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Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
 

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Article DOI: 10.3791/52665-v • 10:04 min • May 1st, 2015
May 1st, 2015 •
*1,4, *1,2, 1, 1,3
1Department of Internal Medicine V, Innsbruck Medical University, 2Oncotyrol GmbH, 3Tyrolean Cancer Research Institute, 4Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute
* These authors contributed equally

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요약
Automatic Translation

Human multiple myeloma (MM) cells require the supportive microenvironment of mesenchymal cells and extracellular matrix components for survival and proliferation. We established an in vivo chicken embryo model with engrafted human myeloma and mesenchymal cells to study effects of cancer drugs on tumor growth, invasion and angiogenesis.

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Keywords: Multiple Myeloma Xenograft Model Chicken Chorioallantoic Membrane 3D Culture Angiogenesis Tumor Growth Invasion GFP Reporter Mesenchymal Cells Collagen RPMI-8226 OPM-2 Therapeutic Screening
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