Aik-Choon Tan Medicine University of Colorado Denver Anschutz Medical Campus Biography Publications Institution JoVE Articles Aik-Choon Tan has not added a biography. If you are Aik-Choon Tan and would like to personalize this page please email our Author Liaison for assistance. Publications Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2 Journal of the National Cancer Institute. Jan, 2017 | Pubmed ID: 27634934 AZ1366: An Inhibitor of Tankyrase and the Canonical Wnt Pathway That Limits the Persistence of Non-small Cell Lung Cancer Cells Following EGFR Inhibition Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2016 | Pubmed ID: 27663586 Big Data Mining and Adverse Event Pattern Analysis in Clinical Drug Trials Assay and Drug Development Technologies. Sep, 2016 | Pubmed ID: 27631620 Treating Experimental Arthritis with the Innate Immune Inhibitor Interleukin-37 Reduces Joint and Systemic Inflammation Rheumatology (Oxford, England). Aug, 2016 | Pubmed ID: 27567100 Systematic Analysis of Tumour Cell-extracellular Matrix Adhesion Identifies Independent Prognostic Factors in Breast Cancer Oncotarget. Aug, 2016 | Pubmed ID: 27556857 Barasertib (AZD1152), a Small Molecule Aurora B Inhibitor, Inhibits the Growth of SCLC Cell Lines In Vitro and In Vivo Molecular Cancer Therapeutics. Aug, 2016 | Pubmed ID: 27496133 HiPub: Translating PubMed and PMC Texts to Networks for Knowledge Discovery Bioinformatics (Oxford, England). Sep, 2016 | Pubmed ID: 27485446 Exploiting Receptor Tyrosine Kinase Co-activation for Cancer Therapy Drug Discovery Today. Jul, 2016 | Pubmed ID: 27452454 Antitumor Activity of the Aurora a Selective Kinase Inhibitor, Alisertib, Against Preclinical Models of Colorectal Cancer Oncotarget. Jul, 2016 | Pubmed ID: 27385211 Integrating Heterogeneous Drug Sensitivity Data from Cancer Pharmacogenomic Studies Oncotarget. Jun, 2016 | Pubmed ID: 27322211 The Mitogen-Activated Protein Kinase Pathway Facilitates Resistance to the Src Inhibitor Dasatinib in Thyroid Cancer Molecular Cancer Therapeutics. Aug, 2016 | Pubmed ID: 27222538 BRONCO: Biomedical Entity Relation ONcology COrpus for Extracting Gene-variant-disease-drug Relations Database : the Journal of Biological Databases and Curation. 2016 | Pubmed ID: 27074804 Genetically-defined Novel Oral Squamous Cell Carcinoma Cell Lines for the Development of Molecular Therapies Oncotarget. May, 2016 | Pubmed ID: 27050151 IMPACT: a Whole-exome Sequencing Analysis Pipeline for Integrating Molecular Profiles with Actionable Therapeutics in Clinical Samples Journal of the American Medical Informatics Association : JAMIA. Jul, 2016 | Pubmed ID: 27026619 PKCδ Regulates Integrin αVβ3 Expression and Transformed Growth of K-ras Dependent Lung Cancer Cells Oncotarget. Apr, 2016 | Pubmed ID: 26918447 A Pilot Study of Cetuximab and the Hedgehog Inhibitor IPI-926 in Recurrent/metastatic Head and Neck Squamous Cell Carcinoma Oral Oncology. Feb, 2016 | Pubmed ID: 26705064 Expanding the Computational Toolbox for Interrogating Cancer Kinomes Pharmacogenomics. 2016 | Pubmed ID: 26666839 A NOTCH1 Gene Copy Number Gain is a Prognostic Indicator of Worse Survival and a Predictive Biomarker to a Notch1 Targeting Antibody in Colorectal Cancer International Journal of Cancer. Jan, 2016 | Pubmed ID: 26152787 The Six1 Oncoprotein Downregulates P53 Via Concomitant Regulation of RPL26 and MicroRNA-27a-3p Nature Communications. 2015 | Pubmed ID: 26687066 An Integrated Bioinformatics Analysis to Dissect Kinase Dependency in Triple Negative Breast Cancer BMC Genomics. 2015 | Pubmed ID: 26681397 Aging-associated Inflammation Promotes Selection for Adaptive Oncogenic Events in B Cell Progenitors The Journal of Clinical Investigation. Dec, 2015 | Pubmed ID: 26551682 Antitumor Activity of a Potent MEK Inhibitor, TAK-733, Against Colorectal Cancer Cell Lines and Patient Derived Xenografts Oncotarget. Oct, 2015 | Pubmed ID: 26439693 Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC Cancer Research. Oct, 2015 | Pubmed ID: 26359452 Identifying Kinase Dependency in Cancer Cells by Integrating High-throughput Drug Screening and Kinase Inhibition Data Bioinformatics (Oxford, England). Dec, 2015 | Pubmed ID: 26206305 ICOSSY: An Online Tool for Context-Specific Subnetwork Discovery from Gene Expression Data PloS One. 2015 | Pubmed ID: 26147457 Combined Inhibition of MEK and Aurora A Kinase in KRAS/PIK3CA Double-mutant Colorectal Cancer Models Frontiers in Pharmacology. 2015 | Pubmed ID: 26136684 Comparative Haploid Genetic Screens Reveal Divergent Pathways in the Biogenesis and Trafficking of Glycophosphatidylinositol-Anchored Proteins Cell Reports. Jun, 2015 | Pubmed ID: 26074080 FGFR1 Expression Levels Predict BGJ398 Sensitivity of FGFR1-Dependent Head and Neck Squamous Cell Cancers Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2015 | Pubmed ID: 26015511 DSigDB: Drug Signatures Database for Gene Set Analysis Bioinformatics (Oxford, England). Sep, 2015 | Pubmed ID: 25990557 An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases PloS One. 2015 | Pubmed ID: 25946135 RIP1 Negatively Regulates Basal Autophagic Flux Through TFEB to Control Sensitivity to Apoptosis EMBO Reports. Jun, 2015 | Pubmed ID: 25908842 P53 Family Members Regulate Phenotypic Response to Aurora Kinase A Inhibition in Triple-Negative Breast Cancer Molecular Cancer Therapeutics. May, 2015 | Pubmed ID: 25758253 Systems Biology Approaches for Advancing the Discovery of Effective Drug Combinations Journal of Cheminformatics. 2015 | Pubmed ID: 25741385 TWIST1-Induced MiR-424 Reversibly Drives Mesenchymal Programming While Inhibiting Tumor Initiation Cancer Research. May, 2015 | Pubmed ID: 25716682 Contrasting Roles for C/EBPα and Notch in Irradiation-induced Multipotent Hematopoietic Progenitor Cell Defects Stem Cells (Dayton, Ohio). Apr, 2015 | Pubmed ID: 25546133 Antitumor Activity of the MEK Inhibitor TAK-733 Against Melanoma Cell Lines and Patient-derived Tumor Explants Molecular Cancer Therapeutics. Feb, 2015 | Pubmed ID: 25376610 Potent Antitumor Activity of Cabozantinib, a C-MET and VEGFR2 Inhibitor, in a Colorectal Cancer Patient-derived Tumor Explant Model International Journal of Cancer. Apr, 2015 | Pubmed ID: 25242168 Dual Pharmacological Targeting of the MAP Kinase and PI3K/mTOR Pathway in Preclinical Models of Colorectal Cancer PloS One. 2014 | Pubmed ID: 25401499 Long Term Storage of Dry Versus Frozen RNA for Next Generation Molecular Studies PloS One. 2014 | Pubmed ID: 25380187 Homeoprotein Six2 Promotes Breast Cancer Metastasis Via Transcriptional and Epigenetic Control of E-cadherin Expression Cancer Research. Dec, 2014 | Pubmed ID: 25348955 Bioinformatics-driven Discovery of Rational Combination for Overcoming EGFR-mutant Lung Cancer Resistance to EGFR Therapy Bioinformatics (Oxford, England). Sep, 2014 | Pubmed ID: 24812339 FGFR1 MRNA and Protein Expression, Not Gene Copy Number, Predict FGFR TKI Sensitivity Across All Lung Cancer Histologies Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2014 | Pubmed ID: 24771645 Thioredoxin Interacting Protein (TXNIP) is a Novel Tumor Suppressor in Thyroid Cancer Molecular Cancer. 2014 | Pubmed ID: 24645981 Automatic Context-specific Subnetwork Discovery from Large Interaction Networks PloS One. 2014 | Pubmed ID: 24392115 BEReX: Biomedical Entity-Relationship EXplorer Bioinformatics (Oxford, England). Jan, 2014 | Pubmed ID: 24149052 Resistance to ROS1 Inhibition Mediated by EGFR Pathway Activation in Non-small Cell Lung Cancer PloS One. 2013 | Pubmed ID: 24349229 DNA Methylation Profiling Revealed Promoter Hypermethylation-induced Silencing of P16, DDAH2 and DUSP1 in Primary Oral Squamous Cell Carcinoma International Journal of Medical Sciences. 2013 | Pubmed ID: 24155659 K-Map: Connecting Kinases with Therapeutics for Drug Repurposing and Development Human Genomics. 2013 | Pubmed ID: 24060470 From Bench to Bedside: Lessons Learned in Translating Preclinical Studies in Cancer Drug Development Journal of the National Cancer Institute. Oct, 2013 | Pubmed ID: 24052618 Overcoming IGF1R/IR Resistance Through Inhibition of MEK Signaling in Colorectal Cancer Models Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2013 | Pubmed ID: 24045180 The Dual Pathway Inhibitor Rigosertib is Effective in Direct Patient Tumor Xenografts of Head and Neck Squamous Cell Carcinomas Molecular Cancer Therapeutics. Oct, 2013 | Pubmed ID: 23873848 Mer Receptor Tyrosine Kinase is a Therapeutic Target in Pre-B-cell Acute Lymphoblastic Leukemia Blood. Aug, 2013 | Pubmed ID: 23861246 Collagen Architecture in Pregnancy-induced Protection from Breast Cancer Journal of Cell Science. Sep, 2013 | Pubmed ID: 23843613 Rational Combination of a MEK Inhibitor, Selumetinib, and the Wnt/calcium Pathway Modulator, Cyclosporin A, in Preclinical Models of Colorectal Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2013 | Pubmed ID: 23757356 A Genetic Screen Identifies TCF3/E2A and TRIAP1 As Pathway-specific Regulators of the Cellular Response to P53 Activation Cell Reports. May, 2013 | Pubmed ID: 23684607 A Patient Tumor Transplant Model of Squamous Cell Cancer Identifies PI3K Inhibitors As Candidate Therapeutics in Defined Molecular Bins Molecular Oncology. Aug, 2013 | Pubmed ID: 23607916 MERTK Receptor Tyrosine Kinase is a Therapeutic Target in Melanoma The Journal of Clinical Investigation. May, 2013 | Pubmed ID: 23585477 Association of the Epithelial-to-mesenchymal Transition Phenotype with Responsiveness to the P21-activated Kinase Inhibitor, PF-3758309, in Colon Cancer Models Frontiers in Pharmacology. 2013 | Pubmed ID: 23543898 Tumor P-Glycoprotein Correlates with Efficacy of PF-3758309 in in Vitro and in Vivo Models of Colorectal Cancer Frontiers in Pharmacology. 2013 | Pubmed ID: 23524533 Genomic Signatures of Pregnancy-associated Breast Cancer Epithelia and Stroma and Their Regulation by Estrogens and Progesterone Hormones & Cancer. Jun, 2013 | Pubmed ID: 23479404 A Receptor Tyrosine Kinase Network Composed of Fibroblast Growth Factor Receptors, Epidermal Growth Factor Receptor, V-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 2, and Hepatocyte Growth Factor Receptor Drives Growth and Survival of Head and Neck Squamous Carcinoma Cell Lines Molecular Pharmacology. Apr, 2013 | Pubmed ID: 23371912 Predictive Biomarkers of Sensitivity to the Aurora and Angiogenic Kinase Inhibitor ENMD-2076 in Preclinical Breast Cancer Models Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2013 | Pubmed ID: 23136197 Plasma-based Circulating MicroRNA Biomarkers for Parkinson's Disease Journal of Parkinson's Disease. 2012 | Pubmed ID: 23938262 Biomarker-driven Trial in Metastatic Pancreas Cancer: Feasibility in a Multicenter Study of Saracatinib, an Oral Src Inhibitor, in Previously Treated Pancreatic Cancer Cancer Medicine. Oct, 2012 | Pubmed ID: 23342270 Obesity and Overfeeding Affecting Both Tumor and Systemic Metabolism Activates the Progesterone Receptor to Contribute to Postmenopausal Breast Cancer Cancer Research. Dec, 2012 | Pubmed ID: 23222299 Tankyrase and the Canonical Wnt Pathway Protect Lung Cancer Cells from EGFR Inhibition Cancer Research. Aug, 2012 | Pubmed ID: 22738915 ATM and MET Kinases Are Synthetic Lethal with Nongenotoxic Activation of P53 Nature Chemical Biology. Jul, 2012 | Pubmed ID: 22660439 Common PIK3CA Mutants and a Novel 3' UTR Mutation Are Associated with Increased Sensitivity to Saracatinib Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2012 | Pubmed ID: 22553375 ALDH+ Tumor-initiating Cells Exhibiting Gain in NOTCH1 Gene Copy Number Have Enhanced Regrowth Sensitivity to a γ-secretase Inhibitor and Irinotecan in Colorectal Cancer Molecular Oncology. Jun, 2012 | Pubmed ID: 22521243 Patient-derived Tumour Xenografts As Models for Oncology Drug Development Nature Reviews. Clinical Oncology. Jun, 2012 | Pubmed ID: 22508028 Preclinical Activity of the Rational Combination of Selumetinib (AZD6244) in Combination with Vorinostat in KRAS-mutant Colorectal Cancer Models Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2012 | Pubmed ID: 22173548 BiNGS!SL-seq: a Bioinformatics Pipeline for the Analysis and Interpretation of Deep Sequencing Genome-wide Synthetic Lethal Screen Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22130895 Employing Gene Set Top Scoring Pairs to Identify Deregulated Pathway-signatures in Dilated Cardiomyopathy from Integrated Microarray Gene Expression Data Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22130892 Direct Reprogramming of Human Fibroblasts into Dopaminergic Neuron-like Cells Cell Research. Feb, 2012 | Pubmed ID: 22105488 Maintenance of Hormone Responsiveness in Luminal Breast Cancers by Suppression of Notch Proceedings of the National Academy of Sciences of the United States of America. Feb, 2012 | Pubmed ID: 21969591 1628 人样本的 DNA 甲基化指纹。 Genome Research. Feb, 2012 | Pubmed ID: 21613409 Host Response Transcriptional Profiling Reveals Extracellular Components and ABC (ATP-binding Cassette) Transporters Gene Enrichment in Typhoid Fever-infected Nigerian Children BMC Infectious Diseases. 2011 | Pubmed ID: 21914192 Postpartum Mammary Gland Involution Drives Progression of Ductal Carcinoma in Situ Through Collagen and COX-2 Nature Medicine. Sep, 2011 | Pubmed ID: 21822285 Tumor Engraftment in Nude Mice and Enrichment in Stroma- Related Gene Pathways Predict Poor Survival and Resistance to Gemcitabine in Patients with Pancreatic Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2011 | Pubmed ID: 21742805 Caspase 3-mediated Stimulation of Tumor Cell Repopulation During Cancer Radiotherapy Nature Medicine. Jul, 2011 | Pubmed ID: 21725296 MIR29B Regulates Expression of MLLT11 (AF1Q), an MLL Fusion Partner, and Low MIR29B Expression Associates with Adverse Cytogenetics and Poor Overall Survival in AML British Journal of Haematology. Jun, 2011 | Pubmed ID: 21496004 A Short Survey of Computational Analysis Methods in Analysing ChIP-seq Data Human Genomics. Jan, 2011 | Pubmed ID: 21296745 Confident Predictability: Identifying Reliable Gene Expression Patterns for Individualized Tumor Classification Using a Local Minimax Kernel Algorithm BMC Medical Genomics. 2011 | Pubmed ID: 21261972 A Survey of Statistical Software for Analysing RNA-seq Data Human Genomics. Oct, 2010 | Pubmed ID: 21106489 Optimizing the Detection of Lung Cancer Patients Harboring Anaplastic Lymphoma Kinase (ALK) Gene Rearrangements Potentially Suitable for ALK Inhibitor Treatment Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2010 | Pubmed ID: 21062932 The Insulin-like Growth Factor I Receptor/insulin Receptor Tyrosine Kinase Inhibitor PQIP Exhibits Enhanced Antitumor Effects in Combination with Chemotherapy Against Colorectal Cancer Models Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2010 | Pubmed ID: 20943761 Identification of Predictive Markers of Response to the MEK1/2 Inhibitor Selumetinib (AZD6244) in K-ras-mutated Colorectal Cancer Molecular Cancer Therapeutics. Dec, 2010 | Pubmed ID: 20923857 Gene Array and Fluorescence in Situ Hybridization Biomarkers of Activity of Saracatinib (AZD0530), a Src Inhibitor, in a Preclinical Model of Colorectal Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2010 | Pubmed ID: 20682712 Development of an Integrated Genomic Classifier for a Novel Agent in Colorectal Cancer: Approach to Individualized Therapy in Early Development Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2010 | Pubmed ID: 20530704 Novel Agents in the Treatment of Metastatic Colorectal Cancer Cancer Journal (Sudbury, Mass.). May-Jun, 2010 | Pubmed ID: 20526106 Quantitative Proteomic Analysis of Ovarian Cancer Cells Identified Mitochondrial Proteins Associated with Paclitaxel Resistance Proteomics. Clinical Applications. Nov, 2009 | Pubmed ID: 21113235 A Resource for Analysis of MicroRNA Expression and Function in Pancreatic Ductal Adenocarcinoma Cells Cancer Biology & Therapy. Nov, 2009 | Pubmed ID: 20037478 Efficacy and Pharmacodynamic Effects of Bosutinib (SKI-606), a Src/Abl Inhibitor, in Freshly Generated Human Pancreas Cancer Xenografts Molecular Cancer Therapeutics. Jun, 2009 | Pubmed ID: 19509264 Antitumor Effects and Biomarkers of Activity of AZD0530, a Src Inhibitor, in Pancreatic Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2009 | Pubmed ID: 19509160 Characterizing DNA Methylation Patterns in Pancreatic Cancer Genome Molecular Oncology. Dec, 2009 | Pubmed ID: 19497796 Identification of Novel Serological Biomarkers for Inflammatory Bowel Disease Using Escherichia Coli Proteome Chip Molecular & Cellular Proteomics : MCP. Aug, 2009 | Pubmed ID: 19357087 Antitumor Activity and Molecular Effects of the Novel Heat Shock Protein 90 Inhibitor, IPI-504, in Pancreatic Cancer Molecular Cancer Therapeutics. Oct, 2008 | Pubmed ID: 18852131 Coordinated Epidermal Growth Factor Receptor Pathway Gene Overexpression Predicts Epidermal Growth Factor Receptor Inhibitor Sensitivity in Pancreatic Cancer Cancer Research. Apr, 2008 | Pubmed ID: 18413752 Merging Microarray Data from Separate Breast Cancer Studies Provides a Robust Prognostic Test BMC Bioinformatics. 2008 | Pubmed ID: 18304324 Allele-specific Expression in the Germline of Patients with Familial Pancreatic Cancer: an Unbiased Approach to Cancer Gene Discovery Cancer Biology & Therapy. Jan, 2008 | Pubmed ID: 18059179 Robust Prostate Cancer Marker Genes Emerge from Direct Integration of Inter-study Microarray Data Bioinformatics (Oxford, England). Oct, 2005 | Pubmed ID: 16131522 Simple Decision Rules for Classifying Human Cancers from Gene Expression Profiles Bioinformatics (Oxford, England). Oct, 2005 | Pubmed ID: 16105897 MSAT: a Multiple Sequence Alignment Tool Based on TOPS Applied Bioinformatics. 2004 | Pubmed ID: 15693740 Multi-class Protein Fold Classification Using a New Ensemble Machine Learning Approach Genome Informatics. International Conference on Genome Informatics. 2003 | Pubmed ID: 15706535 Ensemble Machine Learning on Gene Expression Data for Cancer Classification Applied Bioinformatics. 2003 | Pubmed ID: 15130820 开发和维护的临床前患者来源的肿瘤异种移植模型为新的抗癌疗法的调查 Stacey Bagby1, Wells A. Messersmith1, Todd M. Pitts1, Anna Capasso1, Marileila Varella-Garcia1, Peter J. Klauck1, Jihye Kim1, Aik-Choon Tan1, S. Gail Eckhardt1, John J. Tentler1, John Arcaroli1 1Medicine, University of Colorado Denver Anschutz Medical Campus JoVE 54393 Pesquisa do câncer
开发和维护的临床前患者来源的肿瘤异种移植模型为新的抗癌疗法的调查 Stacey Bagby1, Wells A. Messersmith1, Todd M. Pitts1, Anna Capasso1, Marileila Varella-Garcia1, Peter J. Klauck1, Jihye Kim1, Aik-Choon Tan1, S. Gail Eckhardt1, John J. Tentler1, John Arcaroli1 1Medicine, University of Colorado Denver Anschutz Medical Campus JoVE 54393 Pesquisa do câncer