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Cancer Research

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In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
 

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Article DOI: 10.3791/54532-v 12:03 min December 9th, 2016
December 9th, 2016

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요약

This manuscript describes the development of an animal model that allows for the direct testing of the effects of tumor hypoxia on metastasis and the deciphering the mechanisms of its action. Although the experiments described here focus on Ewing sarcoma, a similar approach can be applied to other tumor types.

Tags

Keywords: In Vivo Model Tumor Metastasis Hypoxia Ewing Sarcoma SCID Beige Mouse Femoral Artery Ligation Hind Limb Amputation Hypoxyprobe-1 Tumor Volume Surgical Procedure
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