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JoVE Journal Medicine
Ultralydsvejledt Intracardiac injektion af humane mesenkymale stamceller til at øge Homing til tarmen til brug i Murine modeller af eksperimentelle inflammatoriske tarmsygdomme
 
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Ultralydsvejledt Intracardiac injektion af humane mesenkymale stamceller til at øge Homing til tarmen til brug i Murine modeller af eksperimentelle inflammatoriske tarmsygdomme

Article DOI: 10.3791/55367-v • 07:46 min • September 1st, 2017
September 1st, 2017 •
1, 1, 2,3, 5, 4, 2,3, 5, 1
1Division of Gastroenterology and Liver Disease, University Hospitals, Digestive Health Research Institute, Case Western Reserve University, 2Case Cardiovascular Research Institute, School of Medicine, Case Western Reserve University, 3Department of Medicine, Harrington Discovery Institute, Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, 4Department of Radiology, University Hospitals Case Medical Center, 5Department of Biology - Skeletal Research Center, Case Western Reserve University

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Murine undersøgelser i modeller af Colon betændelse har vist, at en lille procentdel (1-5%) af mesenchymale stamceller (MSC) injiceres intravenøst eller intraperitoneal hjem til den betændte kolon1,2. Denne undersøgelse viser, at ultralydsvejledt intracardiac injektioner af MSCs resultere i øget lokalisering til tarmen.

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Medicin sag 127 mesenchymale stamceller (MSC) Crohns sygdom SAMP1/YitFc ultralydsvejledt intracardiac injektion hMSC transduktion bioluminescens imaging
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