Timothy Billiar Department of Surgery University of Pittsburgh Biography Publications Institution JoVE Articles Timothy Billiar has not added a biography. If you are Timothy Billiar and would like to personalize this page please email our Author Liaison for assistance. Publications Changes in Massive Transfusion over Time: An Early Shift in the Right Direction? The Journal of Trauma. Jan, 2012 | Pubmed ID: 22310123 Evolving Role of Endovascular Techniques for Traumatic Vascular Injury: A Changing Landscape? The Journal of Trauma. Jan, 2012 | Pubmed ID: 22310114 Role of Macrophages in Mobilization of Hematopoietic Progenitor Cells From Bone Marrow After Hemorrhagic Shock Shock (Augusta, Ga.). Jan, 2012 | Pubmed ID: 22293600 Oral Intake of Hydrogen-rich Water Inhibits Intimal Hyperplasia in Arterialized Vein Grafts in Rats Cardiovascular Research. Jan, 2012 | Pubmed ID: 22287575 Splenocyte Apoptosis and Autophagy is Mediated by Interferon Regulatory Factor-1 During Murine Endotoxemia Shock (Augusta, Ga.). Jan, 2012 | Pubmed ID: 22266972 Complement C3 Deficiency Attenuates Chronic Hypoxia-induced Pulmonary Hypertension in Mice PloS One. 2011 | Pubmed ID: 22194859 A Genomic Storm in Critically Injured Humans The Journal of Experimental Medicine. Dec, 2011 | Pubmed ID: 22110166 Interferon Regulatory Factor-1 Regulates the Autophagic Response in LPS Stimulated Macrophages Through Nitric Oxide Molecular Medicine (Cambridge, Mass.). Nov, 2011 | Pubmed ID: 22105605 Assessment of Platelet Transfusion for Reversal of Aspirin After Traumatic Brain Injury Surgery. Oct, 2011 | Pubmed ID: 22000198 Hydrogen-enriched Preservation Protects the Isogeneic Intestinal Graft and Amends Recipient Gastric Function During Transplantation Transplantation. Nov, 2011 | Pubmed ID: 21956195 Hemorrhagic Shock Activation of NLRP3 Inflammasome in Lung Endothelial Cells Journal of Immunology (Baltimore, Md. : 1950). Nov, 2011 | Pubmed ID: 21940680 Mast Cells Play a Critical Role in the Systemic Inflammatory Response and End-organ Injury Resulting from Trauma Journal of the American College of Surgeons. Nov, 2011 | Pubmed ID: 21920785 Transcriptomic Response of Murine Liver to Severe Injury and Hemorrhagic Shock: a Dual-platform Microarray Analysis Physiological Genomics. Oct, 2011 | Pubmed ID: 21828244 Early Lower Extremity Fracture Fixation and the Risk of Early Pulmonary Embolus: Filter Before Fixation? The Journal of Trauma. Jun, 2011 | Pubmed ID: 21817975 The Effect of Donor Treatment with Hydrogen on Lung Allograft Function in Rats Surgery. Aug, 2011 | Pubmed ID: 21801961 Sepsis: Something Old, Something New, and a Systems View Journal of Critical Care. Jul, 2011 | Pubmed ID: 21798705 Characterization of DISC Formation and TNFR1 Translocation to Mitochondria in TNF-α-treated Hepatocytes The American Journal of Pathology. Sep, 2011 | Pubmed ID: 21741934 Endogenous Histones Function As Alarmins in Sterile Inflammatory Liver Injury Through Toll-like Receptor 9 in Mice Hepatology (Baltimore, Md.). Sep, 2011 | Pubmed ID: 21721026 Caspase-1 is Hepatoprotective During Trauma and Hemorrhagic Shock by Reducing Liver Injury and Inflammation Molecular Medicine (Cambridge, Mass.). Sep-Oct, 2011 | Pubmed ID: 21666957 High-mobility Group Box 1 is Essential for Mitochondrial Quality Control Cell Metabolism. Jun, 2011 | Pubmed ID: 21641551 A Dynamic View of Trauma/hemorrhage-induced Inflammation in Mice: Principal Drivers and Networks PloS One. 2011 | Pubmed ID: 21573002 Hypoxia-induced Overexpression of BNIP3 is Not Dependent on Hypoxia-inducible Factor 1α in Mouse Hepatocytes Shock (Augusta, Ga.). Aug, 2011 | Pubmed ID: 21558981 Hydrogen Inhalation Reduced Epithelial Apoptosis in Ventilator-induced Lung Injury Via a Mechanism Involving Nuclear Factor-kappa B Activation Biochemical and Biophysical Research Communications. May, 2011 | Pubmed ID: 21473852 Histidine-tryptophan-ketoglutarate or Celsior: Which is More Suitable for Cold Preservation for Cardiac Grafts from Older Donors? The Annals of Thoracic Surgery. Mar, 2011 | Pubmed ID: 21352993 Body Adipose Content is Independently Associated with a Higher Risk of Organ Failure and Nosocomial Infection in the Nonobese Patient Postinjury The Journal of Trauma. Feb, 2011 | Pubmed ID: 21307724 Over Reliance on Computed Tomography Imaging in Patients with Severe Abdominal Injury: is the Delay Worth the Risk? The Journal of Trauma. Feb, 2011 | Pubmed ID: 21307722 Models of Lower Extremity Damage in Mice: Time Course of Organ Damage and Immune Response The Journal of Surgical Research. Apr, 2011 | Pubmed ID: 21276982 DNA Attenuates Enterocyte Toll-like Receptor 4-mediated Intestinal Mucosal Injury After Remote Trauma American Journal of Physiology. Gastrointestinal and Liver Physiology. May, 2011 | Pubmed ID: 21233273 TNF/TNF Receptor 1-mediated Apoptosis in Hepatocytes Advances in Experimental Medicine and Biology. 2011 | Pubmed ID: 21153368 Interferon Regulatory Factor 1 Mediates Acetylation and Release of High Mobility Group Box 1 from Hepatocytes During Murine Liver Ischemia-reperfusion Injury Shock (Augusta, Ga.). Mar, 2011 | Pubmed ID: 20856174 Ex Vivo Carbon Monoxide Delivery Inhibits Intimal Hyperplasia in Arterialized Vein Grafts Cardiovascular Research. Feb, 2011 | Pubmed ID: 20851811 Hydrogen Therapy May Reduce the Risks Related to Radiation-induced Oxidative Stress in Space Flight Medical Hypotheses. Jan, 2011 | Pubmed ID: 20851533 Role of Hemorrhage in the Induction of Systemic Inflammation and Remote Organ Damage: Analysis of Combined Pseudo-fracture and Hemorrhagic Shock Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Feb, 2011 | Pubmed ID: 20690183 Systemic Inflammation and Liver Injury Following Hemorrhagic Shock and Peripheral Tissue Trauma Involve Functional TLR9 Signaling on Bone Marrow-derived Cells and Parenchymal Cells Shock (Augusta, Ga.). Feb, 2011 | Pubmed ID: 20577143 Hemorrhagic Shock Activates Lung Endothelial Reduced Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase Via Neutrophil NADPH Oxidase American Journal of Respiratory Cell and Molecular Biology. Mar, 2011 | Pubmed ID: 20418360 Toll-like Receptor Signaling in Liver Diseases Gastroenterology Research and Practice. 2010 | Pubmed ID: 21789039 Hydrogen Inhalation Ameliorates Ventilator-induced Lung Injury Critical Care (London, England). 2010 | Pubmed ID: 21184683 Inhaled Hydrogen Gas Therapy for Prevention of Lung Transplant-induced Ischemia/reperfusion Injury in Rats Transplantation. Dec, 2010 | Pubmed ID: 21048533 High Mobility Group Box 1 Release from Hepatocytes During Ischemia and Reperfusion Injury is Mediated by Decreased Histone Deacetylase Activity The Journal of Biological Chemistry. Dec, 2010 | Pubmed ID: 20937823 Differential Regulation by Fucoidan of IFN-γ-induced NO Production in Glial Cells and Macrophages Journal of Cellular Biochemistry. Dec, 2010 | Pubmed ID: 20830678 Toll-like Receptors in Hepatic Ischemia/reperfusion and Transplantation Gastroenterology Research and Practice. 2010 | Pubmed ID: 20811615 Incidental Radiographic Findings After Injury: Dedicated Attention Results in Improved Capture, Documentation, and Management Surgery. Oct, 2010 | Pubmed ID: 20705305 Complement Factor 3 Deficiency Attenuates Hemorrhagic Shock-related Hepatic Injury and Systemic Inflammatory Response Syndrome American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Nov, 2010 | Pubmed ID: 20702808 Superior Myocardial Preservation with HTK Solution over Celsior in Rat Hearts with Prolonged Cold Ischemia Surgery. Aug, 2010 | Pubmed ID: 20627336 A Critical Role for IFN Regulatory Factor 1 in NKT Cell-mediated Liver Injury Induced by Alpha-galactosylceramide Journal of Immunology (Baltimore, Md. : 1950). Aug, 2010 | Pubmed ID: 20624945 Hepatocytes Express Functional NOD1 and NOD2 Receptors: a Role for NOD1 in Hepatocyte CC and CXC Chemokine Production Journal of Hepatology. Oct, 2010 | Pubmed ID: 20615568 Delay to Therapeutic Interventional Radiology Postinjury: Time is of the Essence The Journal of Trauma. Jun, 2010 | Pubmed ID: 20539172 Dominant Role of the MyD88-dependent Signaling Pathway in Mediating Early Endotoxin-induced Murine Ileus American Journal of Physiology. Gastrointestinal and Liver Physiology. Aug, 2010 | Pubmed ID: 20508155 Analysis of Factorial Time-course Microarrays with Application to a Clinical Study of Burn Injury Proceedings of the National Academy of Sciences of the United States of America. Jun, 2010 | Pubmed ID: 20479259 Pivotal Advance: The Pattern Recognition Receptor Ligands Lipopolysaccharide and Polyinosine-polycytidylic Acid Stimulate Factor B Synthesis by the Macrophage Through Distinct but Overlapping Mechanisms Journal of Leukocyte Biology. Oct, 2010 | Pubmed ID: 20413727 Linking Oxidative Stress to Inflammation: Toll-like Receptors Free Radical Biology & Medicine. May, 2010 | Pubmed ID: 20083193 Amelioration of Rat Cardiac Cold Ischemia/reperfusion Injury with Inhaled Hydrogen or Carbon Monoxide, or Both The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. May, 2010 | Pubmed ID: 20036162 Nitric Oxide and Thioredoxin Type 1 Modulate the Activity of Caspase 8 in HepG2 Cells Biochemical and Biophysical Research Communications. Jan, 2010 | Pubmed ID: 20005201 Oral Hydrogen Water Prevents Chronic Allograft Nephropathy in Rats Kidney International. Jan, 2010 | Pubmed ID: 19907413 The Nitric Oxide Donor S-nitrosoglutathione Reduces Apoptotic Primary Liver Cell Loss in a Three-dimensional Perfusion Bioreactor Culture Model Developed for Liver Support Tissue Engineering. Part A. Mar, 2010 | Pubmed ID: 19814591 Toll-like Receptors and Myocardial Ischemia/reperfusion, Inflammation, and Injury Current Cardiology Reviews. Aug, 2009 | Pubmed ID: 20676278 An Adequately Robust Early TNF-alpha Response is a Hallmark of Survival Following Trauma/hemorrhage PloS One. 2009 | Pubmed ID: 20027315 Hemorrhagic Shock Augments Lung Endothelial Cell Activation: Role of Temporal Alterations of TLR4 and TLR2 American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Dec, 2009 | Pubmed ID: 19828841 Nitric Oxide and Dihydrolipoic Acid Modulate the Activity of Caspase 3 in HepG2 Cells FEBS Letters. Nov, 2009 | Pubmed ID: 19822150 Preinjury Statin Use is Associated with a Higher Risk of Multiple Organ Failure After Injury: a Propensity Score Adjusted Analysis The Journal of Trauma. Sep, 2009 | Pubmed ID: 19741387 Fresh Frozen Plasma is Independently Associated with a Higher Risk of Multiple Organ Failure and Acute Respiratory Distress Syndrome The Journal of Trauma. Aug, 2009 | Pubmed ID: 19667872 Orally Administered Nitrite Attenuates Cardiac Allograft Rejection in Rats Surgery. Aug, 2009 | Pubmed ID: 19628069 Activation of Latent Transforming Growth Factor-beta1 by Nitric Oxide in Macrophages: Role of Soluble Guanylate Cyclase and MAP Kinases Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. Jul-Aug, 2009 | Pubmed ID: 19614923 Preactivation of NKT Cells with Alpha-GalCer Protects Against Hepatic Ischemia-reperfusion Injury in Mouse by a Mechanism Involving IL-13 and Adenosine A2A Receptor American Journal of Physiology. Gastrointestinal and Liver Physiology. Aug, 2009 | Pubmed ID: 19556359 Cisplatin Prevents High Mobility Group Box 1 Release and is Protective in a Murine Model of Hepatic Ischemia/reperfusion Injury Hepatology (Baltimore, Md.). Aug, 2009 | Pubmed ID: 19492424 Low-dose Cisplatin Administration in Murine Cecal Ligation and Puncture Prevents the Systemic Release of HMGB1 and Attenuates Lethality Journal of Leukocyte Biology. Sep, 2009 | Pubmed ID: 19487305 Innate Immune Mechanisms in Ischemia/reperfusion Frontiers in Bioscience (Elite Edition). 2009 | Pubmed ID: 19482628 Mechanisms of Toll-like Receptor 4 (TLR4)-mediated Inflammation After Cold Ischemia/reperfusion in the Heart Transplantation. May, 2009 | Pubmed ID: 19461481 Endotoxin Uptake in Mouse Liver is Blocked by Endotoxin Pretreatment Through a Suppressor of Cytokine Signaling-1-dependent Mechanism Hepatology (Baltimore, Md.). May, 2009 | Pubmed ID: 19296467 Possible Novel Therapy for Malignant Gliomas with Secretable Trimeric TRAIL PloS One. 2009 | Pubmed ID: 19229339 Therapeutic Antioxidant Medical Gas Journal of Clinical Biochemistry and Nutrition. Jan, 2009 | Pubmed ID: 19177183 Expression and Subcellular Localization of BNIP3 in Hypoxic Hepatocytes and Liver Stress American Journal of Physiology. Gastrointestinal and Liver Physiology. Mar, 2009 | Pubmed ID: 19147804 Studies Toward the Analysis of S-nitrosoproteins Organic & Biomolecular Chemistry. Jan, 2009 | Pubmed ID: 19109666 Interacting Neuroendocrine and Innate and Acquired Immune Pathways Regulate Neutrophil Mobilization from Bone Marrow Following Hemorrhagic Shock Journal of Immunology (Baltimore, Md. : 1950). Jan, 2009 | Pubmed ID: 19109190 An FFP:PRBC Transfusion Ratio >/=1:1.5 is Associated with a Lower Risk of Mortality After Massive Transfusion The Journal of Trauma. Nov, 2008 | Pubmed ID: 19001962 Parenteral Calcium for Intensive Care Unit Patients Cochrane Database of Systematic Reviews (Online). 2008 | Pubmed ID: 18843706 Calcium/calmodulin-dependent Protein Kinase (CaMK) IV Mediates Nucleocytoplasmic Shuttling and Release of HMGB1 During Lipopolysaccharide Stimulation of Macrophages Journal of Immunology (Baltimore, Md. : 1950). Oct, 2008 | Pubmed ID: 18802105 Beta2-integrin-induced P38 MAPK Activation is a Key Mediator in the CD14/TLR4/MD2-dependent Uptake of Lipopolysaccharide by Hepatocytes The Journal of Biological Chemistry. Oct, 2008 | Pubmed ID: 18701460 Preconditioning with High Mobility Group Box 1 (HMGB1) Induces Lipopolysaccharide (LPS) Tolerance Journal of Leukocyte Biology. Nov, 2008 | Pubmed ID: 18687905 The Role of Fracture-associated Soft Tissue Injury in the Induction of Systemic Inflammation and Remote Organ Dysfunction After Bilateral Femur Fracture Journal of Orthopaedic Trauma. Jul, 2008 | Pubmed ID: 18594302 Patterns of Cytokine Release and Evolution of Remote Organ Dysfunction After Bilateral Femur Fracture Shock (Augusta, Ga.). Jul, 2008 | Pubmed ID: 18562923 Detection and Measurement for the Modification and Inactivation of Caspase by Nitrosative Stress in Vitro and in Vivo Methods in Enzymology. 2008 | Pubmed ID: 18554542 Changes in FADD Levels, Distribution, and Phosphorylation in TNFalpha-induced Apoptosis in Hepatocytes is Caspase-3, Caspase-8 and BID Dependent Apoptosis : an International Journal on Programmed Cell Death. Aug, 2008 | Pubmed ID: 18543108 Computational Insights on the Competing Effects of Nitric Oxide in Regulating Apoptosis PloS One. 2008 | Pubmed ID: 18509469 Carbon Monoxide Activates NF-kappaB Via ROS Generation and Akt Pathways to Protect Against Cell Death of Hepatocytes American Journal of Physiology. Gastrointestinal and Liver Physiology. Jul, 2008 | Pubmed ID: 18497334 Local Exposure of Bone Components to Injured Soft Tissue Induces Toll-like Receptor 4-dependent Systemic Inflammation with Acute Lung Injury Shock (Augusta, Ga.). Dec, 2008 | Pubmed ID: 18461022 HMGB1: Endogenous Danger Signaling Molecular Medicine (Cambridge, Mass.). Jul-Aug, 2008 | Pubmed ID: 18431461 Application of Heme Oxygenase-1, Carbon Monoxide and Biliverdin for the Prevention of Intestinal Ischemia/reperfusion Injury Journal of Clinical Biochemistry and Nutrition. Mar, 2008 | Pubmed ID: 18385824 Male Gender is Associated with Excessive IL-6 Expression Following Severe Injury The Journal of Trauma. Mar, 2008 | Pubmed ID: 18332795 Protective Effect of P53 in Vascular Smooth Muscle Cells Against Nitric Oxide-induced Apoptosis is Mediated by Up-regulation of Heme Oxygenase-2 BMB Reports. Feb, 2008 | Pubmed ID: 18315954 Carbon Monoxide Decreases the Level of INOS Protein and Active Dimer in IL-1beta-stimulated Hepatocytes Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. Jun, 2008 | Pubmed ID: 18313411 Galantamine and Carbon Monoxide Protect Brain Microvascular Endothelial Cells by Heme Oxygenase-1 Induction Biochemical and Biophysical Research Communications. Mar, 2008 | Pubmed ID: 18174021 Early Events in the Recognition of Danger Signals After Tissue Injury Journal of Leukocyte Biology. Mar, 2008 | Pubmed ID: 18032691 FXR-mediated Regulation of Angiotensin Type 2 Receptor Expression in Vascular Smooth Muscle Cells Cardiovascular Research. Feb, 2008 | Pubmed ID: 18006431 Systemic Inflammation and End Organ Damage Following Trauma Involves Functional TLR4 Signaling in Both Bone Marrow-derived Cells and Parenchymal Cells Journal of Leukocyte Biology. Jan, 2008 | Pubmed ID: 17925504 Toll-like Receptor 4 Mediates the Early Inflammatory Response After Cold Ischemia/reperfusion Transplantation. Nov, 2007 | Pubmed ID: 18049113 HMGB1 Release Induced by Liver Ischemia Involves Toll-like Receptor 4 Dependent Reactive Oxygen Species Production and Calcium-mediated Signaling The Journal of Experimental Medicine. Nov, 2007 | Pubmed ID: 17984303 The Grateful Dead: Damage-associated Molecular Pattern Molecules and Reduction/oxidation Regulate Immunity Immunological Reviews. Dec, 2007 | Pubmed ID: 17979840 Increased Interactive Format for Morbidity & Mortality Conference Improves Educational Value and Enhances Confidence Journal of Surgical Education. Sep-Oct, 2007 | Pubmed ID: 17961883 Systemic Inflammation and Remote Organ Injury Following Trauma Require HMGB1 American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Oct, 2007 | Pubmed ID: 17652366 Thioredoxin Catalyzes the Denitrosation of Low-molecular Mass and Protein S-nitrosothiols Biochemistry. Jul, 2007 | Pubmed ID: 17580965 Hypoxia Activates C-Jun N-terminal Kinase Via Rac1-dependent Reactive Oxygen Species Production in Hepatocytes Shock (Augusta, Ga.). Sep, 2007 | Pubmed ID: 17545941 Neutrophil NAD(P)H Oxidase is Required for Hemorrhagic Shock-enhanced TLR2 Up-regulation in Alveolar Macrophages in Response to LPS Shock (Augusta, Ga.). Aug, 2007 | Pubmed ID: 17515854 Masquerader: High Mobility Group Box-1 and Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2007 | Pubmed ID: 17504981 Hemorrhagic Shock Induces NAD(P)H Oxidase Activation in Neutrophils: Role of HMGB1-TLR4 Signaling Journal of Immunology (Baltimore, Md. : 1950). May, 2007 | Pubmed ID: 17475888 A Novel Inhibitory Peptide of Toll-like Receptor Signaling Limits Lipopolysaccharide-induced Production of Inflammatory Mediators and Enhances Survival in Mice Shock (Augusta, Ga.). Apr, 2007 | Pubmed ID: 17414417 Neuronal NOS-mediated Nitration and Inactivation of Manganese Superoxide Dismutase in Brain After Experimental and Human Brain Injury Journal of Neurochemistry. Apr, 2007 | Pubmed ID: 17394464 Making Progress in an Enlightened Era: Opportunities and Obstacles Surgical Infections. Feb, 2007 | Pubmed ID: 17381393 Targeting CD47: NO Limit on Therapeutic Potential Circulation Research. Mar, 2007 | Pubmed ID: 17363705 Carbon Monoxide Signals Via Inhibition of Cytochrome C Oxidase and Generation of Mitochondrial Reactive Oxygen Species FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Apr, 2007 | Pubmed ID: 17264172 Early Growth Response 1 Mediates the Systemic and Hepatic Inflammatory Response Initiated by Hemorrhagic Shock Shock (Augusta, Ga.). Feb, 2007 | Pubmed ID: 17224790 Increasing Numbers of Hepatic Dendritic Cells Promote HMGB1-mediated Ischemia-reperfusion Injury Journal of Leukocyte Biology. Jan, 2007 | Pubmed ID: 17062605 The Role of Initial Trauma in the Host's Response to Injury and Hemorrhage: Insights from a Correlation of Mathematical Simulations and Hepatic Transcriptomic Analysis Shock (Augusta, Ga.). Dec, 2006 | Pubmed ID: 17117135 Emerging Paradigm: Toll-like Receptor 4-sentinel for the Detection of Tissue Damage Shock (Augusta, Ga.). Nov, 2006 | Pubmed ID: 17047512 In Silico and in Vivo Approach to Elucidate the Inflammatory Complexity of CD14-deficient Mice Molecular Medicine (Cambridge, Mass.). Apr-Jun, 2006 | Pubmed ID: 16953560 Anti-HMGB1 Neutralizing Antibody Ameliorates Gut Barrier Dysfunction and Improves Survival After Hemorrhagic Shock Molecular Medicine (Cambridge, Mass.). Apr-Jun, 2006 | Pubmed ID: 16953558 Ischemic Preconditioning of the Murine Liver Protects Through the Akt Kinase Pathway Hepatology (Baltimore, Md.). Sep, 2006 | Pubmed ID: 16941697 In Silico Models of Acute Inflammation in Animals Shock (Augusta, Ga.). Sep, 2006 | Pubmed ID: 16912648 Carbon Monoxide Reverses Established Pulmonary Hypertension The Journal of Experimental Medicine. Sep, 2006 | Pubmed ID: 16908624 Low-dose Carbon Monoxide Inhalation Prevents Ischemia/reperfusion Injury of Transplanted Rat Lung Grafts Surgery. Aug, 2006 | Pubmed ID: 16904967 Leukocyte-derived Inducible Nitric Oxide Synthase Mediates Murine Postoperative Ileus Annals of Surgery. Aug, 2006 | Pubmed ID: 16858184 Cutting Edge: High-mobility Group Box 1 Preconditioning Protects Against Liver Ischemia-reperfusion Injury Journal of Immunology (Baltimore, Md. : 1950). Jun, 2006 | Pubmed ID: 16751357 The Role of RAGE in the Pathogenesis of Intestinal Barrier Dysfunction After Hemorrhagic Shock American Journal of Physiology. Gastrointestinal and Liver Physiology. Oct, 2006 | Pubmed ID: 16751175 Systemic Inflammation and Remote Organ Damage Following Bilateral Femur Fracture Requires Toll-like Receptor 4 American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Oct, 2006 | Pubmed ID: 16675630 Carbon Monoxide Protects Hepatocytes from TNF-alpha/Actinomycin D by Inhibition of the Caspase-8-mediated Apoptotic Pathway Biochemical and Biophysical Research Communications. Jun, 2006 | Pubmed ID: 16647044 Toll-like Receptor-4 Signaling Mediates Hepatic Injury and Systemic Inflammation in Hemorrhagic Shock Journal of the American College of Surgeons. Mar, 2006 | Pubmed ID: 16500244 Enterocyte TLR4 Mediates Phagocytosis and Translocation of Bacteria Across the Intestinal Barrier Journal of Immunology (Baltimore, Md. : 1950). Mar, 2006 | Pubmed ID: 16493066 Hemorrhagic Shock-activated Neutrophils Augment TLR4 Signaling-induced TLR2 Upregulation in Alveolar Macrophages: Role in Hemorrhage-primed Lung Inflammation American Journal of Physiology. Lung Cellular and Molecular Physiology. Apr, 2006 | Pubmed ID: 16272176 Nitric Oxide: a Clinical Primer Critical Care Medicine. Dec, 2005 | Pubmed ID: 16340431 Hepatic Ischemia/reperfusion Injury Involves Functional TLR4 Signaling in Nonparenchymal Cells Journal of Immunology (Baltimore, Md. : 1950). Dec, 2005 | Pubmed ID: 16301676 Thioredoxin and Lipoic Acid Catalyze the Denitrosation of Low Molecular Weight and Protein S-nitrosothiols Journal of the American Chemical Society. Nov, 2005 | Pubmed ID: 16277524 Glutathione Depletion Renders Rat Hepatocytes Sensitive to Nitric Oxide Donor-mediated Toxicity Hepatology (Baltimore, Md.). Sep, 2005 | Pubmed ID: 16116630 Biliverdin Administration Prevents the Formation of Intimal Hyperplasia Induced by Vascular Injury Circulation. Jul, 2005 | Pubmed ID: 16027253 The Role of Hepatic Type 1 Plasminogen Activator Inhibitor (PAI-1) During Murine Hemorrhagic Shock Hepatology (Baltimore, Md.). Aug, 2005 | Pubmed ID: 16025510 The Acute Inflammatory Response in Diverse Shock States Shock (Augusta, Ga.). Jul, 2005 | Pubmed ID: 15988324 Carbon Monoxide Prevents Multiple Organ Injury in a Model of Hemorrhagic Shock and Resuscitation Shock (Augusta, Ga.). Jun, 2005 | Pubmed ID: 15897805 Hepatocytes Enhance Effects of Lipopolysaccharide on Liver Nonparenchymal Cells Through Close Cell Interactions Shock (Augusta, Ga.). May, 2005 | Pubmed ID: 15834312 Induction of IL-6 Within the Rodent Intestinal Muscularis After Intestinal Surgical Stress Surgery. Apr, 2005 | Pubmed ID: 15800492 The Nuclear Factor HMGB1 Mediates Hepatic Injury After Murine Liver Ischemia-reperfusion The Journal of Experimental Medicine. Apr, 2005 | Pubmed ID: 15795240 Application of Genome-wide Expression Analysis to Human Health and Disease Proceedings of the National Academy of Sciences of the United States of America. Mar, 2005 | Pubmed ID: 15781863 Enhanced Oxidative Stress in INOS-deficient Mice After Traumatic Brain Injury: Support for a Neuroprotective Role of INOS Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Jun, 2005 | Pubmed ID: 15716856 Protection Against Ischemia/reperfusion Injury in Cardiac and Renal Transplantation with Carbon Monoxide, Biliverdin and Both American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Feb, 2005 | Pubmed ID: 15643987 Inflammatory Modulation of Hepatocyte Apoptosis by Nitric Oxide: in Vivo, in Vitro, and in Silico Studies Current Molecular Medicine. Nov, 2004 | Pubmed ID: 15579022 Nitric Oxide and Ionizing Radiation Synergistically Promote Apoptosis and Growth Inhibition of Cancer by Activating P53 Cancer Research. Nov, 2004 | Pubmed ID: 15520210 IFN-gamma Enhances TRAIL-induced Apoptosis Through IRF-1 European Journal of Biochemistry / FEBS. Nov, 2004 | Pubmed ID: 15511228 Tissue Hypoxia Activates JNK in the Liver During Hemorrhagic Shock Shock (Augusta, Ga.). Oct, 2004 | Pubmed ID: 15377896 Nitric Oxide Suppresses Inducible Nitric Oxide Synthase Expression by Inhibiting Post-translational Modification of IkappaB Experimental & Molecular Medicine. Aug, 2004 | Pubmed ID: 15365250 The Secretable Form of Trimeric TRAIL, a Potent Inducer of Apoptosis Biochemical and Biophysical Research Communications. Sep, 2004 | Pubmed ID: 15358116 Nitric Oxide Facilitates Cardiomyogenesis in Mouse Embryonic Stem Cells Proceedings of the National Academy of Sciences of the United States of America. Aug, 2004 | Pubmed ID: 15304656 Hypoxia Inhibits Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis by Blocking Bax Translocation Cancer Research. Jun, 2004 | Pubmed ID: 15205314 The Department of Surgery at the School of Medicine at the University Of Pittsburgh, Pittsburgh, Pa Archives of Surgery (Chicago, Ill. : 1960). May, 2004 | Pubmed ID: 15136344 'Til Cell Death Do Us Part: Nitric Oxide and Mechanisms of Hepatotoxicity Biological Chemistry. Jan, 2004 | Pubmed ID: 14977041 Adenoviral Gene Transfer of the Human Inducible Nitric Oxide Synthase Gene Enhances the Radiation Response of Human Colorectal Cancer Associated with Alterations in Tumor Vascularity Cancer Research. Feb, 2004 | Pubmed ID: 14973054 Blood Soluble Drag-reducing Polymers Prevent Lethality from Hemorrhagic Shock in Acute Animal Experiments Biorheology. 2004 | Pubmed ID: 14967890 IRF-1 Expression Induces Apoptosis and Inhibits Tumor Growth in Mouse Mammary Cancer Cells in Vitro and in Vivo Oncogene. Feb, 2004 | Pubmed ID: 14762441 Induced Nitric Oxide Promotes Intestinal Inflammation Following Hemorrhagic Shock American Journal of Physiology. Gastrointestinal and Liver Physiology. Feb, 2004 | Pubmed ID: 14715517 Carbon Monoxide Inhibits T Lymphocyte Proliferation Via Caspase-dependent Pathway Journal of Immunology (Baltimore, Md. : 1950). Jan, 2004 | Pubmed ID: 14707100 Selective Jejunal Manipulation Causes Postoperative Pan-enteric Inflammation and Dysmotility Gastroenterology. Jan, 2004 | Pubmed ID: 14699497 Carbon Monoxide Protects Against Liver Failure Through Nitric Oxide-induced Heme Oxygenase 1 The Journal of Experimental Medicine. Dec, 2003 | Pubmed ID: 14657222 Role of Nitric Oxide in Liver Injury Current Molecular Medicine. Sep, 2003 | Pubmed ID: 14527083 A Role for Angiotensin II in the Activation of Extracellular Signal-regulated Kinases in the Liver During Hemorrhagic Shock Shock (Augusta, Ga.). Oct, 2003 | Pubmed ID: 14501944 Nitric Oxide-mediated Inhibition of Caspase-dependent T Lymphocyte Proliferation Journal of Leukocyte Biology. Sep, 2003 | Pubmed ID: 12949244 RhoA Influences the Nuclear Localization of Extracellular Signal-regulated Kinases to Modulate P21Waf/Cip1 Expression Circulation. Aug, 2003 | Pubmed ID: 12874183 Fas-associating Death Domain Protein Overexpression Induces Apoptosis in Lung Cancer Cells The Journal of Thoracic and Cardiovascular Surgery. Jun, 2003 | Pubmed ID: 12830053 Nitric Oxide and Wound Repair The Surgical Clinics of North America. Jun, 2003 | Pubmed ID: 12822723 Nitric Oxide Prevents 6-hydroxydopamine-induced Apoptosis in PC12 Cells Through CGMP-dependent PI3 Kinase/Akt Activation FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2003 | Pubmed ID: 12773486 There's NO Business Like P53 Business: Nitric Oxide Regulates Phosphorylation of P53 in Chronic Inflammatory Disease Cell Cycle (Georgetown, Tex.). Mar-Apr, 2003 | Pubmed ID: 12695658 Autologous Nitric Oxide Protects Mouse and Human Keratinocytes from Ultraviolet B Radiation-induced Apoptosis American Journal of Physiology. Cell Physiology. May, 2003 | Pubmed ID: 12676653 Heme Oxygenase-1: a Cellular Hercules Hepatology (Baltimore, Md.). Apr, 2003 | Pubmed ID: 12668964 Overexpression of the Human Inducible Nitric Oxide Synthase Gene Enhances Radiation-induced Apoptosis in Colorectal Cancer Cells Via a Caspase-dependent Mechanism Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. Mar, 2003 | Pubmed ID: 12620375 Regulation of Tissue Factor Expression in Smooth Muscle Cells with Nitric Oxide Journal of Vascular Surgery : Official Publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter. Mar, 2003 | Pubmed ID: 12618706 Intra-abdominal Activation of a Local Inflammatory Response Within the Human Muscularis Externa During Laparotomy Annals of Surgery. Mar, 2003 | Pubmed ID: 12616113 Ultraviolet Irradiation Increases FADD Protein in Apoptotic Human Keratinocytes Biochemical and Biophysical Research Communications. Mar, 2003 | Pubmed ID: 12604344 Characterization of the Expression of Inducible Nitric Oxide Synthase in Rat and Human Liver During Hemorrhagic Shock Shock (Augusta, Ga.). Feb, 2003 | Pubmed ID: 12578118 Carbon Monoxide Suppresses Arteriosclerotic Lesions Associated with Chronic Graft Rejection and with Balloon Injury Nature Medicine. Feb, 2003 | Pubmed ID: 12539038 Maternity Policy and Practice During Surgery Residency: How We Do It Surgery. Oct, 2002 | Pubmed ID: 12407353 A DNA Microarray Study of Nitric Oxide-induced Genes in Mouse Hepatocytes: Implications for Hepatic Heme Oxygenase-1 Expression in Ischemia/reperfusion Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. Nov, 2002 | Pubmed ID: 12381414 Nitric Oxide (NO) Pretreatment Increases Cytokine-induced NO Production in Cultured Rat Hepatocytes by Suppressing GTP Cyclohydrolase I Feedback Inhibitory Protein Level and Promoting Inducible NO Synthase Dimerization The Journal of Biological Chemistry. Dec, 2002 | Pubmed ID: 12359727 Nitric Oxide and Wound Repair: Role of Cytokines? Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. Aug, 2002 | Pubmed ID: 12175813 A Brief Episode of Hypotension Increases Mortality in Critically Ill Trauma Patients The Journal of Trauma. Aug, 2002 | Pubmed ID: 12169927 Hepatocyte Fas-associating Death Domain Protein/mediator of Receptor-induced Toxicity (FADD/MORT1) Levels Increase in Response to Pro-apoptotic Stimuli The Journal of Biological Chemistry. Oct, 2002 | Pubmed ID: 12167637 Peroxisomal Localization of Inducible Nitric Oxide Synthase in Hepatocytes Hepatology (Baltimore, Md.). Jul, 2002 | Pubmed ID: 12085352 Mechanisms of Hepatoprotection by Nitric Oxide Annals of the New York Academy of Sciences. May, 2002 | Pubmed ID: 12076992 Role of Toll-like Receptors in Changes in Gene Expression and NF-kappa B Activation in Mouse Hepatocytes Stimulated with Lipopolysaccharide Infection and Immunity. Jul, 2002 | Pubmed ID: 12065483 Signaling and Function of Caspase and C-jun N-terminal Kinase in Cisplatin-induced Apoptosis Molecules and Cells. Apr, 2002 | Pubmed ID: 12018840 Requirements for NF-kappaB Activation in Hemorrhagic Shock Archives of Orthopaedic and Trauma Surgery. Feb, 2002 | Pubmed ID: 11995880 Inducible Nitric Oxide Synthase: from Cloning to Therapeutic Applications World Journal of Surgery. Jul, 2002 | Pubmed ID: 11960209 Role of Galectin-3 in Breast Cancer Metastasis: Involvement of Nitric Oxide The American Journal of Pathology. Mar, 2002 | Pubmed ID: 11891203 IFN-gamma Inhibition of TRAIL-induced IAP-2 Upregulation, a Possible Mechanism of IFN-gamma-enhanced TRAIL-induced Apoptosis Biochemical and Biophysical Research Communications. Feb, 2002 | Pubmed ID: 11846395 A Nitric Oxide Scavenger Protects Against Pulmonary Inflammation Following Hemorrhagic Shock Shock (Augusta, Ga.). Feb, 2002 | Pubmed ID: 11837796 TRISS Unexpected Survivors: an Outdated Standard? The Journal of Trauma. Feb, 2002 | Pubmed ID: 11834980 Potentiation of Nitric Oxide-induced Apoptosis in P53-/- Vascular Smooth Muscle Cells American Journal of Physiology. Cell Physiology. Mar, 2002 | Pubmed ID: 11832348 Hypoxia Inhibition of Apoptosis Induced by Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Biochemical and Biophysical Research Communications. Feb, 2002 | Pubmed ID: 11829475 The Modulation of Hepatic Injury and Heat Shock Expression by Inhibition of Inducible Nitric Oxide Synthase After Hemorrhagic Shock Shock (Augusta, Ga.). Jan, 2002 | Pubmed ID: 11795663 Pseudofracture: An Acute Peripheral Tissue Trauma Model Sophie S. Darwiche1, Philipp Kobbe2, Roman Pfeifer2, Lauryn Kohut1, Hans-Christoph Pape2, Timothy Billiar1 1Department of Surgery, University of Pittsburgh, 2Department of Orthopedic Surgery, University of Aachen Medical Center JoVE 2074 의학
Pseudofracture: An Acute Peripheral Tissue Trauma Model Sophie S. Darwiche1, Philipp Kobbe2, Roman Pfeifer2, Lauryn Kohut1, Hans-Christoph Pape2, Timothy Billiar1 1Department of Surgery, University of Pittsburgh, 2Department of Orthopedic Surgery, University of Aachen Medical Center JoVE 2074 의학