Bernd Schmeck Institute for Lung Research, Universities of Giessen and Marburg Lung Center Philipps-University Marburg Biography Publications Institution JoVE Articles Bernd Schmeck has not added a biography. If you are Bernd Schmeck and would like to personalize this page please email our Author Liaison for assistance. Publications An Interactive Macrophage Signal Transduction Map Facilitates Comparative Analyses of High-Throughput Data Journal of Immunology (Baltimore, Md. : 1950). Jan, 2017 | Pubmed ID: 28137890 Current Concepts in Chronic Inflammatory Diseases: Interactions Between Microbes, Cellular Metabolism, and Inflammation The Journal of Allergy and Clinical Immunology. Jul, 2016 | Pubmed ID: 27373325 Genome-wide Chromatin Profiling of Legionella Pneumophila-Infected Human Macrophages Reveals Activation of the Probacterial Host Factor TNFAIP2 The Journal of Infectious Diseases. Aug, 2016 | Pubmed ID: 27130431 Legionella Pneumophila-Derived Outer Membrane Vesicles Promote Bacterial Replication in Macrophages PLoS Pathogens. Apr, 2016 | Pubmed ID: 27105429 MicroRNAs Constitute a Negative Feedback Loop in Streptococcus Pneumoniae-Induced Macrophage Activation The Journal of Infectious Diseases. Jul, 2016 | Pubmed ID: 26984146 Annexin A1 Sustains Tumor Metabolism and Cellular Proliferation Upon Stable Loss of HIF1A Oncotarget. Feb, 2016 | Pubmed ID: 26760764 Third-Kind Encounters in Biomedicine: Immunology Meets Mathematics and Informatics to Become Quantitative and Predictive Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26677184 Systems Medicine for Lung Diseases: Phenotypes and Precision Medicine in Cancer, Infection, and Allergy Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26677183 Training in Systems Approaches for the Next Generation of Life Scientists and Medical Doctors Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26677180 Therapy with Plasma Purified Alpha1-antitrypsin (Prolastin®) Induces Time-dependent Changes in Plasma Levels of MMP-9 and MPO PloS One. 2015 | Pubmed ID: 25635861 Impaired TLR4 and HIF Expression in Cystic Fibrosis Bronchial Epithelial Cells Downregulates Hemeoxygenase-1 and Alters Iron Homeostasis in Vitro American Journal of Physiology. Lung Cellular and Molecular Physiology. Nov, 2014 | Pubmed ID: 25239913 Malignancy Associated MicroRNA Expression Changes in Canine Mammary Cancer of Different Malignancies ISRN Veterinary Science. 2014 | Pubmed ID: 25002976 Benefits of Whole Body Vibration Training in Patients Hospitalised for COPD Exacerbations - a Randomized Clinical Trial BMC Pulmonary Medicine. Apr, 2014 | Pubmed ID: 24725369 MicroRNAs in the Lung Advances in Experimental Medicine and Biology. 2013 | Pubmed ID: 23377971 Asthma Phenotyping, Therapy, and Prevention: What Can We Learn from Systems Biology? Pediatric Research. Apr, 2013 | Pubmed ID: 23314293 TLR9- and Src-dependent Expression of Krueppel-like Factor 4 Controls Interleukin-10 Expression in Pneumonia The European Respiratory Journal. Feb, 2013 | Pubmed ID: 22653776 Systems Biology and Bioinformatics in Aging Research: a Workshop Report Rejuvenation Research. Dec, 2012 | Pubmed ID: 22950424 Rac1 Regulates the NLRP3 Inflammasome Which Mediates IL-1beta Production in Chlamydophila Pneumoniae Infected Human Mononuclear Cells PloS One. 2012 | Pubmed ID: 22276187 Simvastatin Attenuates Ventilator-induced Lung Injury in Mice Critical Care (London, England). 2010 | Pubmed ID: 20673352 Legionella Pneumophila Induces Human Beta Defensin-3 in Pulmonary Cells Respiratory Research. Jul, 2010 | Pubmed ID: 20615218 TLR2- and Nucleotide-binding Oligomerization Domain 2-dependent Krüppel-like Factor 2 Expression Downregulates NF-kappa B-related Gene Expression Journal of Immunology (Baltimore, Md. : 1950). Jul, 2010 | Pubmed ID: 20525885 Listeria Monocytogenes-infected Human Peripheral Blood Mononuclear Cells Produce IL-1beta, Depending on Listeriolysin O and NLRP3 Journal of Immunology (Baltimore, Md. : 1950). Jan, 2010 | Pubmed ID: 20008285 Statins Control Oxidized LDL-mediated Histone Modifications and Gene Expression in Cultured Human Endothelial Cells Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2009 | Pubmed ID: 19122173 Phosphodiesterase 2 Inhibition Diminished Acute Lung Injury in Murine Pneumococcal Pneumonia Critical Care Medicine. Feb, 2009 | Pubmed ID: 19114892 Systemic Use of the Endolysin Cpl-1 Rescues Mice with Fatal Pneumococcal Pneumonia Critical Care Medicine. Feb, 2009 | Pubmed ID: 19114881 Beta-PIX and Rac1 GTPase Mediate Trafficking and Negative Regulation of NOD2 Journal of Immunology (Baltimore, Md. : 1950). Aug, 2008 | Pubmed ID: 18684957 Histone Acetylation and Flagellin Are Essential for Legionella Pneumophila-induced Cytokine Expression Journal of Immunology (Baltimore, Md. : 1950). Jul, 2008 | Pubmed ID: 18606645 NAIP and Ipaf Control Legionella Pneumophila Replication in Human Cells Journal of Immunology (Baltimore, Md. : 1950). May, 2008 | Pubmed ID: 18453601 Rho-kinase and Contractile Apparatus Proteins in Murine Airway Hyperresponsiveness Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie. Jun, 2008 | Pubmed ID: 18434112 Simvastatin Reduces Chlamydophila Pneumoniae-mediated Histone Modifications and Gene Expression in Cultured Human Endothelial Cells Circulation Research. Apr, 2008 | Pubmed ID: 18309103 Proteomic Characterization of the Whole Secretome of Legionella Pneumophila and Functional Analysis of Outer Membrane Vesicles Infection and Immunity. May, 2008 | Pubmed ID: 18250176 Cell-specific Interleukin-15 and Interleukin-15 Receptor Subunit Expression and Regulation in Pneumococcal Pneumonia--comparison to Chlamydial Lung Infection Cytokine. May, 2007 | Pubmed ID: 17611121 Role of Platelet-activating Factor in Pneumolysin-induced Acute Lung Injury Critical Care Medicine. Jul, 2007 | Pubmed ID: 17522574 The UspA1 Protein of Moraxella Catarrhalis Induces CEACAM-1-dependent Apoptosis in Alveolar Epithelial Cells The Journal of Infectious Diseases. Jun, 2007 | Pubmed ID: 17471435 Adrenomedullin Reduces Vascular Hyperpermeability and Improves Survival in Rat Septic Shock Intensive Care Medicine. Apr, 2007 | Pubmed ID: 17318497 Comparative Transcriptional Profiling of the Lung Reveals Shared and Distinct Features of Streptococcus Pneumoniae and Influenza A Virus Infection Immunology. Mar, 2007 | Pubmed ID: 17163962 IFNbeta Induction by Influenza A Virus is Mediated by RIG-I Which is Regulated by the Viral NS1 Protein Cellular Microbiology. Apr, 2007 | Pubmed ID: 17140406 Legionella Pneumophila-induced PKCalpha-, MAPK-, and NF-kappaB-dependent COX-2 Expression in Human Lung Epithelium American Journal of Physiology. Lung Cellular and Molecular Physiology. Jan, 2007 | Pubmed ID: 17012371 Legionella Pneumophila Induces IFNbeta in Lung Epithelial Cells Via IPS-1 and IRF3, Which Also Control Bacterial Replication The Journal of Biological Chemistry. Nov, 2006 | Pubmed ID: 16984921 Listeria Monocytogenes Induced Rac1-dependent Signal Transduction in Endothelial Cells Biochemical Pharmacology. Nov, 2006 | Pubmed ID: 16884694 Streptococcus Pneumoniae Induced C-Jun-N-terminal Kinase- and AP-1 -dependent IL-8 Release by Lung Epithelial BEAS-2B Cells Respiratory Research. Jul, 2006 | Pubmed ID: 16834785 Lung Epithelium As a Sentinel and Effector System in Pneumonia--molecular Mechanisms of Pathogen Recognition and Signal Transduction Respiratory Research. Jul, 2006 | Pubmed ID: 16827942 Role of Pneumolysin for the Development of Acute Lung Injury in Pneumococcal Pneumonia Critical Care Medicine. Jul, 2006 | Pubmed ID: 16715037 Perturbation of Endothelial Junction Proteins by Staphylococcus Aureus Alpha-toxin: Inhibition of Endothelial Gap Formation by Adrenomedullin Histochemistry and Cell Biology. Sep, 2006 | Pubmed ID: 16596365 Streptococcus Pneumoniae Induced P38 MAPK- and NF-kappaB-dependent COX-2 Expression in Human Lung Epithelium American Journal of Physiology. Lung Cellular and Molecular Physiology. Jun, 2006 | Pubmed ID: 16414978 Moraxella Catarrhalis Induces Inflammatory Response of Bronchial Epithelial Cells Via MAPK and NF-kappaB Activation and Histone Deacetylase Activity Reduction American Journal of Physiology. Lung Cellular and Molecular Physiology. May, 2006 | Pubmed ID: 16399788 Listeria Monocytogenes Activated P38 MAPK and Induced IL-8 Secretion in a Nucleotide-binding Oligomerization Domain 1-dependent Manner in Endothelial Cells Journal of Immunology (Baltimore, Md. : 1950). Jan, 2006 | Pubmed ID: 16365441 Mechanisms of Chlamydophila Pneumoniae-mediated GM-CSF Release in Human Bronchial Epithelial Cells American Journal of Respiratory Cell and Molecular Biology. Mar, 2006 | Pubmed ID: 16340003 Pneumococci Induced TLR- and Rac1-dependent NF-kappaB-recruitment to the IL-8 Promoter in Lung Epithelial Cells American Journal of Physiology. Lung Cellular and Molecular Physiology. Apr, 2006 | Pubmed ID: 16299055 Adhesion of Moraxella Catarrhalis to Human Bronchial Epithelium Characterized by a Novel Fluorescence-based Assay Medical Microbiology and Immunology. Jun, 2006 | Pubmed ID: 16059698 Adrenomedullin Treatment Abolishes Ileal Mucosal Hypoperfusion Induced by Staphylococcus Aureus Alpha-toxin--an Intravital Microscopic Study on an Isolated Rat Ileum Critical Care Medicine. Dec, 2005 | Pubmed ID: 16352964 Intracellular Bacteria Differentially Regulated Endothelial Cytokine Release by MAPK-dependent Histone Modification Journal of Immunology (Baltimore, Md. : 1950). Sep, 2005 | Pubmed ID: 16116170 Streptococcus Pneumoniae R6x Induced P38 MAPK and JNK-mediated Caspase-dependent Apoptosis in Human Endothelial Cells Thrombosis and Haemostasis. Aug, 2005 | Pubmed ID: 16113818 Adrenomedullin Reduces Staphylococcus Aureus Alpha-toxin-induced Rat Ileum Microcirculatory Damage Critical Care Medicine. Apr, 2005 | Pubmed ID: 15818111 Nod1-mediated Endothelial Cell Activation by Chlamydophila Pneumoniae Circulation Research. Feb, 2005 | Pubmed ID: 15653568 Neuronal Plasticity in Persistent Perennial Allergic Rhinitis Journal of Occupational and Environmental Medicine. Jan, 2005 | Pubmed ID: 15643155 Streptococcus Pneumoniae-induced P38 MAPK-dependent Phosphorylation of RelA at the Interleukin-8 Promotor The Journal of Biological Chemistry. Dec, 2004 | Pubmed ID: 15485852 Porphyromonas Gingivalis Strain-dependent Activation of Human Endothelial Cells Infection and Immunity. Oct, 2004 | Pubmed ID: 15385493 Streptococcus Pneumoniae-induced Caspase 6-dependent Apoptosis in Lung Epithelium Infection and Immunity. Sep, 2004 | Pubmed ID: 15321985 Nucleotide-binding Oligomerization Domain Proteins Are Innate Immune Receptors for Internalized Streptococcus Pneumoniae The Journal of Biological Chemistry. Aug, 2004 | Pubmed ID: 15215247 Rho Protein Inhibition Blocks Cyclooxygenase-2 Expression by Proinflammatory Mediators in Endothelial Cells Inflammation. Apr, 2003 | Pubmed ID: 12797548 Adrenomedullin Reduces Endothelial Hyperpermeability Circulation Research. Oct, 2002 | Pubmed ID: 12364390 Rho Protein Inactivation Induced Apoptosis of Cultured Human Endothelial Cells American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2002 | Pubmed ID: 12225960 Reduction of Tumor Necrosis Factor-alpha (TNF-alpha) Related Nuclear Factor-kappaB (NF-kappaB) Translocation but Not Inhibitor Kappa-B (Ikappa-B)-degradation by Rho Protein Inhibition in Human Endothelial Cells Biochemical Pharmacology. Sep, 2002 | Pubmed ID: 12213594 Legionella pneumophila der äußeren Membran - Vesikeln: Isolierung und Analyse ihrer Pro-inflammatorische Potential auf Makrophagen Anna Lena Jung1, Kerstin Hoffmann1, Christina E. Herkt1, Christine Schulz1, Wilhelm Bertrams1, Bernd Schmeck1,2,3 1Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, 2German Center for Lung Research, 3Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg JoVE 55146 Imunologia e Infecção
Legionella pneumophila der äußeren Membran - Vesikeln: Isolierung und Analyse ihrer Pro-inflammatorische Potential auf Makrophagen Anna Lena Jung1, Kerstin Hoffmann1, Christina E. Herkt1, Christine Schulz1, Wilhelm Bertrams1, Bernd Schmeck1,2,3 1Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, 2German Center for Lung Research, 3Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg JoVE 55146 Imunologia e Infecção