Andrew Worth Centers for Cancer Pharmacology and Excellence in Environmental Toxicology, Department of Pharmacology University of Pennsylvania Biography Publications Institution JoVE Articles Andrew Worth has not added a biography. If you are Andrew Worth and would like to personalize this page please email our Author Liaison for assistance. Publications Accelerated In Vivo Proliferation of Memory Phenotype CD4(+) T-cells in Human HIV-1 Infection Irrespective of Viral Chemokine Co-receptor Tropism PLoS Pathogens. Apr, 2013 | Pubmed ID: 23637601 QSAR and Metabolic Assessment Tools in the Assessment of Genotoxicity Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23086840 Training Needs for Toxicity Testing in the 21st Century: a Survey-informed Analysis Alternatives to Laboratory Animals : ATLA. Dec, 2012 | Pubmed ID: 23398336 Applying Quantitative Structure-activity Relationship Approaches to Nanotoxicology: Current Status and Future Potential Toxicology. Nov, 2012 | Pubmed ID: 23165187 Report of the EPAA-ECVAM Workshop on the Validation of Integrated Testing Strategies (ITS) Alternatives to Laboratory Animals : ATLA. Jul, 2012 | Pubmed ID: 22943518 Comparison Between a Novel Bovine Xenoimplant and Autogenous Cancellous Bone Graft in Tibial Tuberosity Advancement Veterinary Surgery : VS. Jul, 2012 | Pubmed ID: 22632456 Rapid Prototype Modeling and Customized Titanium Plate Fabrication for Correction of a Persistent Hard Palate Defect in a Dog Journal of the American Veterinary Medical Association. Jun, 2012 | Pubmed ID: 22607598 Recent Advances in the Molecular Modeling of Estrogen Receptor-mediated Toxicity Advances in Protein Chemistry and Structural Biology. 2011 | Pubmed ID: 21920325 A Theoretical Framework for Predicting the Oxidative Stress Potential of Oxide Nanoparticles Nanotoxicology. Jun, 2011 | Pubmed ID: 21609138 Use of Computational Tools in the Field of Food Safety Regulatory Toxicology and Pharmacology : RTP. Aug, 2011 | Pubmed ID: 21600952 Alternative (non-animal) Methods for Cosmetics Testing: Current Status and Future Prospects-2010 Archives of Toxicology. May, 2011 | Pubmed ID: 21533817 QSAR Modeling of Nanomaterials Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology. May-Jun, 2011 | Pubmed ID: 21384562 Computational Nanotoxicology: Predicting Toxicity of Nanoparticles Nature Nanotechnology. Mar, 2011 | Pubmed ID: 21372838 Characterization of Age-related Changes in Bovine CD8+ T-cells Veterinary Immunology and Immunopathology. Mar, 2011 | Pubmed ID: 21159386 Human Cytomegalovirus-specific CD8(+) T-cell Expansions Contain Long-lived Cells That Retain Functional Capacity in Both Young and Elderly Subjects Immunology. Jan, 2011 | Pubmed ID: 20738423 Mycobacterium Tuberculosis PPD-induced Immune Biomarkers Measurable in Vitro Following BCG Vaccination of UK Adolescents by Multiplex Bead Array and Intracellular Cytokine Staining BMC Immunology. 2010 | Pubmed ID: 20609237 Computational Toxicology at the European Commission's Joint Research Centre Expert Opinion on Drug Metabolism & Toxicology. Jul, 2010 | Pubmed ID: 20443752 Computational Methods to Predict the Reactivity of Nanoparticles Through Structure-property Relationships Expert Opinion on Drug Delivery. Mar, 2010 | Pubmed ID: 20201736 Structural Analysis and Predictive Value of the Rodent in Vivo Micronucleus Assay Results Mutagenesis. Jul, 2010 | Pubmed ID: 20194420 Thresholds of Toxicological Concern for Endocrine Active Substances in the Aquatic Environment Integrated Environmental Assessment and Management. Jan, 2010 | Pubmed ID: 19558199 Overcoming Barriers to Validation of Non-animal Partial Replacement Methods/Integrated Testing Strategies: the Report of an EPAA-ECVAM Workshop Alternatives to Laboratory Animals : ATLA. Sep, 2009 | Pubmed ID: 19807215 Epitope Specificity and Relative Clonal Abundance Do Not Affect CD8 Differentiation Patterns During Lymphocytic Choriomeningitis Virus Infection Journal of Virology. Nov, 2009 | Pubmed ID: 19726518 Structural Motifs Modulating the Carcinogenic Risk of Aromatic Amines Environmental and Molecular Mutagenesis. Mar, 2009 | Pubmed ID: 19152383 The Antigen-specific Memory CD8+ T-cell Response Induced by BCG in Cattle Resides in the CD8+gamma/deltaTCR-CD45RO+ T-cell Population Vaccine. Jan, 2009 | Pubmed ID: 18996428 Modeling the Structure-property Relationships of Nanoneedles: A Journey Toward Nanomedicine Journal of Computational Chemistry. Jan, 2009 | Pubmed ID: 18615420 Imaging Diagnosis--traumatic Myelopathy in a Dog with Incomplete Ossification of the Dorsal Lamina of the Atlas Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association. Nov-Dec, 2008 | Pubmed ID: 19051648 Toward in Silico Approaches for Investigating the Activity of Nanoparticles in Therapeutic Development IDrugs : the Investigational Drugs Journal. Oct, 2008 | Pubmed ID: 18828072 Toxmatch--a Chemical Classification and Activity Prediction Tool Based on Similarity Measures Regulatory Toxicology and Pharmacology : RTP. Nov, 2008 | Pubmed ID: 18617309 A Feasibility Study Developing an Integrated Testing Strategy Assessing Skin Irritation Potential of Chemicals Toxicology Letters. Jul, 2008 | Pubmed ID: 18585875 The ECVAM International Validation Study on in Vitro Tests for Acute Skin Irritation: Selection of Test Chemicals Alternatives to Laboratory Animals : ATLA. Dec, 2007 | Pubmed ID: 18186668 The ECVAM International Validation Study on in Vitro Tests for Acute Skin Irritation: Report on the Validity of the EPISKIN and EpiDerm Assays and on the Skin Integrity Function Test Alternatives to Laboratory Animals : ATLA. Dec, 2007 | Pubmed ID: 18186667 In Vivo T Lymphocyte Dynamics in Humans and the Impact of Human T-lymphotropic Virus 1 Infection Proceedings of the National Academy of Sciences of the United States of America. May, 2007 | Pubmed ID: 17483473 In Vivo Kinetics of Human Natural Killer Cells: the Effects of Ageing and Acute and Chronic Viral Infection Immunology. Jun, 2007 | Pubmed ID: 17346281 Model-based Variational Smoothing and Segmentation for Diffusion Tensor Imaging in the Brain Neuroinformatics. 2006 | Pubmed ID: 16943628 Quantitative Structure-activity-activity and Quantitative Structure-activity Investigations of Human and Rodent Toxicity Chemosphere. Dec, 2006 | Pubmed ID: 16714047 Comparison of the Applicability Domain of a Quantitative Structure-activity Relationship for Estrogenicity with a Large Chemical Inventory Environmental Toxicology and Chemistry / SETAC. May, 2006 | Pubmed ID: 16704052 Metabolism: a Bottleneck in in Vitro Toxicological Test Development. The Report and Recommendations of ECVAM Workshop 54 Alternatives to Laboratory Animals : ATLA. Feb, 2006 | Pubmed ID: 16522150 Skin Sensitisation Alternatives to Laboratory Animals : ATLA. Jul, 2005 | Pubmed ID: 16194142 Eye Irritation Alternatives to Laboratory Animals : ATLA. Jul, 2005 | Pubmed ID: 16194141 Current Status of Methods for Defining the Applicability Domain of (quantitative) Structure-activity Relationships. The Report and Recommendations of ECVAM Workshop 52 Alternatives to Laboratory Animals : ATLA. Apr, 2005 | Pubmed ID: 16180989 Shared Alterations in NK Cell Frequency, Phenotype, and Function in Chronic Human Immunodeficiency Virus and Hepatitis C Virus Infections Journal of Virology. Oct, 2005 | Pubmed ID: 16160163 The Evaluation of Processed Cancellous Bovine Bone As a Bone Graft Substitute Clinical Oral Implants Research. Jun, 2005 | Pubmed ID: 15877759 B-cell Kinetics in Humans: Rapid Turnover of Peripheral Blood Memory Cells Blood. May, 2005 | Pubmed ID: 15644412 Report of the Workshop on the Validation of QSARs and Other Computational Prediction Models Alternatives to Laboratory Animals : ATLA. Jun, 2004 | Pubmed ID: 23581163 The Principles of Validation and the ECVAM Validation Process Alternatives to Laboratory Animals : ATLA. Jun, 2004 | Pubmed ID: 23581150 A Modular Approach to the ECVAM Principles on Test Validity Alternatives to Laboratory Animals : ATLA. Nov, 2004 | Pubmed ID: 15656771 Direct Measurement of T Cell Subset Kinetics in Vivo in Elderly Men and Women Journal of Immunology (Baltimore, Md. : 1950). Aug, 2004 | Pubmed ID: 15265909 Rapid Turnover of Effector-memory CD4(+) T Cells in Healthy Humans The Journal of Experimental Medicine. Jul, 2004 | Pubmed ID: 15249595 ECVAM's Response to the Changing Political Environment for Alternatives: Consequences of the European Union Chemicals and Cosmetics Policies Alternatives to Laboratory Animals : ATLA. Nov, 2003 | Pubmed ID: 15598174 Rapid Turnover of T Cells in Acute Infectious Mononucleosis European Journal of Immunology. Oct, 2003 | Pubmed ID: 14515249 Quantitative Structure-activity Relationships for Human Health Effects: Commonalities with Other Endpoints Environmental Toxicology and Chemistry / SETAC. Aug, 2003 | Pubmed ID: 12924582 Use of QSARs in International Decision-making Frameworks to Predict Health Effects of Chemical Substances Environmental Health Perspectives. Aug, 2003 | Pubmed ID: 12896862 Use of QSARs in International Decision-making Frameworks to Predict Ecologic Effects and Environmental Fate of Chemical Substances Environmental Health Perspectives. Aug, 2003 | Pubmed ID: 12896861 Methods for Reliability and Uncertainty Assessment and for Applicability Evaluations of Classification- and Regression-based QSARs Environmental Health Perspectives. Aug, 2003 | Pubmed ID: 12896860 Measurement and Modeling of Human T Cell Kinetics European Journal of Immunology. Aug, 2003 | Pubmed ID: 12884307 Functional MRI Activity Characterization Using Response Time Shift Estimates from Curve Evolution IEEE Transactions on Medical Imaging. Nov, 2002 | Pubmed ID: 12575877 ECVAM's Activities on Computer Modelling and Integrated Testing Alternatives to Laboratory Animals : ATLA. Dec, 2002 | Pubmed ID: 12513665 The Principles of Validation and the ECVAM Validation Process Alternatives to Laboratory Animals : ATLA. Dec, 2002 | Pubmed ID: 12513647 Structure-based Classification of Antibacterial Activity Journal of Chemical Information and Computer Sciences. Jul-Aug, 2002 | Pubmed ID: 12132888 Follow-up to the ECVAM Prevalidation Study on in Vitro Tests for Acute Skin Irritation. The European Centre for the Validation of Alternative Methods Skin Irritation Task Force Report 2 Alternatives to Laboratory Animals : ATLA. Jan-Feb, 2002 | Pubmed ID: 11827575 Untargeted Metabolomics from Biological Sources Using Ultraperformance Liquid Chromatography-High Resolution Mass Spectrometry (UPLC-HRMS) Nathaniel W. Snyder1, Maya Khezam1, Clementina A. Mesaros1, Andrew Worth1, Ian A. Blair1 1Centers for Cancer Pharmacology and Excellence in Environmental Toxicology, Department of Pharmacology, University of Pennsylvania JoVE 50433 Química
Untargeted Metabolomics from Biological Sources Using Ultraperformance Liquid Chromatography-High Resolution Mass Spectrometry (UPLC-HRMS) Nathaniel W. Snyder1, Maya Khezam1, Clementina A. Mesaros1, Andrew Worth1, Ian A. Blair1 1Centers for Cancer Pharmacology and Excellence in Environmental Toxicology, Department of Pharmacology, University of Pennsylvania JoVE 50433 Química