Alex Freeman Research Department of Pathology University College London Biography Publications Institution JoVE Articles Alex Freeman has not added a biography. If you are Alex Freeman and would like to personalize this page please email our Author Liaison for assistance. Publications Correction To: Machine Learning Classifiers Can Predict Gleason Pattern 4 Prostate Cancer with Greater Accuracy Than Experienced Radiologists European Radiology. Sep, 2019 | Pubmed ID: 31506815 Prediction of Significant Prostate Cancer in Biopsy-naïve Men: Validation of a Novel Risk Model Combining MRI and Clinical Parameters and Comparison to an ERSPC Risk Calculator and PI-RADS PloS One. 2019 | Pubmed ID: 31450235 A Multicentre Analysis of the Detection of Clinically Significant Prostate Cancer Following Transperineal Image-fusion Targeted and Nontargeted Systematic Prostate Biopsy in Men at Risk European Urology Oncology. Mar, 2019 | Pubmed ID: 31411968 Molecular and Histopathology Directed Therapy for Advanced Bladder Cancer Nature Reviews. Urology. Aug, 2019 | Pubmed ID: 31289379 NeuroSAFE Robot-assisted Laparoscopic Prostatectomy Versus Standard Robot-assisted Laparoscopic Prostatectomy for Men with Localised Prostate Cancer (NeuroSAFE PROOF): Protocol for a Randomised Controlled Feasibility Study BMJ Open. Jun, 2019 | Pubmed ID: 31189680 Machine Learning Classifiers Can Predict Gleason Pattern 4 Prostate Cancer with Greater Accuracy Than Experienced Radiologists European Radiology. Sep, 2019 | Pubmed ID: 31187216 Targeted Biopsy of the Prostate: Does This Result in Improvement in Detection of High-grade Cancer or the Occurrence of the Will Rogers Phenomenon? BJU International. May, 2019 | Pubmed ID: 31081983 Primary Squamous Cell Carcinoma of the Male Proximal Urethra: Outcomes from a Single Centre European Urology Focus. Mar, 2019 | Pubmed ID: 30853605 PEOPLE: PatiEnt PrOstate SamPLes for REsearch, a Tissue Collection Pathway Utilizing Magnetic Resonance Imaging Data to Target Tumor and Benign Tissue in Fresh Radical Prostatectomy Specimens The Prostate. May, 2019 | Pubmed ID: 30807665 VERDICT MRI Validation in Fresh and Fixed Prostate Specimens Using Patient-specific Moulds for Histological and MR Alignment NMR in Biomedicine. 05, 2019 | Pubmed ID: 30779863 Medium-term Oncological Outcomes in a Large Cohort of Men Treated with Either Focal or Hemi-ablation Using High-intensity Focused Ultrasonography for Primary Localized Prostate Cancer BJU International. Sep, 2019 | Pubmed ID: 30753756 Pathological Findings and Magnetic Resonance Imaging Concordance at Salvage Radical Prostatectomy for Local Recurrence Following Partial Ablation Using High Intensity Focused Ultrasound The Journal of Urology. 06, 2019 | Pubmed ID: 30730409 Training and Accreditation Standards for Pathologists Undertaking Clinical Trial Work The Journal of Pathology. Clinical Research. Apr, 2019 | Pubmed ID: 30680942 Dermatoscopic Findings of Penile Intraepithelial Neoplasia: Bowenoid Papulosis, Bowen Disease and Erythroplasia of Queyrat The Australasian Journal of Dermatology. Aug, 2019 | Pubmed ID: 30585302 The SmartTarget Biopsy Trial: A Prospective, Within-person Randomised, Blinded Trial Comparing the Accuracy of Visual-registration and Magnetic Resonance Imaging/Ultrasound Image-fusion Targeted Biopsies for Prostate Cancer Risk Stratification European Urology. 05, 2019 | Pubmed ID: 30527787 Multi-parametric MRI Zone-specific Diagnostic Model Performance Compared with Experienced Radiologists for Detection of Prostate Cancer European Radiology. Aug, 2019 | Pubmed ID: 30456585 Quality Assurance Guidance for Scoring and Reporting for Pathologists and Laboratories Undertaking Clinical Trial Work The Journal of Pathology. Clinical Research. Apr, 2019 | Pubmed ID: 30407751 VERDICT-AMICO: Ultrafast Fitting Algorithm for Non-invasive Prostate Microstructure Characterization NMR in Biomedicine. 01, 2019 | Pubmed ID: 30378195 Prostate Imaging Compared to Transperineal Ultrasound-guided Biopsy for Significant Prostate Cancer Risk Evaluation (PICTURE): a Prospective Cohort Validating Study Assessing Prostate HistoScanning Prostate Cancer and Prostatic Diseases. 05, 2019 | Pubmed ID: 30279583 Management of Radiologically Indeterminate Magnetic Resonance Imaging Signals in Men at Risk of Prostate Cancer European Urology Focus. 01, 2019 | Pubmed ID: 28753883 Prostate Cancer Diagnostic Pathway: Is a One-stop Cognitive MRI Targeted Biopsy Service a Realistic Goal in Everyday Practice? A Pilot Cohort in a Tertiary Referral Centre in the UK BMJ Open. 10, 2018 | Pubmed ID: 30361408 Urine-derived Lymphocytes As a Non-invasive Measure of the Bladder Tumor Immune Microenvironment The Journal of Experimental Medicine. 11, 2018 | Pubmed ID: 30257862 Immunohistochemical Biomarker Validation in Highly Selective Needle Biopsy Microarrays Derived from MpMRI-characterized Prostates The Prostate. 12, 2018 | Pubmed ID: 30073682 Multiparametric MRI to Improve Detection of Prostate Cancer Compared with Transrectal Ultrasound-guided Prostate Biopsy Alone: the PROMIS Study Health Technology Assessment (Winchester, England). 07, 2018 | Pubmed ID: 30040065 Accuracy of Transperineal Targeted Prostate Biopsies, Visual Estimation and Image Fusion in Men Needing Repeat Biopsy in the PICTURE Trial The Journal of Urology. 12, 2018 | Pubmed ID: 30017964 Patient Reported Outcome Measures for Transperineal Template Prostate Mapping Biopsies in the PICTURE Study The Journal of Urology. 12, 2018 | Pubmed ID: 29940251 MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis The New England Journal of Medicine. May, 2018 | Pubmed ID: 29552975 Phenotypic Appearances of Prostate Utilizing PET-MRI and PET-CT with 68Ga-PSMA, Radiolabelled Choline and 68Ga-DOTATATE Nuclear Medicine Communications. Mar, 2018 | Pubmed ID: 29384832 Characterizing Indeterminate (Likert-score 3/5) Peripheral Zone Prostate Lesions with PSA Density, PI-RADS Scoring and Qualitative Descriptors on Multiparametric MRI The British Journal of Radiology. Feb, 2018 | Pubmed ID: 29189042 The CADMUS Trial - Multi-parametric Ultrasound Targeted Biopsies Compared to Multi-parametric MRI Targeted Biopsies in the Diagnosis of Clinically Significant Prostate Cancer Contemporary Clinical Trials. 03, 2018 | Pubmed ID: 29108869 Predictive Factors for Local Recurrence After Glansectomy and Neoglans Reconstruction for Penile Squamous Cell Carcinoma Urologic Oncology. 04, 2018 | Pubmed ID: 28882673 Glansectomy and Split-thickness Skin Graft for Penile Cancer European Urology. 02, 2018 | Pubmed ID: 27746062 A Multicentre Randomised Controlled Trial Assessing Whether MRI-targeted Biopsy is Non-inferior to Standard Transrectal Ultrasound Guided Biopsy for the Diagnosis of Clinically Significant Prostate Cancer in Men Without Prior Biopsy: a Study Protocol BMJ Open. Oct, 2017 | Pubmed ID: 29025845 Apparatus for Histological Validation of and Magnetic Resonance Imaging of the Human Prostate Frontiers in Oncology. 2017 | Pubmed ID: 28393049 Spectrum of Metastatic and Nonmetastatic Skeletal Findings with Dual-phase 18F-FECH PET/CT in Patients with Biochemical Relapse of Prostate Cancer Nuclear Medicine Communications. May, 2017 | Pubmed ID: 28379896 The PICTURE Study: Diagnostic Accuracy of Multiparametric MRI in Men Requiring a Repeat Prostate Biopsy British Journal of Cancer. Apr, 2017 | Pubmed ID: 28350785 Port-Site Metastases After Robotic Radical Cystectomy: A Systematic Review and Management Options Clinical Genitourinary Cancer. 08, 2017 | Pubmed ID: 28209455 UroMark-a Urinary Biomarker Assay for the Detection of Bladder Cancer Clinical Epigenetics. 2017 | Pubmed ID: 28163793 Diagnostic Accuracy of Multi-parametric MRI and TRUS Biopsy in Prostate Cancer (PROMIS): a Paired Validating Confirmatory Study Lancet (London, England). 02, 2017 | Pubmed ID: 28110982 The Effect of Dutasteride on Magnetic Resonance Imaging Defined Prostate Cancer: MAPPED-A Randomized, Placebo Controlled, Double-Blind Clinical Trial The Journal of Urology. 04, 2017 | Pubmed ID: 27871928 Nanoknife Electroporation Ablation Trial: A Prospective Development Study Investigating Focal Irreversible Electroporation for Localized Prostate Cancer The Journal of Urology. 03, 2017 | Pubmed ID: 27697580 Prostate-specific Antigen Vs. Magnetic Resonance Imaging Parameters for Assessing Oncological Outcomes After High Intensity-focused Ultrasound Focal Therapy for Localized Prostate Cancer Urologic Oncology. 01, 2017 | Pubmed ID: 27663393 F-FECH PET/CT to Assess Clinically Significant Disease in Prostate Cancer: Correlation With Maximum and Total Cancer Core Length Obtained Via MRI-Guided Template Mapping Biopsies AJR. American Journal of Roentgenology. Dec, 2016 | Pubmed ID: 27611962 Does True Gleason Pattern 3 Merit Its Cancer Descriptor? Nature Reviews. Urology. 09, 2016 | Pubmed ID: 27530265 CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma Cancer Research. 08, 2016 | Pubmed ID: 27325650 What Burden of Prostate Cancer Can Radiologists Rule Out on Multiparametric Magnetic Resonance Imaging? A Sensitivity Analysis Based on Varying the Target Condition in Template Prostate Mapping Biopsies Urology. Sep, 2015 | Pubmed ID: 26253041 Visually Directed Vs. Software-based Targeted Biopsy Compared to Transperineal Template Mapping Biopsy in the Detection of Clinically Significant Prostate Cancer Urologic Oncology. Oct, 2015 | Pubmed ID: 26195330 Focal Ablation Targeted to the Index Lesion in Multifocal Localised Prostate Cancer: a Prospective Development Study European Urology. Dec, 2015 | Pubmed ID: 25682339 Zone-specific Logistic Regression Models Improve Classification of Prostate Cancer on Multi-parametric MRI European Radiology. Sep, 2015 | Pubmed ID: 25680730 An Unusual Swelling in the Male Perineum BMJ Case Reports. Jan, 2015 | Pubmed ID: 25612751 Epigenetics Markers of Metastasis and HPV-induced Tumorigenesis in Penile Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2015 | Pubmed ID: 25538261 Identifying the Index Lesion with Template Prostate Mapping Biopsies The Journal of Urology. Apr, 2015 | Pubmed ID: 25463987 Microstructural Characterization of Normal and Malignant Human Prostate Tissue with Vascular, Extracellular, and Restricted Diffusion for Cytometry in Tumours Magnetic Resonance Imaging Investigative Radiology. Apr, 2015 | Pubmed ID: 25426656 Logistic Regression Model for Diagnosis of Transition Zone Prostate Cancer on Multi-parametric MRI European Radiology. Feb, 2015 | Pubmed ID: 25226842 Loss of Expression of the Tumour Suppressor Gene AIMP3 Predicts Survival Following Radiotherapy in Muscle-invasive Bladder Cancer International Journal of Cancer. Journal International Du Cancer. Feb, 2015 | Pubmed ID: 24917520 A Prospective Development Study Investigating Focal Irreversible Electroporation in Men with Localised Prostate Cancer: Nanoknife Electroporation Ablation Trial (NEAT) Contemporary Clinical Trials. Sep, 2014 | Pubmed ID: 25072507 Gonadotrophin-independent Precocious Puberty Associated with Later Diagnosis of Testicular Embryonal Carcinoma Hormone Research in Paediatrics. 2014 | Pubmed ID: 25012595 Can Multiparametric Magnetic Resonance Imaging Predict Upgrading of Transrectal Ultrasound Biopsy Results at More Definitive Histology? Urologic Oncology. Aug, 2014 | Pubmed ID: 24981993 Changes in Mast Cell Number and Stem Cell Factor Expression in Human Skin After Radiotherapy for Breast Cancer Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology. May, 2014 | Pubmed ID: 24746564 The PICTURE Study -- Prostate Imaging (multi-parametric MRI and Prostate HistoScanning™) Compared to Transperineal Ultrasound Guided Biopsy for Significant Prostate Cancer Risk Evaluation Contemporary Clinical Trials. Jan, 2014 | Pubmed ID: 24291455 Prostate Cancer Tumour Features on Template Prostate-mapping Biopsies: Implications for Focal Therapy European Urology. Jul, 2014 | Pubmed ID: 24207133 Performance of Multiparametric MRI in Men at Risk of Prostate Cancer Before the First Biopsy: a Paired Validating Cohort Study Using Template Prostate Mapping Biopsies As the Reference Standard Prostate Cancer and Prostatic Diseases. Mar, 2014 | Pubmed ID: 24126797 The Accuracy of Multiparametric MRI in Men with Negative Biopsy and Elevated PSA Level--can It Rule out Clinically Significant Prostate Cancer? Urologic Oncology. Jan, 2014 | Pubmed ID: 24055430 Prostate Cancer Risk Inflation As a Consequence of Image-targeted Biopsy of the Prostate: a Computer Simulation Study European Urology. Mar, 2014 | Pubmed ID: 23312572 Quantitative Analysis of BTF3, HINT1, NDRG1 and ODC1 Protein Over-expression in Human Prostate Cancer Tissue PloS One. 2013 | Pubmed ID: 24386364 Prognostic Gleason Grade Grouping: Data Based on the Modified Gleason Scoring System BJU International. May, 2013 | Pubmed ID: 23578229 Evaluation of Retained Testes in Adolescent Girls and Women with Complete Androgen Insensitivity Syndrome Radiology. Jul, 2013 | Pubmed ID: 23533290 Genital Lichen Sclerosus/balanitis Xerotica Obliterans in Men with Penile Carcinoma: a Critical Analysis BJU International. May, 2013 | Pubmed ID: 23356463 Transperineal Magnetic Resonance Image Targeted Prostate Biopsy Versus Transperineal Template Prostate Biopsy in the Detection of Clinically Significant Prostate Cancer The Journal of Urology. Mar, 2013 | Pubmed ID: 23063807 Do Low-grade and Low-volume Prostate Cancers Bear the Hallmarks of Malignancy? The Lancet. Oncology. Nov, 2012 | Pubmed ID: 23117005 CD49f is an Efficient Marker of Monolayer- and Spheroid Colony-forming Cells of the Benign and Malignant Human Prostate PloS One. 2012 | Pubmed ID: 23071686 Focal Salvage Therapy for Localized Prostate Cancer Recurrence After External Beam Radiotherapy: a Pilot Study Cancer. Sep, 2012 | Pubmed ID: 22907704 Focal Therapy for Localised Unifocal and Multifocal Prostate Cancer: a Prospective Development Study The Lancet. Oncology. Jun, 2012 | Pubmed ID: 22512844 A Biopsy Simulation Study to Assess the Accuracy of Several Transrectal Ultrasonography (TRUS)-biopsy Strategies Compared with Template Prostate Mapping Biopsies in Patients Who Have Undergone Radical Prostatectomy BJU International. Sep, 2012 | Pubmed ID: 22394583 Whole-gland Salvage High-intensity Focused Ultrasound Therapy for Localized Prostate Cancer Recurrence After External Beam Radiation Therapy Cancer. Jun, 2012 | Pubmed ID: 22071795 Epithelioid Hemangioma of the Penis: Case Report and Review of Literature Journal of Medical Case Reports. Jun, 2011 | Pubmed ID: 21718503 Multi-parametric Magnetic Resonance Imaging to Rule-in and Rule-out Clinically Important Prostate Cancer in Men at Risk: a Cohort Study Urologia Internationalis. 2011 | Pubmed ID: 21701136 Characterizing Clinically Significant Prostate Cancer Using Template Prostate Mapping Biopsy The Journal of Urology. Aug, 2011 | Pubmed ID: 21679984 PCR-based Tissue Identification: the UCLH Experience Journal of Clinical Pathology. Oct, 2011 | Pubmed ID: 21617171 A Novel Role for Wnt/Ca2+ Signaling in Actin Cytoskeleton Remodeling and Cell Motility in Prostate Cancer PloS One. May, 2010 | Pubmed ID: 20454608 The Use of High-resolution Magnetic Resonance Imaging in the Management of Patients Presenting with Priapism BJU International. Dec, 2010 | Pubmed ID: 20438564 DNA Replication Licensing Factors and Aneuploidy Are Linked to Tumor Cell Cycle State and Clinical Outcome in Penile Carcinoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2009 | Pubmed ID: 19920109 Case Study: the Surgical Management of Angiokeratoma Resulting from Radiotherapy for Penile Cancer TheScientificWorldJournal. May, 2009 | Pubmed ID: 19468654 Is It Time to Consider a Role for MRI Before Prostate Biopsy? Nature Reviews. Clinical Oncology. Apr, 2009 | Pubmed ID: 19333226 Perineural and Lymphovascular Invasion on Prostatic Biopsy: Pathological Assessment and Significance Surgical Oncology. Sep, 2009 | Pubmed ID: 19299122 Utility of Tissue Microarrays for Profiling Prognostic Biomarkers in Clinically Localized Prostate Cancer: the Expression of BCL-2, E-cadherin, Ki-67 and P53 As Predictors of Biochemical Failure After Radical Prostatectomy with Nested Control for Clinical and Pathological Risk Factors Asian Journal of Andrology. Jan, 2009 | Pubmed ID: 19050681 Paraganglioma of the Spermatic Cord: Case Report and Review of the Literature TheScientificWorldJournal. Dec, 2008 | Pubmed ID: 19112537 The Feasibility and Safety of High-intensity Focused Ultrasound As Salvage Therapy for Recurrent Prostate Cancer Following External Beam Radiotherapy BJU International. Sep, 2008 | Pubmed ID: 18564135 Investigating the Effects of High-dose Phenylephrine in the Management of Prolonged Ischaemic Priapism The Journal of Sexual Medicine. Sep, 2008 | Pubmed ID: 18466270 MR Imaging of Prostate After Treatment with High-intensity Focused Ultrasound Radiology. Mar, 2008 | Pubmed ID: 18223121 Paraneoplastic Cushing's Syndrome in Prostate Cancer: a Difficult Management Problem BJU International. Feb, 2008 | Pubmed ID: 18070179 Allelic Imbalance at 13q14.2 Approximately Q14.3 in Localized Prostate Cancer is Associated with Early Biochemical Relapse Cancer Genetics and Cytogenetics. Dec, 2007 | Pubmed ID: 18036398 Plexin-B1 Mutations in Prostate Cancer Proceedings of the National Academy of Sciences of the United States of America. Nov, 2007 | Pubmed ID: 18024597 A Review of the Efficacy of Surgical Treatment for and Pathological Changes in Patients with Chronic Scrotal Pain BJU International. May, 2007 | Pubmed ID: 17244279 What Surgical Resection Margins Are Required to Achieve Oncological Control in Men with Primary Penile Cancer? BJU International. Nov, 2005 | Pubmed ID: 16225525 Radical Prostatectomy: Pathology Findings in 1001 Cases Compared with Other Major Series and over Time BJU International. Jan, 2005 | Pubmed ID: 15638892 Comparison of the Zones of the Human Prostate with the Seminal Vesicle: Morphology, Immunohistochemistry, and Cell Kinetics The Prostate. Feb, 2005 | Pubmed ID: 15389778 Differential Expression of CD44 During Human Prostate Epithelial Cell Differentiation The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Aug, 2004 | Pubmed ID: 15258184 Clinical Features of Patients Who Present with Metastatic Prostate Carcinoma and Serum Prostate-specific Antigen (PSA) Levels < 10 Ng/mL: the "PSA Negative" Patients Cancer. Dec, 2003 | Pubmed ID: 14635070 Användning av magnetisk resonanstomografi och Biopsidata för att vägleda provtagnings procedurer för biobanker för prostata cancer Susan Heavey1, Aiman Haider2, Ashwin Sridhar3, Hayley Pye1, Greg Shaw1, Alex Freeman2, Hayley Whitaker1 1Molecular Diagnostics and Therapeutics Group, University College London, 2Research Department of Pathology, University College London, 3Department of Uro-Oncology, UCLH NHS Foundation Trust JoVE 60216 Medicina
Användning av magnetisk resonanstomografi och Biopsidata för att vägleda provtagnings procedurer för biobanker för prostata cancer Susan Heavey1, Aiman Haider2, Ashwin Sridhar3, Hayley Pye1, Greg Shaw1, Alex Freeman2, Hayley Whitaker1 1Molecular Diagnostics and Therapeutics Group, University College London, 2Research Department of Pathology, University College London, 3Department of Uro-Oncology, UCLH NHS Foundation Trust JoVE 60216 Medicina