Anthony J. Koleske Department of Molecular Biophysics and Biochemistry Yale University Biography Publications Institution JoVE Articles Anthony J. Koleske has not added a biography. If you are Anthony J. Koleske and would like to personalize this page please email our Author Liaison for assistance. Publications Platelet-derived Growth Factor Receptor Beta Activates Abl2 Via Direct Binding and Phosphorylation The Journal of Biological Chemistry. 07, 2021 | Pubmed ID: 34144039 Regulation of the NMDA Receptor by Its Cytoplasmic Domains: (How) is the Tail Wagging the Dog? Neuropharmacology. 09, 2021 | Pubmed ID: 34097949 Abl2:Cortactin Interactions Regulate Dendritic Spine Stability Via Control of a Stable Filamentous Actin Pool The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 04, 2021 | Pubmed ID: 33622779 Trio Family Proteins As Regulators of Cell Migration and Morphogenesis in Development and Disease - Mechanisms and Cellular Contexts Journal of Cell Science. 02, 2021 | Pubmed ID: 33568469 Functional Interactions of Ion Channels with the Actin Cytoskeleton: Does Coupling to Dynamic Actin Regulate NMDA Receptors? The Journal of Physiology. 01, 2021 | Pubmed ID: 32034761 Crystal Structure of a Guanine Nucleotide Exchange Factor Encoded by the Scrub Typhus Pathogen Proceedings of the National Academy of Sciences of the United States of America. 12, 2020 | Pubmed ID: 33184172 Two-color Nanoscopy of Organelles for Extended Times with HIDE Probes Nature Communications. 08, 2020 | Pubmed ID: 32848153 Neural Stem Cells Direct Axon Guidance Via Their Radial Fiber Scaffold Neuron. 09, 2020 | Pubmed ID: 32707082 ABL1, Overexpressed in Hepatocellular Carcinomas, Regulates Expression of NOTCH1 and Promotes Development of Liver Tumors in Mice Gastroenterology. 07, 2020 | Pubmed ID: 32171747 Regulation of MT Dynamics Via Direct Binding of an Abl Family Kinase The Journal of Cell Biology. 12, 2019 | Pubmed ID: 31699690 Integrin α5β1 Regulates PP2A Complex Assembly Through PDE4D in Atherosclerosis The Journal of Clinical Investigation. 08, 2019 | Pubmed ID: 31408443 Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits Cell Reports. 03, 2019 | Pubmed ID: 30840899 Transient Inhibition of P53 Homologs Protects Ovarian Function from Two Distinct Apoptotic Pathways Triggered by Anticancer Therapies Cell Death and Differentiation. 03, 2019 | Pubmed ID: 29988075 Abl2 is Recruited to Ventral Actin Waves Through Cytoskeletal Interactions to Promote Lamellipodium Extension Molecular Biology of the Cell. 11, 2018 | Pubmed ID: 30256707 Noonan Syndrome-Associated SHP2 Dephosphorylates GluN2B to Regulate NMDA Receptor Function Cell Reports. 08, 2018 | Pubmed ID: 30089263 Cortactin Stabilization of Actin Requires Actin-binding Repeats and Linker, is Disrupted by Specific Substitutions, and is Independent of Nucleotide State The Journal of Biological Chemistry. 08, 2018 | Pubmed ID: 29929984 A Role for the Non-Receptor Tyrosine Kinase Abl2/Arg in Experimental Neuroinflammation Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. 06, 2018 | Pubmed ID: 29550892 Analysis of Cellular Tyrosine Phosphorylation Via Chemical Rescue of Conditionally Active Abl Kinase Biochemistry. 02, 2018 | Pubmed ID: 29341593 The Vascular Endothelial Specific IL-4 Receptor Alpha-ABL1 Kinase Signaling Axis Regulates the Severity of IgE-mediated Anaphylactic Reactions The Journal of Allergy and Clinical Immunology. 10, 2018 | Pubmed ID: 29157947 The Repeat Region of Cortactin is Intrinsically Disordered in Solution Scientific Reports. 12, 2017 | Pubmed ID: 29196701 Corticosteroid-induced Dendrite Loss and Behavioral Deficiencies Can Be Blocked by Activation of Abl2/Arg Kinase Molecular and Cellular Neurosciences. 12, 2017 | Pubmed ID: 29107098 CNS Neurons Deposit Laminin α5 to Stabilize Synapses Cell Reports. Oct, 2017 | Pubmed ID: 29091766 Neurodevelopmental Disease-associated De Novo Mutations and Rare Sequence Variants Affect TRIO GDP/GTP Exchange Factor Activity Human Molecular Genetics. 12, 2017 | Pubmed ID: 28973398 Long-Term Live-Cell STED Nanoscopy of Primary and Cultured Cells with the Plasma Membrane HIDE Probe DiI-SiR Angewandte Chemie (International Ed. in English). 08, 2017 | Pubmed ID: 28679029 Brain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity ACS Chemical Neuroscience. 07, 2017 | Pubmed ID: 28418645 Phosphorylated Cortactin Recruits Vav2 Guanine Nucleotide Exchange Factor to Activate Rac3 and Promote Invadopodial Function in Invasive Breast Cancer Cells Molecular Biology of the Cell. May, 2017 | Pubmed ID: 28356423 Differential Expression of Cytoskeletal Regulatory Factors in the Adolescent Prefrontal Cortex: Implications for Cortical Development Journal of Neuroscience Research. 05, 2017 | Pubmed ID: 27735056 Arg Deficiency Does Not Influence the Course of Myelin Oligodendrocyte Glycoprotein (MOG35-55)-induced Experimental Autoimmune Encephalomyelitis Journal of Clinical & Cellular Immunology. 2016 | Pubmed ID: 34527426 Reciprocal Stabilization of ABL and TAZ Regulates Osteoblastogenesis Through Transcription Factor RUNX2 The Journal of Clinical Investigation. Dec, 2016 | Pubmed ID: 27797343 The Src Kinases Hck, Fgr and Lyn Activate Arg to Facilitate IgG-mediated Phagocytosis and Leishmania Infection Journal of Cell Science. 08, 2016 | Pubmed ID: 27358479 Disruption of Coordinated Presynaptic and Postsynaptic Maturation Underlies the Defects in Hippocampal Synapse Stability and Plasticity in Abl2/Arg-Deficient Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 06, 2016 | Pubmed ID: 27335408 SNARE Complex Dysfunction: A Unifying Hypothesis for Schizophrenia Biological Psychiatry. Sep, 2015 | Pubmed ID: 26296424 A Phase Ib Multiple Ascending Dose Study of the Safety, Tolerability, and Central Nervous System Availability of AZD0530 (saracatinib) in Alzheimer's Disease Alzheimer's Research & Therapy. 2015 | Pubmed ID: 25874001 Structure of the ABL2/ARG Kinase in Complex with Dasatinib Acta Crystallographica. Section F, Structural Biology Communications. Apr, 2015 | Pubmed ID: 25849507 Direct Interactions with the Integrin β1 Cytoplasmic Tail Activate the Abl2/Arg Kinase The Journal of Biological Chemistry. Mar, 2015 | Pubmed ID: 25694433 Abl2/Abl-related Gene Stabilizes Actin Filaments, Stimulates Actin Branching by Actin-related Protein 2/3 Complex, and Promotes Actin Filament Severing by Cofilin The Journal of Biological Chemistry. Feb, 2015 | Pubmed ID: 25540195 Adolescent Cocaine Exposure Simplifies Orbitofrontal Cortical Dendritic Arbors Frontiers in Pharmacology. 2014 | Pubmed ID: 25452728 ECM Receptors in Neuronal Structure, Synaptic Plasticity, and Behavior Progress in Brain Research. 2014 | Pubmed ID: 25410355 Extracellular Matrix Control of Dendritic Spine and Synapse Structure and Plasticity in Adulthood Frontiers in Neuroanatomy. 2014 | Pubmed ID: 25368556 Two Amino Acid Residues Confer Different Binding Affinities of Abelson Family Kinase SRC Homology 2 Domains for Phosphorylated Cortactin The Journal of Biological Chemistry. Jul, 2014 | Pubmed ID: 24891505 Ablation of ErbB4 from Excitatory Neurons Leads to Reduced Dendritic Spine Density in Mouse Prefrontal Cortex The Journal of Comparative Neurology. Oct, 2014 | Pubmed ID: 24752666 Metabotropic Glutamate Receptor 5 is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein Neuron. Sep, 2013 | Pubmed ID: 24012003 Arg Kinase Signaling in Dendrite and Synapse Stabilization Pathways: Memory, Cocaine Sensitivity, and Stress The International Journal of Biochemistry & Cell Biology. Nov, 2013 | Pubmed ID: 23916785 Molecular Mechanisms of Dendrite Stability Nature Reviews. Neuroscience. Aug, 2013 | Pubmed ID: 23839597 WAVE2 Regulates Epithelial Morphology and Cadherin Isoform Switching Through Regulation of Twist and Abl PloS One. 2013 | Pubmed ID: 23691243 Integrin α3 is Required for Late Postnatal Stability of Dendrite Arbors, Dendritic Spines and Synapses, and Mouse Behavior The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2013 | Pubmed ID: 23595732 β1 Integrin Regulates Arg to Promote Invadopodial Maturation and Matrix Degradation Molecular Biology of the Cell. Jun, 2013 | Pubmed ID: 23552693 Corticosteroid-induced Neural Remodeling Predicts Behavioral Vulnerability and Resilience The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2013 | Pubmed ID: 23407965 Abl2/Arg Controls Dendritic Spine and Dendrite Arbor Stability Via Distinct Cytoskeletal Control Pathways The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2013 | Pubmed ID: 23365224 Delayed Amyloid Plaque Deposition and Behavioral Deficits in Outcrossed AβPP/PS1 Mice The Journal of Comparative Neurology. Apr, 2013 | Pubmed ID: 23047754 Arg/Abl2 Promotes Invasion and Attenuates Proliferation of Breast Cancer in Vivo Oncogene. May, 2013 | Pubmed ID: 22777352 Action Control is Mediated by Prefrontal BDNF and Glucocorticoid Receptor Binding Proceedings of the National Academy of Sciences of the United States of America. Dec, 2012 | Pubmed ID: 23185000 A Peptide Photoaffinity Probe Specific for the Active Conformation of the Abl Tyrosine Kinase Chembiochem : a European Journal of Chemical Biology. Nov, 2012 | Pubmed ID: 23081945 Met Acts Through Abl to Regulate P53 Transcriptional Outcomes and Cell Survival in the Developing Liver Journal of Hepatology. Dec, 2012 | Pubmed ID: 22889954 Arg/Abl2 Modulates the Affinity and Stoichiometry of Binding of Cortactin to F-actin Biochemistry. Aug, 2012 | Pubmed ID: 22849492 The Abl and Arg Kinases Mediate Distinct Modes of Phagocytosis and Are Required for Maximal Leishmania Infection Molecular and Cellular Biology. Aug, 2012 | Pubmed ID: 22665498 Cortactin in Cell Migration and Cancer at a Glance Journal of Cell Science. Apr, 2012 | Pubmed ID: 22566665 Arg Kinase Regulates Prefrontal Dendritic Spine Refinement and Cocaine-induced Plasticity The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2012 | Pubmed ID: 22396406 Integrin β1 Signals Through Arg to Regulate Postnatal Dendritic Arborization, Synapse Density, and Behavior The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2012 | Pubmed ID: 22357865 Lysozyme Contamination Facilitates Crystallization of a Heterotrimeric Cortactin-Arg-lysozyme Complex Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Feb, 2012 | Pubmed ID: 22297987 Cortactin 인 산화 조절 PH 종속 통로 통해 셀 침공 The Journal of Cell Biology. Nov, 2011 | Pubmed ID: 22105349 ErbB4 Localization to Interneurons: Clearer Insights into Schizophrenia Pathology Biological Psychiatry. Oct, 2011 | Pubmed ID: 21924131 Invadopodia: RhoC Runs Rings Around Cofilin Current Biology : CB. Apr, 2011 | Pubmed ID: 21514509 Cell Adhesion Signaling Pathways: First Responders to Cocaine Exposure? Communicative & Integrative Biology. Jan, 2011 | Pubmed ID: 21509173 The Vacuolar-ATPase Modulates Matrix Metalloproteinase Isoforms in Human Pancreatic Cancer Laboratory Investigation; a Journal of Technical Methods and Pathology. May, 2011 | Pubmed ID: 21339745 EGFR Src Arg Cortactin 통로 기능 성숙 Invadopodia 및 유 방 암 세포 침공의 중재 Cancer Research. Mar, 2011 | Pubmed ID: 21257711 특정 티로신 인 산화 사이트 Cortactin에 Invadopodia에 Nck1 종속 말라 합 조절 Journal of Cell Science. Nov, 2010 | Pubmed ID: 20971703 Phosphorylation by the C-Abl Protein Tyrosine Kinase Inhibits Parkin's Ubiquitination and Protective Function Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010 | Pubmed ID: 20823226 The Abl and Arg Non-receptor Tyrosine Kinases Regulate Different Zones of Stress Fiber, Focal Adhesion, and Contractile Network Localization in Spreading Fibroblasts Cytoskeleton (Hoboken, N.J.). Oct, 2010 | Pubmed ID: 20737438 Increased Dendrite Branching in AbetaPP/PS1 Mice and Elongation of Dendrite Arbors by Fasudil Administration Journal of Alzheimer's Disease : JAD. 2010 | Pubmed ID: 20413901 Mechanisms of Synapse and Dendrite Maintenance and Their Disruption in Psychiatric and Neurodegenerative Disorders Annual Review of Neuroscience. 2010 | Pubmed ID: 20367247 Synaptic Clustering of PSD-95 is Regulated by C-Abl Through Tyrosine Phosphorylation The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2010 | Pubmed ID: 20220006 Regulation of Actin Polymerization and Adhesion-dependent Cell Edge Protrusion by the Abl-related Gene (Arg) Tyrosine Kinase and N-WASp Biochemistry. Mar, 2010 | Pubmed ID: 20146487 Loss of Dendrite Stabilization by the Abl-related Gene (Arg) Kinase Regulates Behavioral Flexibility and Sensitivity to Cocaine Proceedings of the National Academy of Sciences of the United States of America. Sep, 2009 | Pubmed ID: 19805386 Regulation of Cell Migration and Morphogenesis by Abl-family Kinases: Emerging Mechanisms and Physiological Contexts Journal of Cell Science. Oct, 2009 | Pubmed ID: 19759284 Cortactin Cofilin 및 Invadopodium 어셈블리와 성숙의 단계를 제어 하려면 N-말 벌 활동을 조절 The Journal of Cell Biology. Aug, 2009 | Pubmed ID: 19704022 N-myristoylated C-Abl Tyrosine Kinase Localizes to the Endoplasmic Reticulum Upon Binding to an Allosteric Inhibitor The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19679652 Arg Interacts with Cortactin to Promote Adhesion-dependent Cell Edge Protrusion The Journal of Cell Biology. May, 2009 | Pubmed ID: 19414610 T Cell Survival and Function Requires the C-Abl Tyrosine Kinase Cell Cycle (Georgetown, Tex.). Dec, 2008 | Pubmed ID: 19098427 Enhancement of ABL Kinase Catalytic Efficiency by a Direct Binding Regulator is Independent of Other Regulatory Mechanisms The Journal of Biological Chemistry. Nov, 2008 | Pubmed ID: 18796434 The C-Abl Tyrosine Kinase Regulates Actin Remodeling at the Immune Synapse Blood. Jul, 2008 | Pubmed ID: 18305217 Inhibition of Rho Via Arg and P190RhoGAP in the Postnatal Mouse Hippocampus Regulates Dendritic Spine Maturation, Synapse and Dendrite Stability, and Behavior The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2007 | Pubmed ID: 17928439 Use of a Chemical Genetic Technique to Identify Myosin IIb As a Substrate of the Abl-related Gene (Arg) Tyrosine Kinase Biochemistry. Oct, 2007 | Pubmed ID: 17892306 Dissecting Kinase Signaling Pathways Drug Discovery Today. Sep, 2007 | Pubmed ID: 17826684 The Abl-related Gene Tyrosine Kinase Acts Through P190RhoGAP to Inhibit Actomyosin Contractility and Regulate Focal Adhesion Dynamics Upon Adhesion to Fibronectin Molecular Biology of the Cell. Oct, 2007 | Pubmed ID: 17652459 A Critical Role for Cortactin Phosphorylation by Abl-family Kinases in PDGF-induced Dorsal-wave Formation Current Biology : CB. Mar, 2007 | Pubmed ID: 17306540 Integrin Signaling Through Arg Activates P190RhoGAP by Promoting Its Binding to P120RasGAP and Recruitment to the Membrane Molecular Biology of the Cell. Nov, 2006 | Pubmed ID: 16971514 Integrin-mediated Dendrite Branch Maintenance Requires Abelson (Abl) Family Kinases The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2005 | Pubmed ID: 15987940 The Abl-related Gene (Arg) Requires Its F-actin-microtubule Cross-linking Activity to Regulate Lamellipodial Dynamics During Fibroblast Adhesion The Journal of Cell Biology. May, 2004 | Pubmed ID: 15138293 Adhesion-dependent Regulation of P190RhoGAP in the Developing Brain by the Abl-related Gene Tyrosine Kinase Current Biology : CB. Apr, 2004 | Pubmed ID: 15084284 Bidirectional Signaling Links the Abelson Kinases to the Platelet-derived Growth Factor Receptor Molecular and Cellular Biology. Mar, 2004 | Pubmed ID: 14993293 How Do Abl Family Kinases Regulate Cell Shape and Movement? Trends in Cell Biology. Jan, 2004 | Pubmed ID: 14729179 Do Filopodia Enable the Growth Cone to Find Its Way? Science's STKE : Signal Transduction Knowledge Environment. May, 2003 | Pubmed ID: 12759482 Two Distinct Phosphorylation Pathways Have Additive Effects on Abl Family Kinase Activation Molecular and Cellular Biology. Jun, 2003 | Pubmed ID: 12748290 Abl Family Nonreceptor Tyrosine Kinases Modulate Short-term Synaptic Plasticity Journal of Neurophysiology. Mar, 2003 | Pubmed ID: 12626632 The Abl-related Gene (Arg) Nonreceptor Tyrosine Kinase Uses Two F-actin-binding Domains to Bundle F-actin Proceedings of the National Academy of Sciences of the United States of America. Dec, 2001 | Pubmed ID: 11752434 Essential Roles for the Abl and Arg Tyrosine Kinases in Neurulation Neuron. Dec, 1998 | Pubmed ID: 9883720 라이브 셀 현미경을 사용하여 확산 중 셀 에지 돌출 역학 측정 Nikola Lukic*1, Trishna Saha*1, Stefanie Lapetina1, Michal Gendler1, Gilad Lehmann1, Anthony J. Koleske2,3, Hava Gil-Henn1 1The Azrieli Faculty of Medicine, Bar-Ilan University, 2Department of Molecular Biophysics and Biochemistry, Yale University, 3Department of Neuroscience, Yale University JoVE 63157 Biologia
라이브 셀 현미경을 사용하여 확산 중 셀 에지 돌출 역학 측정 Nikola Lukic*1, Trishna Saha*1, Stefanie Lapetina1, Michal Gendler1, Gilad Lehmann1, Anthony J. Koleske2,3, Hava Gil-Henn1 1The Azrieli Faculty of Medicine, Bar-Ilan University, 2Department of Molecular Biophysics and Biochemistry, Yale University, 3Department of Neuroscience, Yale University JoVE 63157 Biologia