Brant E. Isakson Department of Molecular Physiology and Biophysics University of Virginia School of Medicine Biography Publications Institution JoVE Articles Brant E. Isakson has not added a biography. If you are Brant E. Isakson and would like to personalize this page please email our Author Liaison for assistance. Publications ZP1609/danegaptide and Mitochondrial Connexin Hemichannels: a Harbinger for Peptide Drug Design British Journal of Pharmacology. Aug, 2017 | Pubmed ID: 28567717 The Evolving Role of Diverse Gaseous Transmitters Mediating Heterocellular Communication Within the Vasculature Antioxidants & Redox Signaling. Jun, 2017 | Pubmed ID: 28288516 Smooth Muscle Cell-specific Deletion of Col15a1 Unexpectedly Leads to Impaired Development of Advanced Atherosclerotic Lesions American Journal of Physiology. Heart and Circulatory Physiology. May, 2017 | Pubmed ID: 28283548 Signaling Pathways Linked to Serotonin-Induced Superoxide Anion Production: A Physiological Role for Mitochondria in Pulmonary Arteries Frontiers in Physiology. 2017 | Pubmed ID: 28232807 Pannexin Channel and Connexin Hemichannel Expression in Vascular Function and Inflammation BMC Cell Biology. Jan, 2017 | Pubmed ID: 28124621 Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia Antioxidants & Redox Signaling. May, 2017 | Pubmed ID: 27889956 Modulating Vascular Hemodynamics With an Alpha Globin Mimetic Peptide (HbαX) Hypertension (Dallas, Tex. : 1979). Dec, 2016 | Pubmed ID: 27802421 AXL-Mediated Productive Infection of Human Endothelial Cells by Zika Virus Circulation Research. Nov, 2016 | Pubmed ID: 27650556 Cardiovascular Magnetic Resonance Detects the Progression of Impaired Myocardial Perfusion Reserve and Increased Left-ventricular Mass in Mice Fed a High-fat Diet Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance. Sep, 2016 | Pubmed ID: 27609091 Central Role of P2Y6 UDP Receptor in Arteriolar Myogenic Tone Arteriosclerosis, Thrombosis, and Vascular Biology. Aug, 2016 | Pubmed ID: 27255725 Small Interfering RNA-Mediated Connexin Gene Knockdown in Vascular Endothelial and Smooth Muscle Cells Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 27207287 Two Functionally Distinct Pools of ENOS in Endothelium Are Facilitated by Myoendothelial Junction Lipid Composition Biochimica Et Biophysica Acta. Jul, 2016 | Pubmed ID: 27106139 CCR7 and IRF4-dependent Dendritic Cells Regulate Lymphatic Collecting Vessel Permeability The Journal of Clinical Investigation. Apr, 2016 | Pubmed ID: 26999610 Pannexin 1 is Required for Full Activation of Insulin-stimulated Glucose Uptake in Adipocytes Molecular Metabolism. Sep, 2015 | Pubmed ID: 26413467 Endothelial Nitric Oxide Synthase in the Microcirculation Cellular and Molecular Life Sciences : CMLS. Dec, 2015 | Pubmed ID: 26390975 The Connexin 43/ZO-1 Complex Regulates Cerebral Endothelial F-actin Architecture and Migration American Journal of Physiology. Cell Physiology. Nov, 2015 | Pubmed ID: 26289751 Pannexin 1 Channels Regulate Leukocyte Emigration Through the Venous Endothelium During Acute Inflammation Nature Communications. Aug, 2015 | Pubmed ID: 26242575 Emerging Concepts Regarding Pannexin 1 in the Vasculature Biochemical Society Transactions. Jun, 2015 | Pubmed ID: 26009197 A Molecular Signature in the Pannexin1 Intracellular Loop Confers Channel Activation by the α1 Adrenoreceptor in Smooth Muscle Cells Science Signaling. Feb, 2015 | Pubmed ID: 25690012 Hemoglobin α/eNOS Coupling at Myoendothelial Junctions is Required for Nitric Oxide Scavenging During Vasoconstriction Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2014 | Pubmed ID: 25278292 The Myoendothelial Junction: Connections That Deliver the Message Physiology (Bethesda, Md.). Jul, 2014 | Pubmed ID: 24985328 Hemoglobin α in the Blood Vessel Wall Free Radical Biology & Medicine. Aug, 2014 | Pubmed ID: 24832680 Regulation of Cellular Communication by Signaling Microdomains in the Blood Vessel Wall Pharmacological Reviews. 2014 | Pubmed ID: 24671377 Connexins, Pannexins and Innexins: Protein Cousins with Overlapping Functions FEBS Letters. Apr, 2014 | Pubmed ID: 24613922 Pannexin-1 As a Potentiator of Ligand-gated Receptor Signaling Channels (Austin, Tex.). 2014 | Pubmed ID: 24576994 Differentiating Connexin Hemichannels and Pannexin Channels in Cellular ATP Release FEBS Letters. Apr, 2014 | Pubmed ID: 24548565 Secreting Von Willebrand Factor in a Gα-SNAP Blood. Jan, 2014 | Pubmed ID: 24434997 Diverse Post-translational Modifications of the Pannexin Family of Channel-forming Proteins Channels (Austin, Tex.). 2014 | Pubmed ID: 24418849 Vascular Biomechanical Properties in Mice with Smooth Muscle Specific Deletion of Ndst1 Molecular and Cellular Biochemistry. Jan, 2014 | Pubmed ID: 24101444 Loss of Collectrin, an Angiotensin-converting Enzyme 2 Homolog, Uncouples Endothelial Nitric Oxide Synthase and Causes Hypertension and Vascular Dysfunction Circulation. Oct, 2013 | Pubmed ID: 24048198 Endothelial Cell Expression of Haemoglobin α Regulates Nitric Oxide Signalling Nature. Nov, 2012 | Pubmed ID: 23123858 Hypoxic Pulmonary Vasoconstriction Requires Connexin 40-mediated Endothelial Signal Conduction The Journal of Clinical Investigation. Nov, 2012 | Pubmed ID: 23093775 S-nitrosylation Inhibits Pannexin 1 Channel Function The Journal of Biological Chemistry. Nov, 2012 | Pubmed ID: 23033481 Pannexin 1 in the Regulation of Vascular Tone Trends in Cardiovascular Medicine. Apr, 2012 | Pubmed ID: 22841835 Posttranslational Modifications in Connexins and Pannexins The Journal of Membrane Biology. Jun, 2012 | Pubmed ID: 22739962 Expression of Pannexin Isoforms in the Systemic Murine Arterial Network Journal of Vascular Research. 2012 | Pubmed ID: 22739252 Mechanisms of ATP Release and Signalling in the Blood Vessel Wall Cardiovascular Research. Aug, 2012 | Pubmed ID: 22678409 MAPK Phosphorylation of Connexin 43 Promotes Binding of Cyclin E and Smooth Muscle Cell Proliferation Circulation Research. Jul, 2012 | Pubmed ID: 22652908 Smooth Muscle Specific Deletion of Ndst1 Leads to Decreased Vessel Luminal Area and No Change in Blood Pressure in Conscious Mice Journal of Cardiovascular Translational Research. Jun, 2012 | Pubmed ID: 22555965 Loss of Compliance in Small Arteries, but Not in Conduit Arteries, After 6 Weeks Exposure to High Fat Diet Journal of Cardiovascular Translational Research. Jun, 2012 | Pubmed ID: 22467359 A Novel MRNA Binding Protein Complex Promotes Localized Plasminogen Activator Inhibitor-1 Accumulation at the Myoendothelial Junction Arteriosclerosis, Thrombosis, and Vascular Biology. May, 2012 | Pubmed ID: 22383705 Characterization of the Thoracodorsal Artery: Morphology and Reactivity Microcirculation (New York, N.Y. : 1994). May, 2012 | Pubmed ID: 22335567 Spontaneous Lung Dysfunction and Fibrosis in Mice Lacking Connexin 40 and Endothelial Cell Connexin 43 The American Journal of Pathology. Jun, 2011 | Pubmed ID: 21641379 Pannexin1 Regula α1-adrenérgicos Mediada Por Vasoconstricción Circulation Research. Jun, 2011 | Pubmed ID: 21546608 Un Nuevo Método Para La Visualización En Vivo De Vaso Remodelado Con Un Tinte De Infrarrojo Cercano Microcirculation (New York, N.Y. : 1994). Apr, 2011 | Pubmed ID: 21418375 Compartmentalized Connexin 43 S-nitrosylation/denitrosylation Regulates Heterocellular Communication in the Vessel Wall Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2011 | Pubmed ID: 21071693 Pannexin 1 Canales Mediar "find-me 'de Lanzamiento De La Señal Y La Permeabilidad De La Membrana Durante La Apoptosis Nature. Oct, 2010 | Pubmed ID: 20944749 Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids Via Nrf2 Circulation Research. Sep, 2010 | Pubmed ID: 20651288 Enhanced Connexin 43 Expression Delays Intra-mitotic Duration and Cell Cycle Traverse Independently of Gap Junction Channel Function Journal of Cellular Biochemistry. Jun, 2010 | Pubmed ID: 20512937 Plasminogen Activator Inhibitor-1 Regulates Myoendothelial Junction Formation Circulation Research. Apr, 2010 | Pubmed ID: 20133900 Site-specific Connexin Phosphorylation is Associated with Reduced Heterocellular Communication Between Smooth Muscle and Endothelium Journal of Vascular Research. 2010 | Pubmed ID: 20016202 The Importance of Serine 161 in the Sodium Channel Beta3 Subunit for Modulation of Na(V)1.2 Gating Pflugers Archiv : European Journal of Physiology. Sep, 2010 | Pubmed ID: 19806359 Oxidized Phospholipid Species Promote in Vivo Differential Cx43 Phosphorylation and Vascular Smooth Muscle Cell Proliferation The American Journal of Pathology. Aug, 2009 | Pubmed ID: 19608875 The Myoendothelial Junction: Breaking Through the Matrix? Microcirculation (New York, N.Y. : 1994). May, 2009 | Pubmed ID: 19330678 Connexins in Vascular Physiology and Pathology Antioxidants & Redox Signaling. Feb, 2009 | Pubmed ID: 18834327 Localized Expression of an Ins(1,4,5)P3 Receptor at the Myoendothelial Junction Selectively Regulates Heterocellular Ca2+ Communication Journal of Cell Science. Nov, 2008 | Pubmed ID: 18946029 Incidence of Protein on Actin Bridges Between Endothelium and Smooth Muscle in Arterioles Demonstrates Heterogeneous Connexin Expression and Phosphorylation American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2008 | Pubmed ID: 18408134 Ca2+ and Inositol 1,4,5-trisphosphate-mediated Signaling Across the Myoendothelial Junction Circulation Research. Feb, 2007 | Pubmed ID: 17218602 Vascular Gap Junctions in Hypertension Hypertension (Dallas, Tex. : 1979). Nov, 2006 | Pubmed ID: 17015783 Laminin-332 Alters Connexin Profile, Dye Coupling and Intercellular Ca2+ Waves in Ciliated Tracheal Epithelial Cells Respiratory Research. Aug, 2006 | Pubmed ID: 16884540 Oxidized Phospholipids Alter Vascular Connexin Expression, Phosphorylation, and Heterocellular Communication Arteriosclerosis, Thrombosis, and Vascular Biology. Oct, 2006 | Pubmed ID: 16857951 Connexin40 and Connexin43 in Mouse Aortic Endothelium: Evidence for Coordinated Regulation American Journal of Physiology. Heart and Circulatory Physiology. Mar, 2006 | Pubmed ID: 16284228 Extracellular Matrix-driven Alveolar Epithelial Cell Differentiation in Vitro Experimental Lung Research. Jun, 2005 | Pubmed ID: 16047415 Heterocellular Contact at the Myoendothelial Junction Influences Gap Junction Organization Circulation Research. Jul, 2005 | Pubmed ID: 15961721 Connexins: Gaps in Our Knowledge of Vascular Function Physiology (Bethesda, Md.). Oct, 2004 | Pubmed ID: 15381756 Cell-cell Communication in Heterocellular Cultures of Alveolar Epithelial Cells American Journal of Respiratory Cell and Molecular Biology. Nov, 2003 | Pubmed ID: 12748060 Heterocellular Cultures of Pulmonary Alveolar Epithelial Cells Grown on Laminin-5 Supplemented Matrix In Vitro Cellular & Developmental Biology. Animal. Sep, 2002 | Pubmed ID: 12605538 Culturing Alveolar Type I, Alveolar Type II, and Mixed Cell Populations by Altering the Extracellular Matrix Promotes Changes in Intercellular Signaling Mechanisms Chest. Mar, 2002 | Pubmed ID: 11893676 Un modelo de cultivo celular de las arterias de resistencia Lauren A. Biwer1,2, Christophe Lechauve3, Sheri Vanhoose4, Mitchell J. Weiss3, Brant E. Isakson1,2 1Department of Molecular Physiology and Biophysics, University of Virginia School of Medicine, 2Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, 3Department of Hematology, St. Jude Children's Research Hospital, 4Research Histology Core, University of Virginia School of Medicine JoVE 55992 Medicina
Un modelo de cultivo celular de las arterias de resistencia Lauren A. Biwer1,2, Christophe Lechauve3, Sheri Vanhoose4, Mitchell J. Weiss3, Brant E. Isakson1,2 1Department of Molecular Physiology and Biophysics, University of Virginia School of Medicine, 2Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, 3Department of Hematology, St. Jude Children's Research Hospital, 4Research Histology Core, University of Virginia School of Medicine JoVE 55992 Medicina