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Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
 

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Article DOI: 10.3791/52200-v • 10:08 min • December 2nd, 2014
December 2nd, 2014 •
1, 2, 3, 2, 1, 4, 4, 1,2, 1,2
1Department of Biomedical Engineering, Johns Hopkins University, 2Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, 3Department of Medicine (Cardiology), Johns Hopkins University, 4The Australian School of Advanced Medicine, Macquarie University

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요약
Automatic Translation

We describe a technique for measuring aortic stiffness from its pressure-diameter relationship in vivo in mice. Aortic diameter is recorded by ultrasound and aortic pressure is measured invasively with a solid-state pressure catheter. Blood pressure is changed incrementally and the resulting diameter is measured.

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Keywords: Aortic Stiffness In Vivo Mice Ultrasound Pressure-diameter Relationship Arterial Compliance Cardiovascular Disease Aging Vasoactive Drugs Phenylephrine Sodium Nitroprusside Aortic Diameter Aortic Blood Pressure
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