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Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors
 

Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors

Article DOI: 10.3791/54226-v • 09:01 min • August 18th, 2016
August 18th, 2016 •
1,2,3, 2, 3,4, 2,4,5, 1,2,3,4,5,6
1Department of Medical Biophysics, University of Toronto, 2Leslie Dan Faculty of Pharmacy, University of Toronto, 3STTARR Innovation Centre, Princess Margaret Cancer Centre, 4Institute of Biomaterials and Biomedical Engineering, University of Toronto, 5Techna Institute, University Health Network, 6Radiation Medicine Program, Princess Margaret Cancer Centre

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요약
Automatic Translation

The heterogeneous intra-tumoral accumulation of liposomes has been linked to an abnormal tumor microenvironment. Herein methods are presented to measure tumor microcirculation by perfusion imaging and elevated interstitial fluid pressure (IFP) using an image-guided robotic system. Measurements are compared to the intra-tumoral accumulation of liposomes, determined using volumetric micro-CT imaging.

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Keywords: Tumor Microenvironment Nanotherapeutics Nanoparticle Distribution Tumor Microcirculation Interstitial Fluid Pressure (IFP) Spatial Mapping CT Liposomes Micro CT Scanner Contrast Agent Imaging Protocols
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