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Journal / Medicine / 在几种肾脏疾病小鼠模型中使用聚乙烯亚胺纳米颗粒将外源人工合成的miRNA模拟物递送到肾脏…
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在几种肾脏疾病小鼠模型中使用聚乙烯亚胺纳米颗粒将外源人工合成的miRNA模拟物递送到肾脏
 
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在几种肾脏疾病小鼠模型中使用聚乙烯亚胺纳米颗粒将外源人工合成的miRNA模拟物递送到肾脏

Article DOI: 10.3791/63302-v • 07:01 min • May 10th, 2022
May 10th, 2022 •
*1, 1, 1, 1, *1
1Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University
* These authors contributed equally

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在这里，我们通过在几种肾脏疾病小鼠模型中通过尾静脉注射非病毒载体和聚乙烯亚胺纳米颗粒 将 外源人工合成的miRNA模拟物输送到肾脏。这导致靶miRNA在肾脏中的显着过表达，导致几种小鼠模型中肾脏疾病的进展受到抑制。

Tags

医学，第183期，基因治疗，递送，肾脏疾病，microRNA，非病毒载体，聚乙烯亚胺纳米颗粒
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