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Inducerende akut leverskade hos rotter via tetrachlormethan (CCl4)Eksponering gennem et orogastrisk rør
 
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Inducerende akut leverskade hos rotter via tetrachlormethan (CCl4)Eksponering gennem et orogastrisk rør

Article DOI: 10.3791/60695-v • 06:12 min • April 28th, 2020
April 28th, 2020 •
*1, *1, 2, 3, 1, 1, 4, 1, 1, 1
1Department of Anesthesiology and Critical Care, Soroka Medical Center, Ben-Gurion University of the Negev, 2Department of Anesthesiology, Yale University School of Medicine, 3Department of Neurosurgery, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, 4Department of Ophthalmology, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev
* These authors contributed equally

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Denne protokol beskriver en fælles og gennemførlig metode til at fremkalde akut leverskade (ALI) via CCl4 eksponering gennem et orogastrisk rør. Cl4 eksponering inducerer ALI gennem dannelsen af reaktive ilt arter under sin biotransformation i leveren. Denne metode bruges til at analysere patofysiologi af ALI og undersøge forskellige hepatoprotective strategier.

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Medicin akut leverskade (ALI) tetrachlormethan (CCl4),leverskade leverskader rottemodel toksin
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