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Lavage-induced Surfactant Depletion in Pigs As a Model of the Acute Respiratory Distress Syndrome (ARDS)
 

Lavage-induced Surfactant Depletion in Pigs As a Model of the Acute Respiratory Distress Syndrome (ARDS)

Article DOI: 10.3791/53610-v • 07:20 min • September 7th, 2016
September 7th, 2016 •
1, 1, 1, 2, *1, *1
1Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité - Universitätsmedizin, Berlin, 2Department of Anesthesiology and Intensive Care Medicine, University of Leipzig Medical Faculty
* These authors contributed equally

챕터

요약
Automatic Translation

Repeated pulmonary lavages in anesthetized pigs induce lung injury resembling major aspects of human acute respiratory distress syndrome (ARDS). For this purpose the lungs are repeatedly lavaged with 0.9% saline at 37 °C. The goal of the protocol is a reproducible mitigation of gas exchange and hemodynamics for research in ARDS.

Tags

Keywords: ARDS Model Surfactant Depletion Lung Injury Pigs Mechanical Ventilation Pulmonary Artery Catheter Central Venous Line Arterial Catheter Pressure Monitoring
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