John M. Coffin Department of Molecular Biology and Microbiology Tuffts University Biography Publications Institution JoVE Articles John M. Coffin has not added a biography. If you are John M. Coffin and would like to personalize this page please email our Author Liaison for assistance. Publications Restricted Replication of Xenotropic Murine Leukemia Virus-Related Virus in Pigtailed Macaques Journal of Virology. Jan, 2012 | Pubmed ID: 22238316 Characterization, Mapping, and Distribution of the Two XMRV Parental Proviruses Journal of Virology. Jan, 2012 | Pubmed ID: 22031947 Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples Advances in Virology. 2011 | Pubmed ID: 22312358 Short-course Combivir After Single-dose Nevirapine Reduces but Does Not Eliminate the Emergence of Nevirapine Resistance in Women Antiviral Therapy. Nov, 2011 | Pubmed ID: 22293443 Binding of More Than One Tva800 Molecule is Required for ASLV-A Entry Retrovirology. 2011 | Pubmed ID: 22099981 Identification, Characterization, and Comparative Genomic Distribution of the HERV-K (HML-2) Group of Human Endogenous Retroviruses Retrovirology. 2011 | Pubmed ID: 22067224 Failure to Confirm XMRV/MLVs in the Blood of Patients with Chronic Fatigue Syndrome: a Multi-laboratory Study Science (New York, N.Y.). Nov, 2011 | Pubmed ID: 21940862 Majority of CD4+ T Cells from Peripheral Blood of HIV-1-infected Individuals Contain Only One HIV DNA Molecule Proceedings of the National Academy of Sciences of the United States of America. Jul, 2011 | Pubmed ID: 21690402 Recombinant Origin of the Retrovirus XMRV Science (New York, N.Y.). Jul, 2011 | Pubmed ID: 21628392 Role of Low-frequency HIV-1 Variants in Failure of Nevirapine-containing Antiviral Therapy in Women Previously Exposed to Single-dose Nevirapine Proceedings of the National Academy of Sciences of the United States of America. May, 2011 | Pubmed ID: 21576473 Estimate of Effective Recombination Rate and Average Selection Coefficient for HIV in Chronic Infection Proceedings of the National Academy of Sciences of the United States of America. Apr, 2011 | Pubmed ID: 21436045 Clonal Sequences Recovered from Plasma from Patients with Residual HIV-1 Viremia and on Intensified Antiretroviral Therapy Are Identical to Replicating Viral RNAs Recovered from Circulating Resting CD4+ T Cells Journal of Virology. May, 2011 | Pubmed ID: 21367910 The Blood Xenotropic Murine Leukemia Virus-Related Virus Scientific Research Working Group: Mission, Progress, and Plans Transfusion. Mar, 2011 | Pubmed ID: 21366602 Genetic Diversity of Simian Immunodeficiency Virus Encoding HIV-1 Reverse Transcriptase Persists in Macaques Despite Antiretroviral Therapy Journal of Virology. Jan, 2011 | Pubmed ID: 21084490 Contamination of Human DNA Samples with Mouse DNA Can Lead to False Detection of XMRV-like Sequences Retrovirology. 2010 | Pubmed ID: 21171973 Mouse DNA Contamination in Human Tissue Tested for XMRV Retrovirology. 2010 | Pubmed ID: 21171966 HIV-1 Continues to Replicate and Evolve in Patients with Natural Control of HIV Infection Journal of Virology. Dec, 2010 | Pubmed ID: 20926564 The Effect of Raltegravir Intensification on Low-level Residual Viremia in HIV-infected Patients on Antiretroviral Therapy: a Randomized Controlled Trial PLoS Medicine. 2010 | Pubmed ID: 20711481 Patterns of Human Immunodeficiency Virus Type 1 Recombination Ex Vivo Provide Evidence for Coadaptation of Distant Sites, Resulting in Purifying Selection for Intersubtype Recombinants During Replication Journal of Virology. Aug, 2010 | Pubmed ID: 20504919 Comparison of Standard PCR/cloning to Single Genome Sequencing for Analysis of HIV-1 Populations Journal of Virological Methods. Sep, 2010 | Pubmed ID: 20451557 Tumors Induced in Mice by Direct Inoculation of Plasmid DNA Expressing Both Activated H-ras and C-myc International Journal of Biological Sciences. 2010 | Pubmed ID: 20376206 Flexible Use of Nuclear Import Pathways by HIV-1 Cell Host & Microbe. Mar, 2010 | Pubmed ID: 20227665 Antiretroviral Intensification and Valproic Acid Lack Sustained Effect on Residual HIV-1 Viremia or Resting CD4+ Cell Infection PloS One. 2010 | Pubmed ID: 20186346 Multi-site Adaptation in the Presence of Infrequent Recombination Theoretical Population Biology. May, 2010 | Pubmed ID: 20149814 Low Frequency Nonnucleoside Reverse-transcriptase Inhibitor-resistant Variants Contribute to Failure of Efavirenz-containing Regimens in Treatment- Experienced Patients The Journal of Infectious Diseases. Mar, 2010 | Pubmed ID: 20102272 Endogenous Non-retroviral RNA Virus Elements in Mammalian Genomes Nature. Jan, 2010 | Pubmed ID: 20054395 Optimization of Allele-specific PCR Using Patient-specific HIV Consensus Sequences for Primer Design Journal of Virological Methods. Mar, 2010 | Pubmed ID: 19948190 RT-SHIV Subpopulation Dynamics in Infected Macaques During Anti-HIV Therapy Retrovirology. 2009 | Pubmed ID: 19889213 Virology. A New Virus for Old Diseases? Science (New York, N.Y.). Oct, 2009 | Pubmed ID: 19815721 Persistent Low-level Viremia in HIV-1 Elite Controllers and Relationship to Immunologic Parameters The Journal of Infectious Diseases. Sep, 2009 | Pubmed ID: 19656066 High Efficiency of HIV-1 Genomic RNA Packaging and Heterozygote Formation Revealed by Single Virion Analysis Proceedings of the National Academy of Sciences of the United States of America. Aug, 2009 | Pubmed ID: 19628694 Likely Role of APOBEC3G-mediated G-to-A Mutations in HIV-1 Evolution and Drug Resistance PLoS Pathogens. Apr, 2009 | Pubmed ID: 19343218 Regimen Simplification to Atazanavir-ritonavir Alone As Maintenance Antiretroviral Therapy: Final 48-week Clinical and Virologic Outcomes The Journal of Infectious Diseases. Mar, 2009 | Pubmed ID: 19191590 Lytic Granule Loading of CD8+ T Cells is Required for HIV-infected Cell Elimination Associated with Immune Control Immunity. Dec, 2008 | Pubmed ID: 19062316 Attenuation by a Thousand Cuts The New England Journal of Medicine. Nov, 2008 | Pubmed ID: 19020330 Host-retrovirus Arms Race: Trimming the Budget Cell Host & Microbe. Sep, 2008 | Pubmed ID: 18779045 Effects of Retroviruses on Host Genome Function Annual Review of Genetics. 2008 | Pubmed ID: 18694346 HIV-1 Reverse Transcriptase Connection Subdomain Mutations Reduce Template RNA Degradation and Enhance AZT Excision Proceedings of the National Academy of Sciences of the United States of America. Aug, 2008 | Pubmed ID: 18667707 Valproic Acid Without Intensified Antiviral Therapy Has Limited Impact on Persistent HIV Infection of Resting CD4+ T Cells AIDS (London, England). Jun, 2008 | Pubmed ID: 18525258 Interactions of Murine APOBEC3 and Human APOBEC3G with Murine Leukemia Viruses Journal of Virology. Jul, 2008 | Pubmed ID: 18448535 Low-level Viremia Persists for at Least 7 Years in Patients on Suppressive Antiretroviral Therapy Proceedings of the National Academy of Sciences of the United States of America. Mar, 2008 | Pubmed ID: 18332425 Frequent Polymorphism at Drug Resistance Sites in HIV-1 Protease and Reverse Transcriptase AIDS (London, England). Feb, 2008 | Pubmed ID: 18301062 Oncogenicity of DNA in Vivo: Tumor Induction with Expression Plasmids for Activated H-ras and C-myc Biologicals : Journal of the International Association of Biological Standardization. May, 2008 | Pubmed ID: 18218323 Role of APOBEC3 in Genetic Diversity Among Endogenous Murine Leukemia Viruses PLoS Genetics. Oct, 2007 | Pubmed ID: 17967065 Upregulation of CTLA-4 by HIV-specific CD4+ T Cells Correlates with Disease Progression and Defines a Reversible Immune Dysfunction Nature Immunology. Nov, 2007 | Pubmed ID: 17906628 Suppression of Viremia and Evolution of Human Immunodeficiency Virus Type 1 Drug Resistance in a Macaque Model for Antiretroviral Therapy Journal of Virology. Nov, 2007 | Pubmed ID: 17855539 ART Suppresses Plasma HIV-1 RNA to a Stable Set Point Predicted by Pretherapy Viremia PLoS Pathogens. Apr, 2007 | Pubmed ID: 17411338 Mutations in the Connection Domain of HIV-1 Reverse Transcriptase Increase 3'-azido-3'-deoxythymidine Resistance Proceedings of the National Academy of Sciences of the United States of America. Jan, 2007 | Pubmed ID: 17179211 Blinded, Multicenter Comparison of Methods to Detect a Drug-resistant Mutant of Human Immunodeficiency Virus Type 1 at Low Frequency Journal of Clinical Microbiology. Jul, 2006 | Pubmed ID: 16825395 Selection and Persistence of Non-nucleoside Reverse Transcriptase Inhibitor-resistant HIV-1 in Patients Starting and Stopping Non-nucleoside Therapy AIDS (London, England). Mar, 2006 | Pubmed ID: 16514300 Evolution of Broad Host Range in Retroviruses Leads to Cell Death Mediated by Highly Cytopathic Variants Journal of Virology. Jan, 2006 | Pubmed ID: 16378958 Human Endogenous Retroviral Elements As Indicators of Ectopic Recombination Events in the Primate Genome Genetics. Nov, 2005 | Pubmed ID: 16157677 Depletion of Latent HIV-1 Infection in Vivo: a Proof-of-concept Study Lancet. Aug 13-19, 2005 | Pubmed ID: 16099290 Characterization of Hortulanus Endogenous Murine Leukemia Virus, an Endogenous Provirus That Encodes an Infectious Murine Leukemia Virus of a Novel Subgroup Journal of Virology. Jul, 2005 | Pubmed ID: 15956577 Symmetrical Base Preferences Surrounding HIV-1, Avian Sarcoma/leukosis Virus, and Murine Leukemia Virus Integration Sites Proceedings of the National Academy of Sciences of the United States of America. Apr, 2005 | Pubmed ID: 15802467 Mechanism for Nucleoside Analog-mediated Abrogation of HIV-1 Replication: Balance Between RNase H Activity and Nucleotide Excision Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005 | Pubmed ID: 15684061 Relationship Between Retroviral DNA-integration-site Selection and Host Cell Transcription Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005 | Pubmed ID: 15659548 Multiple, Linked Human Immunodeficiency Virus Type 1 Drug Resistance Mutations in Treatment-experienced Patients Are Missed by Standard Genotype Analysis Journal of Clinical Microbiology. Jan, 2005 | Pubmed ID: 15635002 In Vitro Characterization of a Simian Immunodeficiency Virus-human Immunodeficiency Virus (HIV) Chimera Expressing HIV Type 1 Reverse Transcriptase to Study Antiviral Resistance in Pigtail Macaques Journal of Virology. Dec, 2004 | Pubmed ID: 15564466 Evolution of Retroviruses: Fossils in Our DNA Proceedings of the American Philosophical Society. Sep, 2004 | Pubmed ID: 15551500 Single-strand Specificity of APOBEC3G Accounts for Minus-strand Deamination of the HIV Genome Nature Structural & Molecular Biology. May, 2004 | Pubmed ID: 15098018 Human Endogenous Retrovirus K Solo-LTR Formation and Insertional Polymorphisms: Implications for Human and Viral Evolution Proceedings of the National Academy of Sciences of the United States of America. Feb, 2004 | Pubmed ID: 14757818 Nonrandom HIV-1 Infection and Double Infection Via Direct and Cell-mediated Pathways Proceedings of the National Academy of Sciences of the United States of America. Jan, 2004 | Pubmed ID: 14707263 New Real-time Reverse Transcriptase-initiated PCR Assay with Single-copy Sensitivity for Human Immunodeficiency Virus Type 1 RNA in Plasma Journal of Clinical Microbiology. Oct, 2003 | Pubmed ID: 14532178 Virology. Weapons of Mutational Destruction Science (New York, N.Y.). Aug, 2003 | Pubmed ID: 12920286 Mechanisms of Avian Retroviral Host Range Extension Journal of Virology. Jun, 2003 | Pubmed ID: 12767991 The Solitary Wave of Asexual Evolution Proceedings of the National Academy of Sciences of the United States of America. Jan, 2003 | Pubmed ID: 12525686 A Novel Endogenous Retrovirus-related Element in the Human Genome Resembles a DNA Transposon: Evidence for an Evolutionary Link? Genomics. Nov, 2002 | Pubmed ID: 12408960 Proposed Alternatives for the Use of Anti-HIV Drugs: is It Appropriate? Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. Feb, 1999 | Pubmed ID: 11504471 Amplifying और मानक नैदानिक Assays द्वारा जांच की सीमा से नीचे वायरल लोड के साथ एचआईवी संक्रमित व्यक्तियों में एचआईवी -1 शाही सेना बढ़ाता Helene Mens1, Mary Kearney1, Ann Wiegand1, Jonathan Spindler1, Frank Maldarelli1, John W. Mellors2, John M. Coffin3 1The virology Core at the HIV Drug Resistance Program, NCI-Frederick, 2Division of Infectious Diseases, University of Pittsburgh, 3Department of Molecular Biology and Microbiology, Tuffts University JoVE 2960 면역학 및 감염병학
Amplifying और मानक नैदानिक Assays द्वारा जांच की सीमा से नीचे वायरल लोड के साथ एचआईवी संक्रमित व्यक्तियों में एचआईवी -1 शाही सेना बढ़ाता Helene Mens1, Mary Kearney1, Ann Wiegand1, Jonathan Spindler1, Frank Maldarelli1, John W. Mellors2, John M. Coffin3 1The virology Core at the HIV Drug Resistance Program, NCI-Frederick, 2Division of Infectious Diseases, University of Pittsburgh, 3Department of Molecular Biology and Microbiology, Tuffts University JoVE 2960 면역학 및 감염병학