primum Nоn Nocere" Pharmacological Research. Dec, 2016 | Pubmed ID: 27725311 The Unusual Pharmacokinetics of Meldonium: Implications for Doping Pharmacological Research. Sep, 2016 | Pubmed ID: 27262679 Long-chain Acylcarnitines Determine Ischaemia/reperfusion-induced Damage in Heart Mitochondria The Biochemical Journal. 05, 2016 | Pubmed ID: 26936967 Pharmacological Effects of Meldonium: Biochemical Mechanisms and Biomarkers of Cardiometabolic Activity Pharmacological Research. 11, 2016 | Pubmed ID: 26850121 Decreased Acylcarnitine Content Improves Insulin Sensitivity in Experimental Mice Models of Insulin Resistance Pharmacological Research. 11, 2016 | Pubmed ID: 26621248 The Neuroprotective Effects of R-phenibut After Focal Cerebral Ischemia Pharmacological Research. 11, 2016 | Pubmed ID: 26621244 Structure and Function of CutC Choline Lyase from Human Microbiota Bacterium Klebsiella Pneumoniae The Journal of Biological Chemistry. Aug, 2015 | Pubmed ID: 26187464 Methyl-γ-butyrobetaine Decreases Levels of Acylcarnitines and Attenuates the Development of Atherosclerosis Vascular Pharmacology. Sep, 2015 | Pubmed ID: 25989106 Determination of Trimethylamine-N-oxide in Combination with L-carnitine and γ-butyrobetaine in Human Plasma by UPLC/MS/MS Biomedical Chromatography : BMC. Nov, 2015 | Pubmed ID: 25873316 Suppression of Intestinal Microbiota-dependent Production of Pro-atherogenic Trimethylamine N-oxide by Shifting L-carnitine Microbial Degradation Life Sciences. Nov, 2014 | Pubmed ID: 25301199 A Cross-sectional Survey of Urinary Iodine Status in Latvia Medicina (Kaunas, Lithuania). 2014 | Pubmed ID: 25172607 Long-chain Acylcarnitine Content Determines the Pattern of Energy Metabolism in Cardiac Mitochondria Molecular and Cellular Biochemistry. Oct, 2014 | Pubmed ID: 24878991 Selective Inhibition of OCTN2 is More Effective Than Inhibition of Gamma-butyrobetaine Dioxygenase to Decrease the Availability of L-carnitine and to Reduce Myocardial Infarct Size Pharmacological Research. Jul, 2014 | Pubmed ID: 24836867 Magnesium Nitrate Attenuates Blood Pressure Rise in SHR Rats Magnesium Research. Jan-Mar, 2014 | Pubmed ID: 24827813 Mildronate, the Inhibitor of L-carnitine Transport, Induces Brain Mitochondrial Uncoupling and Protects Against Anoxia-reoxygenation European Journal of Pharmacology. Jan, 2014 | Pubmed ID: 24333219 The Heart is Better Protected Against Myocardial Infarction in the Fed State Compared to the Fasted State Metabolism: Clinical and Experimental. Jan, 2014 | Pubmed ID: 24140100 Activated Peroxisomal Fatty Acid Metabolism Improves Cardiac Recovery in Ischemia-reperfusion Naunyn-Schmiedeberg's Archives of Pharmacology. Jun, 2013 | Pubmed ID: 23525500 Association of Reduced Glyoxalase 1 Activity and Painful Peripheral Diabetic Neuropathy in Type 1 and 2 Diabetes Mellitus Patients Journal of Diabetes and Its Complications. May-Jun, 2013 | Pubmed ID: 23351995 Troubleshooting Digital Macro Photography for Image Acquisition and the Analysis of Biological Samples Journal of Pharmacological and Toxicological Methods. Mar-Apr, 2013 | Pubmed ID: 23202591 Glyoxalase 1 and Glyoxalase 2 Activities in Blood and Neuronal Tissue Samples from Experimental Animal Models of Obesity and Type 2 Diabetes Mellitus The Journal of Physiological Sciences : JPS. Nov, 2012 | Pubmed ID: 22893478 High L-carnitine Concentrations Do Not Prevent Late Diabetic Complications in Type 1 and 2 Diabetic Patients Nutrition Research (New York, N.Y.). May, 2012 | Pubmed ID: 22652370 The Sensorimotor and Cognitive Deficits in Rats Following 90- and 120-min Transient Occlusion of the Middle Cerebral Artery Journal of Neuroscience Methods. Jul, 2012 | Pubmed ID: 22640751 A Short-term High-dose Administration of Sodium Pivalate Impairs Pyruvate Metabolism Without Affecting Cardiac Function Cardiovascular Toxicology. Dec, 2012 | Pubmed ID: 22539084 The Cardioprotective Effect of Mildronate is Diminished After Co-treatment with L-carnitine Journal of Cardiovascular Pharmacology and Therapeutics. Jun, 2012 | Pubmed ID: 21903968 Administration of L-carnitine and Mildronate Improves Endothelial Function and Decreases Mortality in Hypertensive Dahl Rats Pharmacological Reports : PR. 2011 | Pubmed ID: 21857086 Mildronate Treatment Alters γ-butyrobetaine and L-carnitine Concentrations in Healthy Volunteers The Journal of Pharmacy and Pharmacology. Sep, 2011 | Pubmed ID: 21827492 Mildronate Treatment Improves Functional Recovery Following Middle Cerebral Artery Occlusion in Rats Behavioural Brain Research. Sep, 2011 | Pubmed ID: 21420440 Anti-diabetic Effects of Mildronate Alone or in Combination with Metformin in Obese Zucker Rats European Journal of Pharmacology. May, 2011 | Pubmed ID: 21371472 Flow Cytometric Analysis of Glyoxalase-1 Expression in Human Leukocytes Cell Biochemistry and Function. Mar, 2011 | Pubmed ID: 21370249 Mildronate Exerts Acute Anticonvulsant and Antihypnotic Effects Behavioural Pharmacology. Sep, 2010 | Pubmed ID: 20661137 The Anti-inflammatory and Antinociceptive Effects of NF-kappaB Inhibitory Guanidine Derivative ME10092 International Immunopharmacology. Apr, 2010 | Pubmed ID: 20074673 Inhibition of Carnitine Acetyltransferase by Mildronate, a Regulator of Energy Metabolism Journal of Enzyme Inhibition and Medicinal Chemistry. Dec, 2009 | Pubmed ID: 19912061 Effects of Long-term Mildronate Treatment on Cardiac and Liver Functions in Rats Basic & Clinical Pharmacology & Toxicology. Dec, 2009 | Pubmed ID: 19663820 Protective Effects of Mildronate in an Experimental Model of Type 2 Diabetes in Goto-Kakizaki Rats British Journal of Pharmacology. Aug, 2009 | Pubmed ID: 19594753 Myocardial Infarct Size-limiting and Anti-arrhythmic Effects of Mildronate Orotate in the Rat Heart Cardiovascular Drugs and Therapy. Aug, 2009 | Pubmed ID: 19536647 Quantitative Analysis of Phenibut in Rat Brain Tissue Extracts by Liquid Chromatography-tandem Mass Spectrometry Biomedical Chromatography : BMC. Dec, 2008 | Pubmed ID: 19034959 Mildronate Decreases Carnitine Availability and Up-regulates Glucose Uptake and Related Gene Expression in the Mouse Heart Life Sciences. Oct, 2008 | Pubmed ID: 18801379 Effect of Inhibiting Carnitine Biosynthesis on Male Rat Sexual Performance Physiology & Behavior. Oct, 2008 | Pubmed ID: 18640137 Comparative Pharmacological Activity of Optical Isomers of Phenibut European Journal of Pharmacology. Mar, 2008 | Pubmed ID: 18275958 Mildronate, an Inhibitor of Carnitine Biosynthesis, Induces an Increase in Gamma-butyrobetaine Contents and Cardioprotection in Isolated Rat Heart Infarction Journal of Cardiovascular Pharmacology. Dec, 2006 | Pubmed ID: 17204911 Investigations on the Pharmacology of the Cardioprotective Guanidine ME10092 Journal of Cardiovascular Pharmacology. Aug, 2004 | Pubmed ID: 15243298 The Methylester of Gamma-butyrobetaine, but Not Gamma-butyrobetaine Itself, Induces Muscarinic Receptor-dependent Vasodilatation Naunyn-Schmiedeberg's Archives of Pharmacology. May, 2004 | Pubmed ID: 15060760 Mildronate: Cardioprotective Action Through Carnitine-lowering Effect Trends in Cardiovascular Medicine. Aug, 2002 | Pubmed ID: 12242052 Rodent Heart and Brain Tissue Preparation for Digital Macro Photography after Ischemia-reperfusion Edgars Liepinsh1, Janis Kuka1, Liga Zvejniece1, Reinis Vilskersts1, Maija Dambrova1 1Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis JoVE 62942 의학
Rodent Heart and Brain Tissue Preparation for Digital Macro Photography after Ischemia-reperfusion Edgars Liepinsh1, Janis Kuka1, Liga Zvejniece1, Reinis Vilskersts1, Maija Dambrova1 1Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis JoVE 62942 의학