Alexander L Klibanov Robert M. Berne Cardiovascular Research Center University of Virginia Biography Publications Institution JoVE Articles Alexander L Klibanov has not added a biography. If you are Alexander L Klibanov and would like to personalize this page please email our Author Liaison for assistance. Publications Ultrasound Molecular Imaging of Cancer: Design and Formulation Strategies of Targeted Contrast Agents Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer. 2020 | Pubmed ID: 32594391 Targeted Ultrasound Contrast Imaging of Tumor Vasculature With Positively Charged Microbubbles Investigative Radiology. Jun, 2020 | Pubmed ID: 32569011 Augmentation of Brain Tumor Interstitial Flow Via Focused Ultrasound Promotes Brain-penetrating Nanoparticle Dispersion and Transfection Science Advances. May, 2020 | Pubmed ID: 32494662 Closed-loop Feedback Control of Microbubble Diameter from a Flow-focusing Microfluidic Device Biomicrofluidics. May, 2020 | Pubmed ID: 32454925 Sonoselective Transfection of Cerebral Vasculature Without Blood-brain Barrier Disruption Proceedings of the National Academy of Sciences of the United States of America. 03, 2020 | Pubmed ID: 32123081 Liposomal Delivery of PPARα/γ Dual Agonist Tesaglitazar in a Model of Obesity Enriches Macrophage Targeting and Limits Liver and Kidney Drug Effects Theranostics. 2020 | Pubmed ID: 31903139 Pulsed Ultrasound Attenuates the Hyperglycemic Exacerbation of Myocardial Ischemia-reperfusion Injury The Journal of Thoracic and Cardiovascular Surgery. Nov, 2019 | Pubmed ID: 31839230 Importance of Thorough Tissue and Cellular Level Characterization of Targeted Drugs in the Evaluation of Pharmacodynamic Effects PloS One. 2019 | Pubmed ID: 31725756 Monitoring Oxygenation Levels Deep in the Tumor Core: Noninvasive Imaging of Hypoxia, Now in Real-Time 3D Cancer Research. Sep, 2019 | Pubmed ID: 31519775 Validation of Normalized Singular Spectrum Area As a Classifier for Molecularly Targeted Microbubble Adherence Ultrasound in Medicine & Biology. 09, 2019 | Pubmed ID: 31227262 Correction: A Flow Focusing Microfluidic Device with an Integrated Coulter Particle Counter for Production, Counting and Size Characterization of Monodisperse Microbubbles Lab on a Chip. 05, 2019 | Pubmed ID: 31026008 Moving Toward Noninvasive, Focused Ultrasound Therapeutic Delivery of Drugs in the Brain: Prolonged Opening of Blood-Brain Barrier May Not Be Needed Radiology. May, 2019 | Pubmed ID: 30917292 Efficacy of Sonothrombolysis Using Microbubbles Produced by a Catheter-Based Microfluidic Device in a Rat Model of Ischemic Stroke Annals of Biomedical Engineering. Apr, 2019 | Pubmed ID: 30689066 Formation of Microbubbles for Targeted Ultrasound Contrast Imaging: Practical Translation Considerations Langmuir : the ACS Journal of Surfaces and Colloids. 08, 2019 | Pubmed ID: 30509068 Ultrasound Molecular Imaging for Differentiation of Benign and Malignant Tumors in Patients Quantitative Imaging in Medicine and Surgery. Dec, 2018 | Pubmed ID: 30701161 Changes in Cell Fate Determine the Regenerative and Functional Capacity of the Developing Kidney Before and After Release of Obstruction Clinical Science (London, England : 1979). 12, 2018 | Pubmed ID: 30442812 A Flow Focusing Microfluidic Device with an Integrated Coulter Particle Counter for Production, Counting and Size Characterization of Monodisperse Microbubbles Lab on a Chip. 08, 2018 | Pubmed ID: 30070301 Plectin-targeted Liposomes Enhance the Therapeutic Efficacy of a PARP Inhibitor in the Treatment of Ovarian Cancer Theranostics. 2018 | Pubmed ID: 29774075 Klf4 Has an Unexpected Protective Role in Perivascular Cells Within the Microvasculature American Journal of Physiology. Heart and Circulatory Physiology. 08, 2018 | Pubmed ID: 29631369 Targeting of Microbubbles: Contrast Agents for Ultrasound Molecular Imaging Journal of Drug Targeting. Jun - Jul, 2018 | Pubmed ID: 29258335 In Vitro Sonothrombolysis Enhancement by Transiently Stable Microbubbles Produced by a Flow-Focusing Microfluidic Device Annals of Biomedical Engineering. Feb, 2018 | Pubmed ID: 29192346 Muscle-derived Extracellular Superoxide Dismutase Inhibits Endothelial Activation and Protects Against Multiple Organ Dysfunction Syndrome in Mice Free Radical Biology & Medicine. 12, 2017 | Pubmed ID: 28982599 Evaluation of Pharmacokinetic and Pharmacodynamic Profiles of Liposomes for the Cell Type-specific Delivery of Small Molecule Drugs Nanomedicine : Nanotechnology, Biology, and Medicine. Nov, 2017 | Pubmed ID: 28754465 Focal Areas of Increased Lipid Concentration on the Coating of Microbubbles During Short Tone-burst Ultrasound Insonification PloS One. 2017 | Pubmed ID: 28686673 Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson's Disease Model Nano Letters. 06, 2017 | Pubmed ID: 28511006 Ultrasound Molecular Imaging of Inflammation in Mouse Abdominal Aorta Investigative Radiology. 09, 2017 | Pubmed ID: 28430714 Renal Collectrin Protects Against Salt-Sensitive Hypertension and Is Downregulated by Angiotensin II Journal of the American Society of Nephrology : JASN. Jun, 2017 | Pubmed ID: 28062568 The Use of Acoustic Radiation Force Decorrelation-Weighted Pulse Inversion for Enhanced Ultrasound Contrast Imaging Investigative Radiology. 02, 2017 | Pubmed ID: 27495188 Macrophages Redirect Phagocytosis by Non-professional Phagocytes and Influence Inflammation Nature. 11, 2016 | Pubmed ID: 27820945 Ultra-Low-Dose Ultrasound Molecular Imaging for the Detection of Angiogenesis in a Mouse Murine Tumor Model: How Little Can We See? Investigative Radiology. 12, 2016 | Pubmed ID: 27654582 Non-Invasive, Focal Disconnection of Brain Circuitry Using Magnetic Resonance-Guided Low-Intensity Focused Ultrasound to Deliver a Neurotoxin Ultrasound in Medicine & Biology. 09, 2016 | Pubmed ID: 27260243 Microglial Cells Prevent Hemorrhage in Neonatal Focal Arterial Stroke The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2016 | Pubmed ID: 26961944 Targeted Gene Transfer to the Brain Via the Delivery of Brain-penetrating DNA Nanoparticles with Focused Ultrasound Journal of Controlled Release : Official Journal of the Controlled Release Society. Feb, 2016 | Pubmed ID: 26732553 Synthesis and Testing of Modular Dual-Modality Nanoparticles for Magnetic Resonance and Multispectral Photoacoustic Imaging Bioconjugate Chemistry. Feb, 2016 | Pubmed ID: 26603129 Co-administration of Microbubbles and Drugs in Ultrasound-Assisted Drug Delivery: Comparison with Drug-Carrying Particles Advances in Experimental Medicine and Biology. 2016 | Pubmed ID: 26486340 Size Exclusion HPLC Detection of Small-Size Impurities As a Complementary Means for Quality Analysis of Extracellular Vesicles Journal of Circulating Biomarkers. Jan-Dec, 2015 | Pubmed ID: 28936242 Regulation of L-selectin-dependent Hydrodynamic Shear Thresholding by Leukocyte Deformability and Shear Dependent Bond Number Biorheology. 2015 | Pubmed ID: 26600268 Ultrasound in Radiology: From Anatomic, Functional, Molecular Imaging to Drug Delivery and Image-Guided Therapy Investigative Radiology. Sep, 2015 | Pubmed ID: 26200224 Optical Verification of Microbubble Response to Acoustic Radiation Force in Large Vessels With In Vivo Results Investigative Radiology. Nov, 2015 | Pubmed ID: 26135018 Development of Target-specific Liposomes for Delivering Small Molecule Drugs After Reperfused Myocardial Infarction Journal of Controlled Release : Official Journal of the Controlled Release Society. Dec, 2015 | Pubmed ID: 26122651 Therapy of Prostate Cancer Using a Novel Cancer Terminator Virus and a Small Molecule BH-3 Mimetic Oncotarget. May, 2015 | Pubmed ID: 25926554 Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli Immunity. Apr, 2015 | Pubmed ID: 25902482 Reducing Neointima Formation in a Swine Model with IVUS and Sirolimus Microbubbles Annals of Biomedical Engineering. Nov, 2015 | Pubmed ID: 25893508 Oscillatory Dynamics and In Vivo Photoacoustic Imaging Performance of Plasmonic Nanoparticle-Coated Microbubbles Small (Weinheim an Der Bergstrasse, Germany). Jul, 2015 | Pubmed ID: 25703465 In Vivo Imaging of Microfluidic-produced Microbubbles Biomedical Microdevices. Feb, 2015 | Pubmed ID: 25663444 Ultrasound-based Measurement of Molecular Marker Concentration in Large Blood Vessels: a Feasibility Study Ultrasound in Medicine & Biology. Jan, 2015 | Pubmed ID: 25308943 The Local Effects of Ovarian Diathermy in an Ovine Model of Polycystic Ovary Syndrome PloS One. 2014 | Pubmed ID: 25343339 Localized in Vivo Model Drug Delivery with Intravascular Ultrasound and Microbubbles Ultrasound in Medicine & Biology. Oct, 2014 | Pubmed ID: 25130449 Non-invasive Delivery of Stealth, Brain-penetrating Nanoparticles Across the Blood-brain Barrier Using MRI-guided Focused Ultrasound Journal of Controlled Release : Official Journal of the Controlled Release Society. Sep, 2014 | Pubmed ID: 24979210 Imaging Flow Cytometry Elucidates Limitations of Microparticle Analysis by Conventional Flow Cytometry Cytometry. Part A : the Journal of the International Society for Analytical Cytology. Sep, 2014 | Pubmed ID: 24903900 Nucleic Acid Delivery with Microbubbles and Ultrasound Advanced Drug Delivery Reviews. Jun, 2014 | Pubmed ID: 24486388 Binding Dynamics of Targeted Microbubbles in Response to Modulated Acoustic Radiation Force Physics in Medicine and Biology. Jan, 2014 | Pubmed ID: 24374866 Synthesis and Characterization of Transiently Stable Albumin-coated Microbubbles Via a Flow-focusing Microfluidic Device Ultrasound in Medicine & Biology. Feb, 2014 | Pubmed ID: 24342914 Shear Forces from Flow Are Responsible for a Distinct Statistical Signature of Adherent Microbubbles in Large Vessels Molecular Imaging. Sep, 2013 | Pubmed ID: 23981785 Ultrasound Contrast Materials in Cardiovascular Medicine: from Perfusion Assessment to Molecular Imaging Journal of Cardiovascular Translational Research. Oct, 2013 | Pubmed ID: 23913363 Ultrasound Prevents Renal Ischemia-reperfusion Injury by Stimulating the Splenic Cholinergic Anti-inflammatory Pathway Journal of the American Society of Nephrology : JASN. Sep, 2013 | Pubmed ID: 23907510 Phosphatidylserine Receptor BAI1 and Apoptotic Cells As New Promoters of Myoblast Fusion Nature. May, 2013 | Pubmed ID: 23615608 Ultrasound-based Molecular Imaging and Specific Gene Delivery to Mesenteric Vasculature by Endothelial Adhesion Molecule Targeted Microbubbles in a Mouse Model of Crohn's Disease Journal of Controlled Release : Official Journal of the Controlled Release Society. Feb, 2013 | Pubmed ID: 23142578 Ultrasound-mediated Vascular Gene Transfection by Cavitation of Endothelial-targeted Cationic Microbubbles JACC. Cardiovascular Imaging. Dec, 2012 | Pubmed ID: 23236976 Intravascular Ultrasound Catheter to Enhance Microbubble-based Drug Delivery Via Acoustic Radiation Force IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. Oct, 2012 | Pubmed ID: 23143566 Microbubbles As Ultrasound Contrast Agents for Molecular Imaging: Preparation and Application AJR. American Journal of Roentgenology. Aug, 2012 | Pubmed ID: 22826389 Markedly Enhanced Skeletal Muscle Transfection Achieved by the Ultrasound-targeted Delivery of Non-viral Gene Nanocarriers with Microbubbles Journal of Controlled Release : Official Journal of the Controlled Release Society. Sep, 2012 | Pubmed ID: 22800583 Monocyte And/or Macrophage Infiltration of Heart After Myocardial Infarction: MR Imaging by Using T1-shortening Liposomes Radiology. Aug, 2012 | Pubmed ID: 22723500 Nanobody-coupled Microbubbles As Novel Molecular Tracer Journal of Controlled Release : Official Journal of the Controlled Release Society. Mar, 2012 | Pubmed ID: 22197777 Inhibitor of Differentiation-3 Mediates High Fat Diet-induced Visceral Fat Expansion Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2012 | Pubmed ID: 22075252 Focused Ultrasound-mediated Drug Delivery from Microbubbles Reduces Drug Dose Necessary for Therapeutic Effect on Neointima Formation--brief Report Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2011 | Pubmed ID: 21960561 Phagocytic Activity of Neuronal Progenitors Regulates Adult Neurogenesis Nature Cell Biology. Jul, 2011 | Pubmed ID: 21804544 Localized Ultrasound Enhances Delivery of Rapamycin from Microbubbles to Prevent Smooth Muscle Proliferation Journal of Controlled Release : Official Journal of the Controlled Release Society. Aug, 2011 | Pubmed ID: 21549778 Real-time Technique for Improving Molecular Imaging and Guiding Drug Delivery in Large Blood Vessels: in Vitro and Ex Vivo Results Molecular Imaging. Aug, 2011 | Pubmed ID: 21521555 Inhibition of Glioma Growth by Microbubble Activation in a Subcutaneous Model Using Low Duty Cycle Ultrasound Without Significant Heating Journal of Neurosurgery. Jun, 2011 | Pubmed ID: 21214331 An Ultrasound Contrast Agent Targeted to P-selectin Detects Activated Platelets at Supra-arterial Shear Flow Conditions Investigative Radiology. Oct, 2010 | Pubmed ID: 20808239 Analysis of in Vitro Transfection by Sonoporation Using Cationic and Neutral Microbubbles Ultrasound in Medicine & Biology. Nov, 2010 | Pubmed ID: 20800945 Targeted Gene Transfection from Microbubbles into Vascular Smooth Muscle Cells Using Focused, Ultrasound-mediated Delivery Ultrasound in Medicine & Biology. Sep, 2010 | Pubmed ID: 20800174 Ultrasound-triggered Release of Materials Entrapped in Microbubble-liposome Constructs: a Tool for Targeted Drug Delivery Journal of Controlled Release : Official Journal of the Controlled Release Society. Nov, 2010 | Pubmed ID: 20691227 Molecular Imaging of Atherosclerotic Plaques Targeted to Oxidized LDL Receptor LOX-1 by SPECT/CT and Magnetic Resonance Circulation. Cardiovascular Imaging. Jul, 2010 | Pubmed ID: 20442371 Focused in Vivo Delivery of Plasmid DNA to the Porcine Vascular Wall Via Intravascular Ultrasound Destruction of Microbubbles Journal of Vascular Research. 2010 | Pubmed ID: 19923850 Dual Frequency Method for Simultaneous Translation and Real-time Imaging of Ultrasound Contrast Agents Within Large Blood Vessels Ultrasound in Medicine & Biology. Dec, 2009 | Pubmed ID: 19828229 Muscle Contraction, but Not Insulin, Increases Microvascular Blood Volume in the Presence of Free Fatty Acid-induced Insulin Resistance Diabetes. Nov, 2009 | Pubmed ID: 19675134 Action at a Distance: Lengthening Adhesion Bonds with Poly(ethylene Glycol) Spacers Enhances Mechanically Stressed Affinity for Improved Vascular Targeting of Microparticles Langmuir : the ACS Journal of Surfaces and Colloids. Sep, 2009 | Pubmed ID: 19621909 Preparation of Targeted Microbubbles: Ultrasound Contrast Agents for Molecular Imaging Medical & Biological Engineering & Computing. Aug, 2009 | Pubmed ID: 19517153 Targeted Delivery of Nanoparticles Bearing Fibroblast Growth Factor-2 by Ultrasonic Microbubble Destruction for Therapeutic Arteriogenesis Small (Weinheim an Der Bergstrasse, Germany). Oct, 2008 | Pubmed ID: 18720443 Microbubbles in Ultrasound-triggered Drug and Gene Delivery Advanced Drug Delivery Reviews. Jun, 2008 | Pubmed ID: 18486268 Acoustic Attenuation by Contrast Agent Microbubbles in Superficial Tissue Markedly Diminishes Petechiae Bioeffects in Deep Tissue Investigative Radiology. May, 2008 | Pubmed ID: 18424953 Ultrasonic Microbubble Destruction Stimulates Therapeutic Arteriogenesis Via the CD18-dependent Recruitment of Bone Marrow-derived Cells Arteriosclerosis, Thrombosis, and Vascular Biology. Jun, 2008 | Pubmed ID: 18403725 Ultrasound Molecular Imaging with Targeted Microbubble Contrast Agents Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology. Nov-Dec, 2007 | Pubmed ID: 18022115 BAI1 is an Engulfment Receptor for Apoptotic Cells Upstream of the ELMO/Dock180/Rac Module Nature. Nov, 2007 | Pubmed ID: 17960134 Enhanced Targeting of Ultrasound Contrast Agents Using Acoustic Radiation Force Ultrasound in Medicine & Biology. Jul, 2007 | Pubmed ID: 17445966 Microparticle Adhesive Dynamics and Rolling Mediated by Selectin-specific Antibodies Under Flow Biotechnology and Bioengineering. Feb, 2007 | Pubmed ID: 16917925 Targeted Ultrasound Contrast Agent for Molecular Imaging of Inflammation in High-shear Flow Contrast Media & Molecular Imaging. Nov-Dec, 2006 | Pubmed ID: 17191766 Effect of Microbubble Ligation to Cells on Ultrasound Signal Enhancement: Implications for Targeted Imaging Investigative Radiology. Oct, 2006 | Pubmed ID: 16971795 Deformable Gas-filled Microbubbles Targeted to P-selectin Journal of Controlled Release : Official Journal of the Controlled Release Society. Sep, 2006 | Pubmed ID: 16887229 3D Perfusion Mapping in Post-infarct Mice Using Myocardial Contrast Echocardiography Ultrasound in Medicine & Biology. Jun, 2006 | Pubmed ID: 16785003 Microbubble Contrast Agents: Targeted Ultrasound Imaging and Ultrasound-assisted Drug-delivery Applications Investigative Radiology. Mar, 2006 | Pubmed ID: 16481920 Targeting Mucosal Addressin Cellular Adhesion Molecule (MAdCAM)-1 to Noninvasively Image Experimental Crohn's Disease Gastroenterology. Jan, 2006 | Pubmed ID: 16401463 Ultrasound-microbubble-induced Neovascularization in Mouse Skeletal Muscle Ultrasound in Medicine & Biology. Oct, 2005 | Pubmed ID: 16223645 Assessment of Endogenous and Therapeutic Arteriogenesis by Contrast Ultrasound Molecular Imaging of Integrin Expression Circulation. Jun, 2005 | Pubmed ID: 15956135 Simultaneous Integrin Alphavbeta3 and Glycoprotein IIb/IIIa Inhibition Causes Reduction in Infarct Size in a Model of Acute Coronary Thrombosis and Primary Angioplasty Cardiovascular Research. Jun, 2005 | Pubmed ID: 15914120 Acoustic Radiation Force Enhances Targeted Delivery of Ultrasound Contrast Microbubbles: in Vitro Verification IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. Mar, 2005 | Pubmed ID: 15857050 Ligand-carrying Gas-filled Microbubbles: Ultrasound Contrast Agents for Targeted Molecular Imaging Bioconjugate Chemistry. Jan-Feb, 2005 | Pubmed ID: 15656569 Molecular Imaging with Targeted Ultrasound Contrast Microbubbles Ernst Schering Research Foundation Workshop. 2005 | Pubmed ID: 15524217 Microvascular Recruitment is an Early Insulin Effect That Regulates Skeletal Muscle Glucose Uptake in Vivo Diabetes. Jun, 2004 | Pubmed ID: 15161743 Binding and Detachment Dynamics of Microbubbles Targeted to P-selectin Under Controlled Shear Flow Journal of Controlled Release : Official Journal of the Controlled Release Society. May, 2004 | Pubmed ID: 15120903 Detection of Individual Microbubbles of Ultrasound Contrast Agents: Imaging of Free-floating and Targeted Bubbles Investigative Radiology. Mar, 2004 | Pubmed ID: 15076011 Targeted Tissue Transfection with Ultrasound Destruction of Plasmid-bearing Cationic Microbubbles Ultrasound in Medicine & Biology. Dec, 2003 | Pubmed ID: 14698343 Imaging Tumor Angiogenesis with Contrast Ultrasound and Microbubbles Targeted to Alpha(v)beta3 Circulation. Jul, 2003 | Pubmed ID: 12835208 Noninvasive Assessment of Angiogenesis by Ultrasound and Microbubbles Targeted to Alpha(v)-integrins Circulation. Jan, 2003 | Pubmed ID: 12551871 Detection of Individual Microbubbles of an Ultrasound Contrast Agent: Fundamental and Pulse Inversion Imaging Academic Radiology. Aug, 2002 | Pubmed ID: 12188248 Noninvasive Imaging of Myocardial Reperfusion Injury Using Leukocyte-targeted Contrast Echocardiography Circulation. Apr, 2002 | Pubmed ID: 11956115 Preparação, Administração e Avaliação da Captação Celular Tecido-Específica In Vivo de Lipossomas Marcados com Corante Fluorescente Victoria Osinski1,2, Alexander L Klibanov1,3, Coleen A McNamara1,3 1Robert M. Berne Cardiovascular Research Center, University of Virginia, 2Department of Pathology, University of Virginia, 3Department of Medicine, Division of Cardiovascular Medicine, University of Virginia JoVE 61585 Bioengenharia
Preparação, Administração e Avaliação da Captação Celular Tecido-Específica In Vivo de Lipossomas Marcados com Corante Fluorescente Victoria Osinski1,2, Alexander L Klibanov1,3, Coleen A McNamara1,3 1Robert M. Berne Cardiovascular Research Center, University of Virginia, 2Department of Pathology, University of Virginia, 3Department of Medicine, Division of Cardiovascular Medicine, University of Virginia JoVE 61585 Bioengenharia