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Immunology and Infection

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A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
 

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries

Article DOI: 10.3791/54829-v 09:39 min December 27th, 2016
December 27th, 2016

챕터

요약

Biofilm infections show high tolerance towards chemotherapy. No single assay captures the complexity of biofilms. Instead, complementary assays are needed. We present a screening platform (developed for S. aureus) that combines assays for viability, biomass, and biofilm matrix. It allows anti-biofilm drug discovery, including the assessment of long-term chemotherapeutic effects.

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Keywords: Anti-biofilm Assays Natural Compound Libraries Viability Biomass Biofilm Matrix Antibiofilm Agent Discovery Resazurin Staining Crystal Violet Staining 96-well Plate Planktonic Solution Biofilm Fluorescence Measurement
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