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Journal / Medicine / 直腸オルガノイド形態分析(ROMA):嚢胞性線維症の診断アッセイ…
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直腸オルガノイド形態分析(ROMA)
 
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直腸オルガノイド形態分析(ROMA):嚢胞性線維症の診断アッセイ

Article DOI: 10.3791/63818-v • 07:56 min • June 10th, 2022
June 10th, 2022 •
1,2, 1, 3,4, 5, 6, 7,8, 7,9, 8, 3,4, 1,2, 1,2, 10,11, 1,2, 1,2
1Department of Development and Regeneration, Woman and Child Unit, CF research lab, KU Leuven, 2Department of Pediatrics, Pediatric Pulmonology, University Hospitals Leuven, 3VIB Bio Imaging Core, VIB-KU Leuven Center for Brain & Disease Research, 4Department for Neuroscience, KU Leuven, 5Interuniversity Center for Biostatistics and Statistical Bioinformatics, University of Leuven and University of Hasselt, 6Department of Pediatrics, 2nd Faculty of Medicine, Charles University and Motol University Hospital, 7Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, 8Department of Development and Regeneration, Stem Cell Institute Leuven (SCIL), KU Leuven, 9Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, 10Department of Chronic Diseases, Metabolism and Ageing; Pneumology, KU Leuven, 11Department of Respiratory Diseases, University Hospitals Leuven

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このプロトコルは、嚢胞性線維症(CF)の新しい診断アッセイである直腸オルガノイド形態分析(ROMA)について説明しています。形態学的特徴、すなわち真円度(円形度指数、CI)および内腔の存在(強度比、IR)は、CFTR機能の尺度である。189人の被験者の分析は、CFと非CFの間の完全な識別を示しました。

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医学、第184号、
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