Albert Jeltsch Institute of Biochemistry Stuttgart University Biography Publications Institution JoVE Articles Albert Jeltsch has not added a biography. If you are Albert Jeltsch and would like to personalize this page please email our Author Liaison for assistance. Publications Application of Histone Modification-specific Interaction Domains As an Alternative to Antibodies Genome Research. Nov, 2014 | Pubmed ID: 25301795 Cooperative DNA Binding and Protein/DNA Fiber Formation Increases the Activity of the Dnmt3a DNA Methyltransferase The Journal of Biological Chemistry. Oct, 2014 | Pubmed ID: 25147181 Role of Somatic Cancer Mutations in Human Protein Lysine Methyltransferases Biochimica Et Biophysica Acta. Aug, 2014 | Pubmed ID: 25123655 Regulation of DNA Methylation Patterns by CK2-mediated Phosphorylation of Dnmt3a Cell Reports. Aug, 2014 | Pubmed ID: 25066127 New Concepts in DNA Methylation Trends in Biochemical Sciences. Jul, 2014 | Pubmed ID: 24947342 Label-free Measurement of Histone Lysine Methyltransferases Activity by Matrix-assisted Laser Desorption/ionization Time-of-flight Mass Spectrometry Analytical Biochemistry. Jul, 2014 | Pubmed ID: 24747023 The Dnmt2 RNA Methyltransferase Homolog of Geobacter Sulfurreducens Specifically Methylates TRNA-Glu Nucleic Acids Research. 2014 | Pubmed ID: 24711368 Design, Synthesis and Biological Evaluation of 4-amino-N- (4-aminophenyl)benzamide Analogues of Quinoline-based SGI-1027 As Inhibitors of DNA Methylation ChemMedChem. Mar, 2014 | Pubmed ID: 24678024 Targeted Mutagenesis Results in an Activation of DNA Methyltransferase 1 and Confirms an Autoinhibitory Role of Its RFTS Domain Chembiochem : a European Journal of Chemical Biology. Mar, 2014 | Pubmed ID: 24532244 Targeted Methylation of the Epithelial Cell Adhesion Molecule (EpCAM) Promoter to Silence Its Expression in Ovarian Cancer Cells PloS One. 2014 | Pubmed ID: 24489952 Substrate Specificity Analysis and Novel Substrates of the Protein Lysine Methyltransferase NSD1 Chemistry & Biology. Feb, 2014 | Pubmed ID: 24412544 The UHRF1 Protein Stimulates the Activity and Specificity of the Maintenance DNA Methyltransferase DNMT1 by an Allosteric Mechanism The Journal of Biological Chemistry. Feb, 2014 | Pubmed ID: 24368767 Synthesis and Evaluation of Analogues of N-phthaloyl-l-tryptophan (RG108) As Inhibitors of DNA Methyltransferase 1 Journal of Medicinal Chemistry. Jan, 2014 | Pubmed ID: 24328113 The Tudor Domain of the PHD Finger Protein 1 is a Dual Reader of Lysine Trimethylation at Lysine 36 of Histone H3 and Lysine 27 of Histone Variant H3t Journal of Molecular Biology. Apr, 2014 | Pubmed ID: 23954330 Non-radioactive Protein Lysine Methyltransferase Microplate Assay Based on Reading Domains ChemMedChem. Mar, 2014 | Pubmed ID: 23671032 Genomic Imprinting--the Struggle of the Genders at the Molecular Level Angewandte Chemie (International Ed. in English). Dec, 2013 | Pubmed ID: 24346936 Target Recognition, RNA Methylation Activity and Transcriptional Regulation of the Dictyostelium Discoideum Dnmt2-homologue (DnmA) Nucleic Acids Research. Oct, 2013 | Pubmed ID: 23877245 Multimerization of the Dnmt3a DNA Methyltransferase and Its Functional Implications Progress in Molecular Biology and Translational Science. 2013 | Pubmed ID: 23663978 Oxygen, Epigenetic Signaling, and the Evolution of Early Life Trends in Biochemical Sciences. Apr, 2013 | Pubmed ID: 23454078 Identification of Novel Inhibitors of DNA Methylation by Screening of a Chemical Library ACS Chemical Biology. Mar, 2013 | Pubmed ID: 23294304 Targeted Methylation and Gene Silencing of VEGF-A in Human Cells by Using a Designed Dnmt3a-Dnmt3L Single-chain Fusion Protein with Increased DNA Methylation Activity Journal of Molecular Biology. Feb, 2013 | Pubmed ID: 23220192 Pmt1, a Dnmt2 Homolog in Schizosaccharomyces Pombe, Mediates TRNA Methylation in Response to Nutrient Signaling Nucleic Acids Research. Dec, 2012 | Pubmed ID: 23074192 DNA Methyltransferase Inhibitors in Cancer: a Chemical and Therapeutic Patent Overview and Selected Clinical Studies Expert Opinion on Therapeutic Patents. Dec, 2012 | Pubmed ID: 23033952 Identification of ICAD-derived Peptides Capable of Inhibiting Caspase-activated DNase The FEBS Journal. Aug, 2012 | Pubmed ID: 22727028 Mechanistic Details of the DNA Recognition by the Dnmt1 DNA Methyltransferase FEBS Letters. Jun, 2012 | Pubmed ID: 22641038 DNA Interaction of the CcrM DNA Methyltransferase: a Mutational and Modeling Study Chembiochem : a European Journal of Chemical Biology. Jun, 2012 | Pubmed ID: 22639453 Specificity of Dnmt1 for Methylation of Hemimethylated CpG Sites Resides in Its Catalytic Domain Chemistry & Biology. May, 2012 | Pubmed ID: 22633409 Mapping the TRNA Binding Site on the Surface of Human DNMT2 Methyltransferase Biochemistry. Jun, 2012 | Pubmed ID: 22591353 The SET8 H4K20 Protein Lysine Methyltransferase Has a Long Recognition Sequence Covering Seven Amino Acid Residues Biochimie. Nov, 2012 | Pubmed ID: 22583696 A Fluorescence-based Supramolecular Tandem Assay for Monitoring Lysine Methyltransferase Activity in Homogeneous Solution Chemistry (Weinheim an Der Bergstrasse, Germany). Mar, 2012 | Pubmed ID: 22367964 Rapid Synthesis of New DNMT Inhibitors Derivatives of Procainamide Chembiochem : a European Journal of Chemical Biology. Jan, 2012 | Pubmed ID: 22170584 Using the Fluorescence Decay of 2-aminopurine to Investigate Conformational Change in the Recognition Sequence of the EcoRV DNA-(adenine-N6)-methyltransferase on Enzyme Binding Biophysical Chemistry. Jan, 2012 | Pubmed ID: 21962489 Function and Disruption of DNA Methyltransferase 3a Cooperative DNA Binding and Nucleoprotein Filament Formation Nucleic Acids Research. Jan, 2012 | Pubmed ID: 21926161 The Caulobacter Crescentus DNA-(adenine-N6)-methyltransferase CcrM Methylates DNA in a Distributive Manner Nucleic Acids Research. Feb, 2012 | Pubmed ID: 21926159 On the Evolutionary Origin of Eukaryotic DNA Methyltransferases and Dnmt2 PloS One. 2011 | Pubmed ID: 22140515 Epigenetics Europe Conference. Munich, Germany, 8-9 September 2011 Epigenomics. Dec, 2011 | Pubmed ID: 22126289 Burning off DNA Methylation: New Evidence for Oxygen-dependent DNA Demethylation Chembiochem : a European Journal of Chemical Biology. Nov, 2011 | Pubmed ID: 21998074 DNA Methyltransferase Assays Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21913079 Application of Celluspots Peptide Arrays for the Analysis of the Binding Specificity of Epigenetic Reading Domains to Modified Histone Tails BMC Biochemistry. 2011 | Pubmed ID: 21884582 C5-DNA Methyltransferase Inhibitors: from Screening to Effects on Zebrafish Embryo Development Chembiochem : a European Journal of Chemical Biology. Jun, 2011 | Pubmed ID: 21633996 Histone Tails Regulate DNA Methylation by Allosterically Activating De Novo Methyltransferase Cell Research. Aug, 2011 | Pubmed ID: 21606950 Oligomerization and Binding of the Dnmt3a DNA Methyltransferase to Parallel DNA Molecules: Heterochromatic Localization and Role of Dnmt3L The Journal of Biological Chemistry. Jul, 2011 | Pubmed ID: 21566127 The Inhibition of the Mammalian DNA Methyltransferase 3a (Dnmt3a) by Dietary Black Tea and Coffee Polyphenols BMC Biochemistry. 2011 | Pubmed ID: 21510884 Auto-methylation of the Mouse DNA-(cytosine C5)-methyltransferase Dnmt3a at Its Active Site Cysteine Residue The FEBS Journal. Jun, 2011 | Pubmed ID: 21481189 The ATRX-ADD Domain Binds to H3 Tail Peptides and Reads the Combined Methylation State of K4 and K9 Human Molecular Genetics. Jun, 2011 | Pubmed ID: 21421568 Approaches to Enzyme and Substrate Design of the Murine Dnmt3a DNA Methyltransferase Chembiochem : a European Journal of Chemical Biology. Jul, 2011 | Pubmed ID: 21400651 Specificity Analysis-based Identification of New Methylation Targets of the SET7/9 Protein Lysine Methyltransferase Chemistry & Biology. Jan, 2011 | Pubmed ID: 21276944 Structure and Function of Mammalian DNA Methyltransferases Chembiochem : a European Journal of Chemical Biology. Jan, 2011 | Pubmed ID: 21243710 Molecular Epigenetics: Connecting Human Biology and Disease with Little Marks Chembiochem : a European Journal of Chemical Biology. Jan, 2011 | Pubmed ID: 21243707 Detailed Specificity Analysis of Antibodies Binding to Modified Histone Tails with Peptide Arrays Epigenetics : Official Journal of the DNA Methylation Society. Feb, 2011 | Pubmed ID: 20962581 The Application of Next Generation Sequencing in DNA Methylation Analysis Genes. 2010 | Pubmed ID: 24710012 Mechanistic Insights on the Inhibition of C5 DNA Methyltransferases by Zebularine PloS One. 2010 | Pubmed ID: 20808780 Silencing of Gene Expression by Targeted DNA Methylation: Concepts and Approaches Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20680833 The Dnmt3a PWWP Domain Reads Histone 3 Lysine 36 Trimethylation and Guides DNA Methylation The Journal of Biological Chemistry. Aug, 2010 | Pubmed ID: 20547484 Molecular Biology. Phylogeny of Methylomes Science (New York, N.Y.). May, 2010 | Pubmed ID: 20466912 BISMA--fast and Accurate Bisulfite Sequencing Data Analysis of Individual Clones from Unique and Repetitive Sequences BMC Bioinformatics. 2010 | Pubmed ID: 20459626 Chromatin Methylation Activity of Dnmt3a and Dnmt3a/3L is Guided by Interaction of the ADD Domain with the Histone H3 Tail Nucleic Acids Research. Jul, 2010 | Pubmed ID: 20223770 Changing the DNA Recognition Specificity of the EcoDam DNA-(adenine-N6)-methyltransferase by Directed Evolution Journal of Molecular Biology. Jan, 2010 | Pubmed ID: 19766657 Non-imprinted Allele-specific DNA Methylation on Human Autosomes Genome Biology. 2009 | Pubmed ID: 19958531 New Clustering Module in BDPC Bisulfite Sequencing Data Presentation and Compilation Web Application for DNA Methylation Analyses BioTechniques. Sep, 2009 | Pubmed ID: 19852764 A Continuous Protein Methyltransferase (G9a) Assay for Enzyme Activity Measurement and Inhibitor Screening Journal of Biomolecular Screening. Oct, 2009 | Pubmed ID: 19734436 Transition from EcoDam to T4Dam DNA Recognition Mechanism Without Loss of Activity and Specificity Chembiochem : a European Journal of Chemical Biology. Oct, 2009 | Pubmed ID: 19725089 On the Divalent Metal Ion Dependence of DNA Cleavage by Restriction Endonucleases of the EcoRI Family Journal of Molecular Biology. Oct, 2009 | Pubmed ID: 19682999 The Ankyrin Repeat Domain of Huntingtin Interacting Protein 14 Contains a Surface Aromatic Cage, a Potential Site for Methyl-lysine Binding Proteins. Aug, 2009 | Pubmed ID: 19434754 DNA Methylation Analysis of Chromosome 21 Gene Promoters at Single Base Pair and Single Allele Resolution PLoS Genetics. Mar, 2009 | Pubmed ID: 19325872 Impact of 7,8-dihydro-8-oxoguanine on Methylation of the CpG Site by Dnmt3a Biochemistry. Feb, 2009 | Pubmed ID: 19161295 DNA Methylation Analysis by Bisulfite Conversion, Cloning, and Sequencing of Individual Clones Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 18987815 Specificity of Protein Lysine Methyltransferases and Methods for Detection of Lysine Methylation of Non-histone Proteins Molecular BioSystems. Dec, 2008 | Pubmed ID: 19396382 Formation of Nucleoprotein Filaments by Mammalian DNA Methyltransferase Dnmt3a in Complex with Regulator Dnmt3L Nucleic Acids Research. Dec, 2008 | Pubmed ID: 18945701 Reading and Writing DNA Methylation Nature Structural & Molecular Biology. Oct, 2008 | Pubmed ID: 18836494 Putting the Pieces Together: Histone H2B Ubiquitylation Directly Stimulates Histone H3K79 Methylation Chembiochem : a European Journal of Chemical Biology. Sep, 2008 | Pubmed ID: 18712750 Human DNMT2 Methylates TRNA(Asp) Molecules Using a DNA Methyltransferase-like Catalytic Mechanism RNA (New York, N.Y.). Aug, 2008 | Pubmed ID: 18567810 Protein Lysine Methyltransferase G9a Acts on Non-histone Targets Nature Chemical Biology. Jun, 2008 | Pubmed ID: 18438403 Persistent Downregulation of the Pancarcinoma-associated Epithelial Cell Adhesion Molecule Via Active Intranuclear Methylation International Journal of Cancer. Journal International Du Cancer. Jul, 2008 | Pubmed ID: 18398839 Cyclical DNA Methylation of a Transcriptionally Active Promoter Nature. Mar, 2008 | Pubmed ID: 18322525 Bisulfite Sequencing Data Presentation and Compilation (BDPC) Web Server--a Useful Tool for DNA Methylation Analysis Nucleic Acids Research. Mar, 2008 | Pubmed ID: 18296484 Detection and Quantitation of the Activity of DNA Methyltransferases Using a Biotin/avidin Microplate Assay Methods in Molecular Biology (Clifton, N.J.). 2008 | Pubmed ID: 18287657 Analysis of the Substrate Specificity of the Dim-5 Histone Lysine Methyltransferase Using Peptide Arrays Chemistry & Biology. Jan, 2008 | Pubmed ID: 18215768 Mapping of Protein-protein Interaction Sites by the 'absence of Interference' Approach Journal of Molecular Biology. Feb, 2008 | Pubmed ID: 18191145 Continuous Enzymatic Assay for Histone Lysine Methyltransferases BioTechniques. Nov, 2007 | Pubmed ID: 18072589 The M.EcoRV DNA-(adenine N6)-methyltransferase Uses DNA Bending for Recognition of an Expanded EcoDam Recognition Site The Journal of Biological Chemistry. Dec, 2007 | Pubmed ID: 17977824 Phosphorylation of Serine-515 Activates the Mammalian Maintenance Methyltransferase Dnmt1 Epigenetics : Official Journal of the DNA Methylation Society. Sep, 2007 | Pubmed ID: 17965600 Structure of Dnmt3a Bound to Dnmt3L Suggests a Model for De Novo DNA Methylation Nature. Sep, 2007 | Pubmed ID: 17713477 Deoxyribonucleic Acid Methyl Transferases 3a and 3b Associate with the Nuclear Orphan Receptor COUP-TFI During Gene Activation Molecular Endocrinology (Baltimore, Md.). Sep, 2007 | Pubmed ID: 17579209 Two Alternative Conformations of S-adenosyl-L-homocysteine Bound to Escherichia Coli DNA Adenine Methyltransferase and the Implication of Conformational Changes in Regulating the Catalytic Cycle The Journal of Biological Chemistry. Aug, 2007 | Pubmed ID: 17545164 Application of DNA Methyltransferases in Targeted DNA Methylation Applied Microbiology and Biotechnology. Jul, 2007 | Pubmed ID: 17431611 Reversible Inactivation of the CG Specific SssI DNA (cytosine-C5)-methyltransferase with a Photocleavable Protecting Group Chembiochem : a European Journal of Chemical Biology. Jan, 2007 | Pubmed ID: 17195251 Chimeric DNA Methyltransferases Target DNA Methylation to Specific DNA Sequences and Repress Expression of Target Genes Nucleic Acids Research. 2007 | Pubmed ID: 17151075 On the Enzymatic Properties of Dnmt1: Specificity, Processivity, Mechanism of Linear Diffusion and Allosteric Regulation of the Enzyme Epigenetics : Official Journal of the DNA Methylation Society. Apr-Jun, 2006 | Pubmed ID: 17965604 German Human Methylome Project Started Cancer Research. Jul, 2006 | Pubmed ID: 16849590 Two Substrates Are Better Than One: Dual Specificities for Dnmt2 Methyltransferases Trends in Biochemical Sciences. Jun, 2006 | Pubmed ID: 16679017 Mutations in DNA Methyltransferase DNMT3B in ICF Syndrome Affect Its Regulation by DNMT3L Human Molecular Genetics. May, 2006 | Pubmed ID: 16543361 Structure and Substrate Recognition of the Escherichia Coli DNA Adenine Methyltransferase Journal of Molecular Biology. Apr, 2006 | Pubmed ID: 16524590 Accuracy of DNA Methylation Pattern Preservation by the Dnmt1 Methyltransferase Nucleic Acids Research. 2006 | Pubmed ID: 16500889 Mutational Analysis of the Catalytic Domain of the Murine Dnmt3a DNA-(cytosine C5)-methyltransferase Journal of Molecular Biology. Mar, 2006 | Pubmed ID: 16472822 Developing a Programmed Restriction Endonuclease for Highly Specific DNA Cleavage Nucleic Acids Research. 2005 | Pubmed ID: 16356926 De Novo Methylation of Nucleosomal DNA by the Mammalian Dnmt1 and Dnmt3A DNA Methyltransferases Biochemistry. Jul, 2005 | Pubmed ID: 16026162 Avidin Plate Assay System for Enzymatic Characterization of a Histone Lysine Methyltransferase Analytical Biochemistry. Jul, 2005 | Pubmed ID: 15935324 Transition from Nonspecific to Specific DNA Interactions Along the Substrate-recognition Pathway of Dam Methyltransferase Cell. May, 2005 | Pubmed ID: 15882618 Profound Flanking Sequence Preference of Dnmt3a and Dnmt3b Mammalian DNA Methyltransferases Shape the Human Epigenome Journal of Molecular Biology. May, 2005 | Pubmed ID: 15854647 Mechanism of Stimulation of Catalytic Activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L The Journal of Biological Chemistry. Apr, 2005 | Pubmed ID: 15671018 Mechanism of Inhibition of DNA Methyltransferases by Cytidine Analogs in Cancer Therapy Cancer Biology & Therapy. Nov, 2004 | Pubmed ID: 15539938 Anomalous Mobility of Polymerase Chain Reaction Products After Bisulfite Treatment of DNA Analytical Biochemistry. Oct, 2004 | Pubmed ID: 15351297 The Dnmt1 DNA-(cytosine-C5)-methyltransferase Methylates DNA Processively with High Preference for Hemimethylated Target Sites The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15339928 Stopped-flow and Mutational Analysis of Base Flipping by the Escherichia Coli Dam DNA-(adenine-N6)-methyltransferase Journal of Molecular Biology. Aug, 2004 | Pubmed ID: 15276835 Chromatin Targeting of De Novo DNA Methyltransferases by the PWWP Domain The Journal of Biological Chemistry. Jun, 2004 | Pubmed ID: 14998998 Maintenance of Species Identity and Controlling Speciation of Bacteria: a New Function for Restriction/modification Systems? Gene. Oct, 2003 | Pubmed ID: 14604787 Structural and Biochemical Characterization of a New Mg(2+) Binding Site Near Tyr94 in the Restriction Endonuclease PvuII Journal of Molecular Biology. Aug, 2003 | Pubmed ID: 12888347 The Human Dnmt2 Has Residual DNA-(cytosine-C5) Methyltransferase Activity The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12794065 Catalytic Mechanism of DNA-(cytosine-C5)-methyltransferases Revisited: Covalent Intermediate Formation is Not Essential for Methyl Group Transfer by the Murine Dnmt3a Enzyme Journal of Molecular Biology. Jun, 2003 | Pubmed ID: 12787669 Methylation Sensitivity of Restriction Enzymes Interacting with GATC Sites BioTechniques. May, 2003 | Pubmed ID: 12765016 A Nomenclature for Restriction Enzymes, DNA Methyltransferases, Homing Endonucleases and Their Genes Nucleic Acids Research. Apr, 2003 | Pubmed ID: 12654995 Detection and Analysis of Enzymatic DNA Methylation of Oligonucleotide Substrates by Matrix-assisted Laser Desorption Ionization Time-of-flight Mass Spectrometry Analytical Biochemistry. Feb, 2003 | Pubmed ID: 12576072 High-throughput Purification of PolyHis-tagged Recombinant Fusion Proteins Methods in Molecular Biology (Clifton, N.J.). 2003 | Pubmed ID: 12491887 Probing the DNA Interface of the EcoRV DNA-(adenine-N6)-methyltransferase by Site-directed Mutagenesis, Fluorescence Spectroscopy, and UV Cross-linking Biochemistry. Dec, 2002 | Pubmed ID: 12450373 Dnmt3a and Dnmt1 Functionally Cooperate During De Novo Methylation of DNA European Journal of Biochemistry / FEBS. Oct, 2002 | Pubmed ID: 12383256 Specificity of DNA Triple Helix Formation Analyzed by a FRET Assay BMC Biochemistry. 2002 | Pubmed ID: 12323077 The Escherichia Coli Dam DNA Methyltransferase Modifies DNA in a Highly Processive Reaction Journal of Molecular Biology. Jun, 2002 | Pubmed ID: 12079349 A Fluorimetric Assay for On-line Detection of DNA Cleavage by Restriction Endonucleases Journal of Biotechnology. Jun, 2002 | Pubmed ID: 12039534 Beyond Watson and Crick: DNA Methylation and Molecular Enzymology of DNA Methyltransferases Chembiochem : a European Journal of Chemical Biology. Apr, 2002 | Pubmed ID: 11933228 Molecular Enzymology of the Catalytic Domains of the Dnmt3a and Dnmt3b DNA Methyltransferases The Journal of Biological Chemistry. Jun, 2002 | Pubmed ID: 11919202 Site-directed Mutagenesis by Polymerase Chain Reaction Methods in Molecular Biology (Clifton, N.J.). 2002 | Pubmed ID: 11768980 Specificiteit analyse van eiwit-lysine methyltransferases Met behulp van SPOT Peptide Arrays Srikanth Kudithipudi1, Denis Kusevic1, Sara Weirich1, Albert Jeltsch1 1Institute of Biochemistry, Stuttgart University Biologia
Specificiteit analyse van eiwit-lysine methyltransferases Met behulp van SPOT Peptide Arrays Srikanth Kudithipudi1, Denis Kusevic1, Sara Weirich1, Albert Jeltsch1 1Institute of Biochemistry, Stuttgart University Biologia