Waiting
로그인 처리 중...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Medicine / Cell Death Associated with Abnormal Mitosis…
JoVE Journal
Medicine

JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다. 전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.

JoVE Journal Medicine
Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells
 

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells

Article DOI: 10.3791/50568-v • 15:53 min • August 21st, 2013
August 21st, 2013 •
1, 2,3, 4, 4, 5, 1,6, 2,3
1Cancer Research Center, Sheba Medical Center, 2The Neufeld Cardiac Research Institute, Tel-Aviv University, 3Department of Physiology and Pharmacology, Tel-Aviv University, 4Imaging Unit, Sackler Faculty of Medicine, Tel-Aviv University, 5Biotechnology and Cell Signaling, Ecole Superieure de Biotechnologie Strasbourg, 6Department of Human Molecular Genetics and Biochemistry, Tel-Aviv University

챕터

요약
Automatic Translation

The cytotoxic activity of the phenanthridine PJ-34 in cancer cells undergoing mitosis was documented in real time by live confocal imaging. PJ-34 eradicated human breast cancer MDA-MB-231 cells harboring extra-centrosomes in mitosis. Unlike normal bi-focal mitosis, the extra-centrosomes were not clustered in the two spindle poles in the presence of PJ-34.

Tags

Cell Death Abnormal Mitosis Confocal Imaging Live Cancer Cells PARP1 Inhibitors Phenanthrene Derivatives Supernumerary Centrosomes Multi-centrosomal Cells Solid Human Cancers PJ-34 Real-time Imaging Breast Cancer MDA-MB-231 Cells Fluorescent γ-tubulin Fluorescent Histone H2b Aberrant Chromosome Arrangements Declustered Centrosomes Spindle Poles Cytotoxic Activity
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter