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Journal / Bioengineering / CometChip: A High-throughput 96-Well Platform for …
JoVE Journal
Bioengineering

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CometChip: A High-throughput 96-Well Platform for Measuring DNA Damage in Microarrayed Human Cells

Article DOI: 10.3791/50607-v • 10:59 min • October 18th, 2014
October 18th, 2014 •
*1, *2, 3, 1, 1, 2, 2, 1
1Department of Biological Engineering, Massachusetts Institute of Technology, 2Environmental Toxicology, Chulabhorn Graduate Institute, 3Department of Biomedical Engineering, University of Minnesota
* These authors contributed equally

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요약
Automatic Translation

We describe here a platform that allows comet assay detection of DNA damage with unprecedented throughput. The device patterns mammalian cells into a microarray and enables parallel processing of 96 samples. The approach facilitates analysis of base level DNA damage, exposure-induced DNA damage and DNA repair kinetics.

Tags

DNA Damage Comet Assay CometChip High-throughput 96-well Platform Microarray DNA Damaging Agents Genotoxicity Testing Drug Development Epidemiological Studies Clinical Assays
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