Bradford W. Gibson Buck Institute for Age Research Biography Publications Institution JoVE Articles Bradford W. Gibson has not added a biography. If you are Bradford W. Gibson and would like to personalize this page please email our Author Liaison for assistance. Publications The O-antigen and Core Carbohydrate of Vibrio Fischeri Lipopolysaccharide: Composition and Analysis of Their Role in Euprymna Scolopes Light Organ Colonization The Journal of Biological Chemistry. Jan, 2012 | Pubmed ID: 22247546 Proteomic Analysis of Age-dependent Changes in Protein Solubility Identifies Genes That Modulate Lifespan Aging Cell. Feb, 2012 | Pubmed ID: 22103665 Regulatory Control or Oxidative Damage? Proteomic Approaches to Interrogate the Role of Cysteine Oxidation Status in Biological Processes Molecular & Cellular Proteomics : MCP. Dec, 2011 | Pubmed ID: 22159599 Life Span Extension Via EIF4G Inhibition is Mediated by Posttranscriptional Remodeling of Stress Response Gene Expression in C. Elegans Cell Metabolism. Jul, 2011 | Pubmed ID: 21723504 Mass Spectrometric Identification of Novel Lysine Acetylation Sites in Huntingtin Molecular & Cellular Proteomics : MCP. Oct, 2011 | Pubmed ID: 21685499 N-acylethanolamine Signalling Mediates the Effect of Diet on Lifespan in Caenorhabditis Elegans Nature. May, 2011 | Pubmed ID: 21562563 Confident Identification of 3-nitrotyrosine Modifications in Mass Spectral Data Across Multiple Mass Spectrometry Platforms Journal of Proteomics. Oct, 2011 | Pubmed ID: 21514405 The Lipid A from Vibrio Fischeri Lipopolysaccharide: a Unique Structure Bearing a Phosphoglycerol Moiety The Journal of Biological Chemistry. Jun, 2011 | Pubmed ID: 21498521 Quantitative Mapping of Reversible Mitochondrial Complex I Cysteine Oxidation in a Parkinson Disease Mouse Model The Journal of Biological Chemistry. Mar, 2011 | Pubmed ID: 21196577 A Lectin Affinity Workflow Targeting Glycosite-specific, Cancer-related Carbohydrate Structures in Trypsin-digested Human Plasma Analytical Biochemistry. Jan, 2011 | Pubmed ID: 20705048 Identification of New Modulators and Protein Alterations in Non-apoptotic Programmed Cell Death Journal of Cellular Biochemistry. Dec, 2010 | Pubmed ID: 20830744 Identification, Characterization and Immunogenicity of an O-antigen Capsular Polysaccharide of Francisella Tularensis PloS One. 2010 | Pubmed ID: 20625403 ErbB2 Trafficking and Degradation Associated with K48 and K63 Polyubiquitination Cancer Research. May, 2010 | Pubmed ID: 20406983 Targeted Quantitation of Site-specific Cysteine Oxidation in Endogenous Proteins Using a Differential Alkylation and Multiple Reaction Monitoring Mass Spectrometry Approach Molecular & Cellular Proteomics : MCP. Jul, 2010 | Pubmed ID: 20233844 Utilizing the O-antigen Lipopolysaccharide Biosynthesis Pathway in Escherichia Coli to Interrogate the Substrate Specificities of Exogenous Glycosyltransferase Genes in a Combinatorial Approach Glycobiology. Jun, 2010 | Pubmed ID: 20208062 Sweetening the Pot: Adding Glycosylation to the Biomarker Discovery Equation Clinical Chemistry. Feb, 2010 | Pubmed ID: 19959616 Repeatability and Reproducibility in Proteomic Identifications by Liquid Chromatography-tandem Mass Spectrometry Journal of Proteome Research. Feb, 2010 | Pubmed ID: 19921851 Interlaboratory Study Characterizing a Yeast Performance Standard for Benchmarking LC-MS Platform Performance Molecular & Cellular Proteomics : MCP. Feb, 2010 | Pubmed ID: 19858499 Performance Metrics for Liquid Chromatography-tandem Mass Spectrometry Systems in Proteomics Analyses Molecular & Cellular Proteomics : MCP. Feb, 2010 | Pubmed ID: 19837981 The Mycobacterium Bovis Bacille Calmette-Guerin Phagosome Proteome Molecular & Cellular Proteomics : MCP. Jan, 2010 | Pubmed ID: 19815536 Preferentially Increased Nitration of Alpha-synuclein at Tyrosine-39 in a Cellular Oxidative Model of Parkinson's Disease Analytical Chemistry. Sep, 2009 | Pubmed ID: 19697948 Calpain-1 Cleaves and Activates Caspase-7 The Journal of Biological Chemistry. Sep, 2009 | Pubmed ID: 19617626 Multi-site Assessment of the Precision and Reproducibility of Multiple Reaction Monitoring-based Measurements of Proteins in Plasma Nature Biotechnology. Jul, 2009 | Pubmed ID: 19561596 IDPicker 2.0: Improved Protein Assembly with High Discrimination Peptide Identification Filtering Journal of Proteome Research. Aug, 2009 | Pubmed ID: 19522537 Systematic Mapping of Posttranslational Modifications in Human Estrogen Receptor-alpha with Emphasis on Novel Phosphorylation Sites Molecular & Cellular Proteomics : MCP. Mar, 2009 | Pubmed ID: 18984578 A Novel Serine Phosphorylation Site Detected in the N-terminal Domain of Estrogen Receptor Isolated from Human Breast Cancer Cells Journal of the American Society for Mass Spectrometry. May, 2008 | Pubmed ID: 18367407 Partial Acetylation of Lysine Residues Improves Intraprotein Cross-linking Analytical Chemistry. Feb, 2008 | Pubmed ID: 18201069 Characterization of HtrB and MsbB Mutants of the Light Organ Symbiont Vibrio Fischeri Applied and Environmental Microbiology. Feb, 2008 | Pubmed ID: 18065606 Characterization of the N-acetyl-5-neuraminic Acid-binding Site of the Extracytoplasmic Solute Receptor (SiaP) of Nontypeable Haemophilus Influenzae Strain 2019 The Journal of Biological Chemistry. Jan, 2008 | Pubmed ID: 17947229 Regulation of Sialic Acid Transport and Catabolism in Haemophilus Influenzae Molecular Microbiology. Oct, 2007 | Pubmed ID: 17880422 Identification of LpxL, a Late Acyltransferase of Francisella Tularensis Infection and Immunity. Nov, 2007 | Pubmed ID: 17724076 Proteomic Analysis of Plasma Membrane and Secretory Vesicles from Human Neutrophils Proteome Science. 2007 | Pubmed ID: 17692124 Proposed Second Class of Haemophilus Ducreyi Strains Show Altered Protein and Lipooligosaccharide Profiles Proteomics. Sep, 2007 | Pubmed ID: 17676659 Small-scale Immunopurification of Cytochrome C Oxidase for a High-throughput Multiplexing Analysis of Enzyme Activity and Amount Biotechnology and Applied Biochemistry. Dec, 2007 | Pubmed ID: 17508937 Quantification of Cysteine Oxidation in Human Estrogen Receptor by Mass Spectrometry Analytical Chemistry. Apr, 2007 | Pubmed ID: 17373775 Characterization of Lipid A Acylation Patterns in Francisella Tularensis, Francisella Novicida, and Francisella Philomiragia Using Multiple-stage Mass Spectrometry and Matrix-assisted Laser Desorption/ionization on an Intermediate Vacuum Source Linear Ion Trap Analytical Chemistry. Feb, 2007 | Pubmed ID: 17263332 Identification of Genes Involved in the Expression of Atypical Lipooligosaccharide Structures from a Second Class of Haemophilus Ducreyi Infection and Immunity. Jan, 2007 | Pubmed ID: 17030566 Novel Pathways Associated with Quinone-induced Stress in Breast Cancer Cells Drug Metabolism Reviews. 2006 | Pubmed ID: 17145690 Role of LgtC in Resistance of Nontypeable Haemophilus Influenzae Strain R2866 to Human Serum Infection and Immunity. Nov, 2006 | Pubmed ID: 16966407 DAF-12-dependent Rescue of Dauer Formation in Caenorhabditis Elegans by (25S)-cholestenoic Acid Aging Cell. Aug, 2006 | Pubmed ID: 16913876 Huntingtin Phosphorylation Sites Mapped by Mass Spectrometry. Modulation of Cleavage and Toxicity The Journal of Biological Chemistry. Aug, 2006 | Pubmed ID: 16782707 Stable Isotope Metabolic Labeling of Neisseria Meningitidis Lipooligosaccharide Journal of Endotoxin Research. 2006 | Pubmed ID: 16690012 Proteomic Analysis of Succinate Dehydrogenase and Ubiquinol-cytochrome C Reductase (Complex II and III) Isolated by Immunoprecipitation from Bovine and Mouse Heart Mitochondria Biochimica Et Biophysica Acta. Feb, 2006 | Pubmed ID: 16120479 Identification of a Novel Sialic Acid Transporter in Haemophilus Ducreyi Infection and Immunity. Oct, 2005 | Pubmed ID: 16177350 Novel Sialic Acid Transporter of Haemophilus Influenzae Infection and Immunity. Sep, 2005 | Pubmed ID: 16113244 Biochemical and Functional Characterization of Membrane Blebs Purified from Neisseria Meningitidis Serogroup B The Journal of Biological Chemistry. Nov, 2005 | Pubmed ID: 16103114 Mass Spectrometric Identification of a Novel Phosphorylation Site in Subunit NDUFA10 of Bovine Mitochondrial Complex I FEBS Letters. Apr, 2005 | Pubmed ID: 15848193 Characterization of a Cluster of Three Glycosyltransferase Enzymes Essential for Moraxella Catarrhalis Lipooligosaccharide Assembly Journal of Bacteriology. May, 2005 | Pubmed ID: 15838019 The Human Mitochondrial Proteome: Oxidative Stress, Protein Modifications and Oxidative Phosphorylation The International Journal of Biochemistry & Cell Biology. May, 2005 | Pubmed ID: 15743667 Rapid Purification and Mass Spectrometric Characterization of Mitochondrial NADH Dehydrogenase (Complex I) from Rodent Brain and a Dopaminergic Neuronal Cell Line Molecular & Cellular Proteomics : MCP. Jan, 2005 | Pubmed ID: 15591592 Lipophilic Regulator of a Developmental Switch in Caenorhabditis Elegans Aging Cell. Dec, 2004 | Pubmed ID: 15569358 Novel Modification of Lipid A of Francisella Tularensis Infection and Immunity. Sep, 2004 | Pubmed ID: 15322031 Matrix-assisted Laser Desorption/ionization-time of Flight-mass Spectrometry of Lipopolysaccharide Species Separated by Slab-polyacrylamide Gel Electrophoresis: High-resolution Separation and Molecular Weight Determination of Lipooligosaccharides from Vibrio Fischeri Strain HMK Electrophoresis. Jul, 2004 | Pubmed ID: 15273999 Expanded Coverage of the Human Heart Mitochondrial Proteome Using Multidimensional Liquid Chromatography Coupled with Tandem Mass Spectrometry Journal of Proteome Research. May-Jun, 2004 | Pubmed ID: 15253431 Exploiting Proteomics in the Discovery of Drugs That Target Mitochondrial Oxidative Damage Science of Aging Knowledge Environment : SAGE KE. Mar, 2004 | Pubmed ID: 15028863 Proteomic and Immunochemical Characterization of a Role for Stathmin in Adult Neurogenesis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2004 | Pubmed ID: 14769823 The Streptococcus Gordonii Platelet Binding Protein GspB Undergoes Glycosylation Independently of Export Journal of Bacteriology. Feb, 2004 | Pubmed ID: 14729688 Molecular Components of a Cell Death Pathway Activated by Endoplasmic Reticulum Stress The Journal of Biological Chemistry. Jan, 2004 | Pubmed ID: 14561754 Proteome of Haemophilus Ducreyi by 2-D SDS-PAGE and Mass Spectrometry: Strain Variation, Virulence, and Carbohydrate Expression Journal of Proteome Research. Sep-Oct, 2003 | Pubmed ID: 14582649 Identification of a 3-deoxy-D-manno-octulosonic Acid Biosynthetic Operon in Moraxella Catarrhalis and Analysis of a KdsA-deficient Isogenic Mutant Infection and Immunity. Nov, 2003 | Pubmed ID: 14573664 Phosphospecific Proteolysis for Mapping Sites of Protein Phosphorylation Nature Biotechnology. Sep, 2003 | Pubmed ID: 12923550 MS2Assign, Automated Assignment and Nomenclature of Tandem Mass Spectra of Chemically Crosslinked Peptides Journal of the American Society for Mass Spectrometry. Aug, 2003 | Pubmed ID: 12892908 Primary Sequence Characterization of Catestatin Intermediates and Peptides Defines Proteolytic Cleavage Sites Utilized for Converting Chromogranin a into Active Catestatin Secreted from Neuroendocrine Chromaffin Cells Biochemistry. Jun, 2003 | Pubmed ID: 12795588 Metabolic Incorporation of Unnatural Sialic Acids into Haemophilus Ducreyi Lipooligosaccharides Proceedings of the National Academy of Sciences of the United States of America. Mar, 2003 | Pubmed ID: 12615992 Characterization of the Human Heart Mitochondrial Proteome Nature Biotechnology. Mar, 2003 | Pubmed ID: 12592411 The MsbB Mutant of Neisseria Meningitidis Strain NMB Has a Defect in Lipooligosaccharide Assembly and Transport to the Outer Membrane Infection and Immunity. Feb, 2003 | Pubmed ID: 12540541 An Alternative Strategy to Determine the Mitochondrial Proteome Using Sucrose Gradient Fractionation and 1D PAGE on Highly Purified Human Heart Mitochondria Journal of Proteome Research. Sep-Oct, 2002 | Pubmed ID: 12645917 Identification and Characterization of the N-acetylglucosamine Glycosyltransferase Gene of Haemophilus Ducreyi Infection and Immunity. Oct, 2002 | Pubmed ID: 12228324 Characterization of Lipooligosaccharides from Haemophilus Ducreyi Containing Polylactosamine Repeats Journal of the American Society for Mass Spectrometry. Jun, 2002 | Pubmed ID: 12056572 The LbgAB Gene Cluster of Haemophilus Ducreyi Encodes a Beta-1,4-galactosyltransferase and an Alpha-1,6-DD-heptosyltransferase Involved in Lipooligosaccharide Biosynthesis Infection and Immunity. Jun, 2002 | Pubmed ID: 12010972 Haemophilus Influenzae Type B Strain A2 Has Multiple Sialyltransferases Involved in Lipooligosaccharide Sialylation The Journal of Biological Chemistry. Apr, 2002 | Pubmed ID: 11842084 Intracellular Survival of Neisseria Gonorrhoeae in Male Urethral Epithelial Cells: Importance of a Hexaacyl Lipid A Infection and Immunity. Feb, 2002 | Pubmed ID: 11796626 A Lectin HPLC Method to Enrich Selectively-glycosylated Peptides from Complex Biological Samples Eric Johansen1, Birgit Schilling2, Michael Lerch1, Richard K. Niles1, Haichuan Liu1, Bensheng Li2, Simon Allen1, Steven C. Hall1, H. Ewa Witkowska1, Fred E. Regnier3, Bradford W. Gibson2, Susan J. Fisher1, Penelope M. Drake1 1Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco - UCSF, 2Buck Institute for Age Research, 3Department of Chemistry, Purdue University JoVE 1398 Biologia
A Lectin HPLC Method to Enrich Selectively-glycosylated Peptides from Complex Biological Samples Eric Johansen1, Birgit Schilling2, Michael Lerch1, Richard K. Niles1, Haichuan Liu1, Bensheng Li2, Simon Allen1, Steven C. Hall1, H. Ewa Witkowska1, Fred E. Regnier3, Bradford W. Gibson2, Susan J. Fisher1, Penelope M. Drake1 1Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco - UCSF, 2Buck Institute for Age Research, 3Department of Chemistry, Purdue University JoVE 1398 Biologia