Noah Weisleder Davis Heart & Lung Research Institute, Department of Physiology and Cell Biology The Ohio State University Biography Publications Institution JoVE Articles Noah Weisleder has not added a biography. If you are Noah Weisleder and would like to personalize this page please email our Author Liaison for assistance. Publications Novel Excitation-contraction Coupling Related Genes Reveal Aspects of Muscle Weakness Beyond Atrophy-new Hopes for Treatment of Musculoskeletal Diseases Frontiers in Physiology. 2014 | Pubmed ID: 24600395 TRIM Proteins in Therapeutic Membrane Repair of Muscular Dystrophy JAMA Neurology. Jul, 2013 | Pubmed ID: 23699904 A Dual Mode Pulsed Electro-magnetic Cell Stimulator Produces Acceleration of Myogenic Differentiation Recent Patents on Biotechnology. Apr, 2013 | Pubmed ID: 23445453 Type 1 Inositol (1,4,5)-trisphosphate Receptor Activates Ryanodine Receptor 1 to Mediate Calcium Spark Signaling in Adult Mammalian Skeletal Muscle The Journal of Biological Chemistry. Jan, 2013 | Pubmed ID: 23223241 Orai1 Mediates Exacerbated Ca(2+) Entry in Dystrophic Skeletal Muscle PloS One. 2012 | Pubmed ID: 23185465 Poloxamer 188 (p188) As a Membrane Resealing Reagent in Biomedical Applications Recent Patents on Biotechnology. Dec, 2012 | Pubmed ID: 23092436 Recombinant MG53 Protein Modulates Therapeutic Cell Membrane Repair in Treatment of Muscular Dystrophy Science Translational Medicine. Jun, 2012 | Pubmed ID: 22723464 Enhancing Muscle Membrane Repair by Gene Delivery of MG53 Ameliorates Muscular Dystrophy and Heart Failure in δ-Sarcoglycan-deficient Hamsters Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2012 | Pubmed ID: 22314291 Nonmuscle Myosin IIA Facilitates Vesicle Trafficking for MG53-mediated Cell Membrane Repair The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jan, 2012 | Pubmed ID: 22253476 Detection of Calcium Sparks in Intact and Permeabilized Skeletal Muscle Fibers Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22130850 Store-operated Calcium Entry is Present in HL-1 Cardiomyocytes and Contributes to Resting Calcium Biochemical and Biophysical Research Communications. Dec, 2011 | Pubmed ID: 22079292 Disrupted Membrane Structure and Intracellular Ca²⺠Signaling in Adult Skeletal Muscle with Acute Knockdown of Bin1 PloS One. 2011 | Pubmed ID: 21984944 Mitochondrial Calcium Uptake Regulates Rapid Calcium Transients in Skeletal Muscle During Excitation-contraction (E-C) Coupling The Journal of Biological Chemistry. Sep, 2011 | Pubmed ID: 21795684 Store-operated Ca(2+) Entry (SOCE) Contributes to Normal Skeletal Muscle Contractility in Young but Not in Aged Skeletal Muscle Aging. Jun, 2011 | Pubmed ID: 21666285 Imaging Superoxide Flash and Metabolism-coupled Mitochondrial Permeability Transition in Living Animals Cell Research. Sep, 2011 | Pubmed ID: 21556035 Redox-dependent Oligomerization Through a Leucine Zipper Motif is Essential for MG53-mediated Cell Membrane Repair American Journal of Physiology. Cell Physiology. Jul, 2011 | Pubmed ID: 21525429 A Versatile Single-plasmid System for Tissue-specific and Inducible Control of Gene Expression in Transgenic Mice FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2011 | Pubmed ID: 21518849 Dysferlin, Annexin A1, and Mitsugumin 53 Are Upregulated in Muscular Dystrophy and Localize to Longitudinal Tubules of the T-system with Stretch Journal of Neuropathology and Experimental Neurology. Apr, 2011 | Pubmed ID: 21412170 Polymerase Transcriptase Release Factor (PTRF) Anchors MG53 Protein to Cell Injury Site for Initiation of Membrane Repair The Journal of Biological Chemistry. Apr, 2011 | Pubmed ID: 21343302 Junctophilin-2 Expression Silencing Causes Cardiocyte Hypertrophy and Abnormal Intracellular Calcium-handling Circulation. Heart Failure. Mar, 2011 | Pubmed ID: 21216834 Amphipathic Tail-anchoring Peptide and Bcl-2 Homology Domain-3 (BH3) Peptides from Bcl-2 Family Proteins Induce Apoptosis Through Different Mechanisms The Journal of Biological Chemistry. Mar, 2011 | Pubmed ID: 21189256 Increased Store-operated Ca2+ Entry in Skeletal Muscle with Reduced Calsequestrin-1 Expression Biophysical Journal. Sep, 2010 | Pubmed ID: 20816068 MG53 Constitutes a Primary Determinant of Cardiac Ischemic Preconditioning Circulation. Jun, 2010 | Pubmed ID: 20516375 Cardioprotection of Ischemia/reperfusion Injury by Cholesterol-dependent MG53-mediated Membrane Repair Circulation Research. Jul, 2010 | Pubmed ID: 20466981 Repression of Cardiac Phospholamban Gene Expression is Mediated by Thyroid Hormone Receptor-{alpha}1 and Involves Targeted Covalent Histone Modifications Endocrinology. Jun, 2010 | Pubmed ID: 20392835 S165F Mutation of Junctophilin 2 Affects Ca2+ Signalling in Skeletal Muscle The Biochemical Journal. Apr, 2010 | Pubmed ID: 20095964 Mitsugumin 53 (MG53) Facilitates Vesicle Trafficking in Striated Muscle to Contribute to Cell Membrane Repair Communicative & Integrative Biology. May, 2009 | Pubmed ID: 19641737 Membrane Repair Defects in Muscular Dystrophy Are Linked to Altered Interaction Between MG53, Caveolin-3, and Dysferlin The Journal of Biological Chemistry. Jun, 2009 | Pubmed ID: 19380584 The Amino-terminal Peptide of Bax Perturbs Intracellular Ca2+ Homeostasis to Enhance Apoptosis in Prostate Cancer Cells American Journal of Physiology. Cell Physiology. Feb, 2009 | Pubmed ID: 19091958 MG53 Nucleates Assembly of Cell Membrane Repair Machinery Nature Cell Biology. Jan, 2009 | Pubmed ID: 19043407 MG53 Regulates Membrane Budding and Exocytosis in Muscle Cells The Journal of Biological Chemistry. Jan, 2009 | Pubmed ID: 19029292 A Missense Mutation in Desmin Tail Domain Linked to Human Dilated Cardiomyopathy Promotes Cleavage of the Head Domain and Abolishes Its Z-disc Localization FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Sep, 2008 | Pubmed ID: 18539904 Compromised Store-operated Ca2+ Entry in Aged Skeletal Muscle Aging Cell. Aug, 2008 | Pubmed ID: 18505477 Caveolae/caveolin-1 Are Important Modulators of Store-operated Calcium Entry in Hs578/T Breast Cancer Cells Journal of Pharmacological Sciences. Feb, 2008 | Pubmed ID: 18296864 Altered Ca2+ Sparks in Aging Skeletal and Cardiac Muscle Ageing Research Reviews. Jul, 2008 | Pubmed ID: 18272434 Immuno-proteomic Approach to Excitation--contraction Coupling in Skeletal and Cardiac Muscle: Molecular Insights Revealed by the Mitsugumins Cell Calcium. Jan, 2008 | Pubmed ID: 18061662 The Tail-anchoring Domain of Bfl1 and HCCS1 Targets Mitochondrial Membrane Permeability to Induce Apoptosis Journal of Cell Science. Aug, 2007 | Pubmed ID: 17666431 TRIC Channels Are Essential for Ca2+ Handling in Intracellular Stores Nature. Jul, 2007 | Pubmed ID: 17611541 Mutations in JPH2-encoded Junctophilin-2 Associated with Hypertrophic Cardiomyopathy in Humans Journal of Molecular and Cellular Cardiology. Jun, 2007 | Pubmed ID: 17509612 Systemic Ablation of RyR3 Alters Ca2+ Spark Signaling in Adult Skeletal Muscle Cell Calcium. Dec, 2007 | Pubmed ID: 17412417 Azumolene Inhibits a Component of Store-operated Calcium Entry Coupled to the Skeletal Muscle Ryanodine Receptor The Journal of Biological Chemistry. Nov, 2006 | Pubmed ID: 16945924 Muscle Aging is Associated with Compromised Ca2+ Spark Signaling and Segregated Intracellular Ca2+ Release The Journal of Cell Biology. Aug, 2006 | Pubmed ID: 16943181 Ca2+ Sparks As a Plastic Signal for Skeletal Muscle Health, Aging, and Dystrophy Acta Pharmacologica Sinica. Jul, 2006 | Pubmed ID: 16787561 Uncoupling Store-operated Ca2+ Entry and Altered Ca2+ Release from Sarcoplasmic Reticulum Through Silencing of Junctophilin Genes Biophysical Journal. Jun, 2006 | Pubmed ID: 16565048 Enhanced Resistance to Fatigue and Altered Calcium Handling Properties of Sarcalumenin Knockout Mice Physiological Genomics. Sep, 2005 | Pubmed ID: 15998745 Uncontrolled Calcium Sparks Act As a Dystrophic Signal for Mammalian Skeletal Muscle Nature Cell Biology. May, 2005 | Pubmed ID: 15834406 Alterations in the Heart Mitochondrial Proteome in a Desmin Null Heart Failure Model Journal of Molecular and Cellular Cardiology. Mar, 2005 | Pubmed ID: 15733906 Structural and Functional Roles of Desmin in Mouse Skeletal Muscle During Passive Deformation Biophysical Journal. May, 2004 | Pubmed ID: 15111414 Cardiomyocyte-specific Desmin Rescue of Desmin Null Cardiomyopathy Excludes Vascular Involvement Journal of Molecular and Cellular Cardiology. Jan, 2004 | Pubmed ID: 14734054 Bcl-2 Overexpression Corrects Mitochondrial Defects and Ameliorates Inherited Desmin Null Cardiomyopathy Proceedings of the National Academy of Sciences of the United States of America. Jan, 2004 | Pubmed ID: 14715896 Een muizenmodel van myocard ischemie-reperfusie schade door de eileiders van de LAD Zhaobin Xu1, Jenna Alloush1, Eric Beck1, Noah Weisleder1 1Davis Heart & Lung Research Institute, Department of Physiology and Cell Biology, The Ohio State University JoVE 51329 의학 Beoordeling van Calcium Sparks in Intact Skeletal spiervezels Ki Ho Park1, Noah Weisleder2, Jingsong Zhou3, Kristyn Gumpper1, Xinyu Zhou1, Pu Duann4, Jianjie Ma1, Pei-Hui Lin1 1Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 2Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 3Department of Molecular Biophysics and Physiology, Rush University Medical Center, 4Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center JoVE 50898 생물학 Visualisatie van MG53-gemedieerde celmembraan Reparatie gebruik In vivo En In vitro Systemen Noah Weisleder1, Peihui Lin1, Xiaoli Zhao1, Matthew Orange1, Hua Zhu1, Jianjie Ma1 1Department of Physiology and Biophysics, Robert Wood Johnson Medical School JoVE 2717 생물학
Een muizenmodel van myocard ischemie-reperfusie schade door de eileiders van de LAD Zhaobin Xu1, Jenna Alloush1, Eric Beck1, Noah Weisleder1 1Davis Heart & Lung Research Institute, Department of Physiology and Cell Biology, The Ohio State University JoVE 51329 의학
Beoordeling van Calcium Sparks in Intact Skeletal spiervezels Ki Ho Park1, Noah Weisleder2, Jingsong Zhou3, Kristyn Gumpper1, Xinyu Zhou1, Pu Duann4, Jianjie Ma1, Pei-Hui Lin1 1Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 2Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 3Department of Molecular Biophysics and Physiology, Rush University Medical Center, 4Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center JoVE 50898 생물학
Visualisatie van MG53-gemedieerde celmembraan Reparatie gebruik In vivo En In vitro Systemen Noah Weisleder1, Peihui Lin1, Xiaoli Zhao1, Matthew Orange1, Hua Zhu1, Jianjie Ma1 1Department of Physiology and Biophysics, Robert Wood Johnson Medical School JoVE 2717 생물학